A5084844516- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Radiopharmaceutical Chemistry and Applications
- Crystallography and molecular interactions
- Organometallic Complex Synthesis and Catalysis
- Medical Imaging Techniques and Applications
- Lanthanide and Transition Metal Complexes
- N-Heterocyclic Carbenes in Organic and Inorganic Chemistry
- Synthetic Organic Chemistry Methods
- Ferrocene Chemistry and Applications
- Peptidase Inhibition and Analysis
- Medical Imaging and Pathology Studies
- Catalytic Cross-Coupling Reactions
- International Science and Diplomacy
- Metal complexes synthesis and properties
- Radioactive element chemistry and processing
- Chemical Synthesis and Analysis
- Fluorine in Organic Chemistry
- Synthesis and characterization of novel inorganic/organometallic compounds
- Asymmetric Hydrogenation and Catalysis
- Carbon dioxide utilization in catalysis
- Magnetism in coordination complexes
- Molecular Sensors and Ion Detection
- Synthesis and Biological Evaluation
- Monoclonal and Polyclonal Antibodies Research
University of Zurich
2016-2025
Laboratoire Chimie Electrochimie Moléculaires et Chimie Analytique
2024
Université de Bretagne Occidentale
2024
Centre National de la Recherche Scientifique
2024
Freie Universität Berlin
2003-2007
Universidade de Vigo
2005
Too hot to handle: Unprecedented affinity and specificity for 99TcO4− in aqueous solution was shown with the p-xylyl azacryptand hexaprotonated form (see scheme). A crystal structure of complex reveals how anion fits within cavity cage, formation multiple H-bond interactions protonated amino groups stabilize adduct.
The fluorescent cage senses pertechnetate in water at μM concentration, opening perspectives to detect the pollutant without radioanalytical instrumentation.
Light-induced bioconjugation and radiolabeling of the cancer-specific monoclonal antibody onartuzumab was accomplished using tricarbonyl chemistry radiotheranostic matched pair nuclides 99m Tc 188 Re.
Bis-arene complexes of technetium represent a fundamental class organometallic compounds. Due to complex synthetic routes, no detailed insights into their properties have been reported so far. Reacting [99TcO4]- with arenes in the exclusive presence AlCl3 gives highly stable [99Tc(arene)2]+ good yields. These extraordinarily high stabilities, where oxidation is found occur at potentials higher than +1.3 V and reduction below -2 vs. Fc/Fc+. The 99mTc analogues are similarly synthesised by...
Cationic dioxorhenium and dioxotechnetium complexes of the composition [MO(2)(L(1))(4)](+) (L(1) = 1,3-diisopropyl-4,5-dimethylimidazol-2-ylidene) have been prepared from various starting materials studied spectroscopically by X-ray crystallography. The metal-carbon distances range 2.216(4) to 2.232(4) A indicating mainly sigma-bonding.
The first 99 Tc corroles have been synthesized and fully characterized. A single-crystal X-ray structure of a TcO triarylcorrole revealed nearly identical geometry parameters as the corresponding ReO structure. significant spectral shift between Soret maxima (410-413 nm) (438-441 was observed and, based on two-component spin-orbit ZORA TDDFT calculations, ascribed to relativistic effects in Re case. syntheses reported herein potentially pave way toward 99m Tc-porphyrinoid-based radiopharmaceuticals.
Sandwich complexes are important building blocks in medicinal inorganic chemistry for group 6 and 8 elements but almost unknown the manganese triad. We present syntheses full characterization of mixed-arene 99Tc sandwich [99Tc(η6-hmbz)(η6-C6H5-NH3)](PF6)2 [99Tc(η6-hmbz)(η6-C6H5-Br)](PF6). Both comprise functionalities conjugation to targeting molecules or being included as substructures pharmaceutically active lead compounds. Since η6-benzene ligands too stably bound be replaced with...
The labeling of (bio)molecules with metallic radionuclides such as 99m Tc demands conjugated, multidentate chelators. However, this is not always necessary since phenyl rings can directly serve integrated, organometallic ligands. Bis-arene sandwich complexes are generally prepared by the Fischer-Hafner reaction. In extension this, we show that [99m Tc(η6 -C6 R6 )2 ]+ -type accessible from water and TcO4 ]- , even using arenes incompatible conditions. To unambiguously confirm nature these...
A new concept for the synthesis of dual-functionalized technetium (Tc) compounds is presented, on basis reactivity fac-{Tc(VII)O(3)}(+) complexes. The combines "classical" bifunctional chelator (BFC) approach with ligand centered labeling strategy fac-{TcO(3)}(+) complexes alkenes ((3 + 2)-cycloaddition approach). To evidence this concept, fac-{(99)TcO(3)}(+) model containing functionalized 1,4,7-triazacyclononane (tacn) derivatives N-benzyl-2-(1,4,7-triazonan-1-yl)acetamide (tacn-ba) and...
The contraction of coordinated aromatic hydrocarbons is a rare reactivity pattern in organometallic chemistry. We describe the conversion bromobenzene to ReI center into cyclopentadienyl aldehyde. Under mildly alkaline conditions, expected phenol complex formed with Re and 99Tc but under strong basic conditions; ring occurs close quantitative yields for only. A mechanism this unprecedented reaction proposed based on 1H 2H NMR spectra density functional theory calculations.
The synthesis of mono- and difunctionalized [Re(η6-C6H5R)(η6-C6H6–nRn)]+ (n = 0, 1; R COOH, Br) complexes starting from [Re(η6-benzene)2]+ is described. lithiation with n-BuLi leads preferentially to the neutral, alkylated product [Re(η6-C6H6)(η5-C6H6-Bu)] but not expected deprotonation arene ring. Deprotonation/lithiation LDA gave dilithiated products in situ. Their reactions 1,1,2,2-tetra-bromoethane (TBE) or CO2, respectively, [Re(η6-C6H5Br)(η6-C6H6)]+, [Re(η6-C6H5Br)2]+,...
The fac – mer isomerisation in [MX 3 (CO) ] 2− (M = Re, 99 Tc) is induced by a PNP pincer-type ligand the presence of halide scavenger. adaptation to aqueous and saline chemistry 99m Tc yields -[ Tc(PNP)(CO) + .
The highly reactive mixed anhydrides [TcO3(OCOPh)] and [TcO3(OBF3)]- were synthesized by treatment of [TcO4]- with strong Lewis acids benzoyl chloride BF3·OEt2. These anhydrides, prepared in situ, used as precursors for the synthesis complexes containing [TcO3]+ core. Subsequent reactions bi- or tridentate ligands resulted new comprised As examples bidentate ligands, classical [TcO3Cl(bipy)] (1) (bipy = 2,2'-bipyridine) [TcO3Cl(phen)] (2) (phen 1,10-phenanthroline) have been this strategy...
Abstract The 2‐(4′‐aminophenyl)‐6‐methylbenzothiazole that is known to display affinity and specificity toward the amyloid plaques of Alzheimer's disease (AD) has been joined tricarbonyl [M(CO) 3 NNO] chelate (M = Re, 99 Tc, 99m Tc) through a five‐carbon linker chain generate neutral complex 1 (namely, Re‐1 for M Re; Tc‐1 Tc; with aim developing single‐photon emission computed tomography (SPECT) radiodiagnostic agent AD. was characterized by spectroscopic methods X‐ray crystallography,...
[NEt4]2[Tc(CO)3Cl3] reacts with thiosemicarbazones derived from 2,2'-dipyridyl ketone (HL3) and 4-acetylpyridine (HL4) to form stable technetium(I) complexes of the compositions [Tc(CO)3Cl(HL3-Npy,Npy)] [Tc2(CO)6Cl2(micro-HL4-Npy,S)]. Whereas exclusively pyridine nitrogen atoms are involved in coordination monomeric complex, binuclear compound represents first technetium complex a coordinated thiosemicarbazone functionality.
Abstract Reactions of the oxorhenium(V) complexes [ReOX 3 (PPh ) 2 ] (X = Cl, Br) with N‐heterocyclic carbene (NHC) 1,3,4‐triphenyl‐1,2,4‐triazol‐5‐ylidene (L Ph under mild conditions and in presence MeOH or water give (Y)(PPh )(L )] Br; Y OMe, OH). Attempted reactions precursor 5‐methoxy‐1,3,4‐triphenyl‐4,5‐dihydro‐ 1H ‐1,2,4‐triazole ( 1 [ReOCl [NBu 4 ][ReOCl boiling xylene resulted protonation intermediately formed decomposition products such as [HL (OPPh )], (OH ][ReO were isolated. The...
[NBu4][TcOCl4] reacts with ethylene glycol and 1,4,7-triazacyclononane (tacn) in MeOH under the formation of deep-blue oxotechnetium(V) cation [TcO(OC2H4O)(tacn)]+, which can readily be oxidized by air to give stable technetium(VII) compound [TcO3(tacn)]+. The reaction aqueous HCl results reduction cationic technetium(III) complex [TcCl2(OH2)(tacn)]Cl. products were isolated crystalline form studied spectroscopically X-ray diffraction.
Reported herein is a new concept for the labelling of biomolecules with small [(99m)TcO(3)](+) complexes through [3+2] cycloaddition alkenes radiopharmaceutical applications. We developed convenient reactions synthesis small, water stable fac-[TcO(3)(tacn-R)](+) ((99)Tc and (99m)Tc, tacn = 1,4,7-triazacyclononane, R H, -CH(2)-C(6)H(5), -CH(2)-C(6)H(4)COOH). With alkenes, these high valent undergo formation corresponding Tc(V)-glycolato complexes. The (99m)Tc(V) (99m)Tc(VII) are at 37 degrees...
A novel azido derivative of the di-(2-picolyl)amide (Dpam) ligand, namely 3-azido-N,N-bis-pyridin-2-ylmethyl-propionamide (3), was prepared from 3-bromo-N,N-bis(pyridin-2-ylmethyl)propanamide (2) with an excess sodium azide in DMSO. 3 then reacted, by CuI-catalyzed [3 + 2] cycloaddition (often referred to as ‘Click Chemistry’), previously reported alkyne-containing peptide nucleic acid (PNA) monomer Fmoc-1-OtBu give Dpam-containing PNA (Fmoc-4-OtBu) 44% yield. It also demonstrated that could...
99TcVO2–NHC complexes containing monodentate and bidentate N-heterocyclic carbenes (NHCs) have been prepared by the reactions of [TcO(glyc)2]− (glyc = ethyleneglycolato) with 1,3-dimethylimidazoline-2-ylidene (L1), 1,1′-methylene-3,3′-dimethyl-4,4′-diimidazoline-2,2′-diylidene (L2), 1,1′-methylene-3,3′-diethyl-4,4′-diimidazoline-2,2′-diylidene (L3) in THF. The resulting were fully characterized their stabilities investigated. While NHCs only are hydrolytically unstable, water-stable over a...