A5086012384- Venous Thromboembolism Diagnosis and Management
- Blood Pressure and Hypertension Studies
- Renin-Angiotensin System Studies
- Renal and Vascular Pathologies
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiovascular Health and Disease Prevention
- Liver Disease Diagnosis and Treatment
- Atherosclerosis and Cardiovascular Diseases
- Cardiovascular Function and Risk Factors
- Cardiovascular Disease and Adiposity
- Ultrasound in Clinical Applications
- Systemic Sclerosis and Related Diseases
- Cardiovascular Effects of Exercise
- Blood properties and coagulation
- Peripheral Artery Disease Management
- Cardiac Fibrosis and Remodeling
- Hormonal Regulation and Hypertension
- Pulmonary Hypertension Research and Treatments
- Acute Myocardial Infarction Research
- Health and Lifestyle Studies
- Systemic Lupus Erythematosus Research
- Obesity, Physical Activity, Diet
- Central Venous Catheters and Hemodialysis
- Cardiac Imaging and Diagnostics
- Sodium Intake and Health
University of Florence
2015-2024
Azienda Ospedaliero-Universitaria Careggi
2011-2024
Terra
2020
University of Siena
1999-2020
Ospedale di Livorno
2020
Cambridge University Press
2020
Infinera (United States)
2020
Sapienza University of Rome
2012-2019
University of Washington
2019
Society of Thoracic Surgeons
2017
Abstract —In 76 patients with heart failure (HF) (New York Heart Association [NYHA] classes I through IV) and in 15 control subjects, cardiac angiotensin II (Ang II) generation its relationship left ventricular function were investigated by measuring aorta–coronary sinus concentration gradients of endogenous angiotensins a part studying 125 I-labeled Ang kinetics. Gene expression cellular localization the renin-angiotensin system components, density AT 1 2 on membranes isolated myocytes,...
Physiological hypertrophy represents the adaptive changes of heart required for supporting increased hemodynamic load in regularly trained healthy subjects. Mechanisms responsible athlete’s still remain unknown. In 15 competitive soccer players and men not engaged sporting activities (sedentary control subjects) equivalent age, we investigated relationship among cardiac growth factor formation, sympathetic activity, left ventricular morphology function. Cardiac formation insulin-like...
Objective Since Behçet's syndrome (BS) is the prototype of inflammation‐induced thrombosis, immunosuppressants are recommended in place anticoagulants. We undertook this study to assess clinical efficacy and corticosteroid‐sparing effect adalimumab (ADA)–based treatment versus disease‐modifying antirheumatic drug (DMARD) therapy a large retrospective cohort patients with BS‐related venous thrombosis. Methods retrospectively collected data on 70 BS treated DMARDs or ADA‐based regimens (ADA...
Abstract —The aim of the present study was to investigate whether and which cardiac growth factors are involved in human hypertrophy, factor synthesis is influenced by overload type and/or adequacy relationships between formation ventricular function. Cardiac assessed measuring aorta-coronary sinus concentration gradient patients with isolated aortic stenosis (n=26) or regurgitation (n=15) controls (n=12). Gene expression cellular localization investigated biopsies using reverse...
Abstract —Only scarce information is available on the activity and modifications of cardiac endothelin (ET)–1 system in heart failure due to ischemic (ICM) or idiopathic dilated (DCM) cardiomyopathy. The ET-1 was investigated by measuring big formation quantifying mRNA for prepro–ET-1 (ppET-1), ET-converting enzyme-1, ET A B receptors both myocardium isolated myocytes using Northern blot, reverse transcription–polymerase chain reaction, situ hybridization 22 patients with DCM 20 ICM who...
Mechanical factors play a key role in activation of cardiac growth factor response hemodynamic overload, and both cooperate myocardial remodeling. The present study was performed to investigate whether different is activated the right left ventricles aortocaval fistula its effects on regional adaptation. Relations between expression (angiotensin II, insulin-like factor-I, endothelin-1), myocyte shape changes, collagen deposition were investigated at mRNA peptide levels adult pigs after...
Abstract —A growing body of evidence supports the existence a tissue-based renin-angiotensin system (RAS) in vasculature, but functional capacity vascular RAS was not investigated humans. In 28 normotensive healthy control subjects, metabolism angiotensins through tissue normal, low, and high sodium diets by measurement arterial-venous gradient endogenous angiotensin (Ang) I Ang II two different beds (forearm leg), combined with study 125 I-Ang kinetics. normal diet forearm extracted 36±6%...
Indirect measurement of renal vascular resistance by duplex Doppler waveform analysis was evaluated in relation to aging and some pathophysiological conditions. Baseline resistive index (RRI) (peak systolic frequency shift - lowest diastolic shift/peak shift) measured healthy controls aged 20 85 years analyzing the blood flow velocity interlobar arteries. RRI changes induced sympathetic activation (cold pressor test handgrip test) or fluid load were evaluated. Both repeatability...
The presence of mRNA for the essential components renin-angiotensin system (RAS) has been found in animal and human hearts. present study was designed to provide evidence existence a (functional) cardiac RAS.Twenty-four patients with atypical chest pain undergoing coronary angiography diagnostic purposes were investigated. production rate angiotensins estimated by measurement extraction 125I-angiotensin I II associated determination endogenous aortic sinus blood normal, low, or high sodium...
Growing evidence was collected that non-alcoholic liver fatty disease (NAFLD) is a risk factor for coronary atherosclerosis in terms of angiographic appearance, but its involvement acute syndromes still debated. We investigated the prevalence and severity NAFLD non-diabetic patients admitted ST-segment elevation myocardial infarction (STEMI) association with multi-vessel artery (CAD).Ninety-five consecutive to cardiac ICU STEMI were studied by ultrasound within 72 h from admission. graded...
The predictive role of Doppler Renal Resistive Index (RRI) for mortality was shown in chronic kidney disease. In selected populations intensive care unit (ICU), RRI predicts acute injury (AKI) occurrence and anticipates persistent AKI. No data are available about mortality. We investigated whether assay at AKI diagnosis could predict a 10-bed-mixed medical-surgical trauma ICU tertiary referral teaching hospital. association between discharge investigated.One hundred twenty-five 1512 patients...
In order to evaluate the interference of blood cells on platelet aggregation, spontaneous aggregation (SPA), ADP, and collagen-induced were investigated in whole by impedance method platelet-rich plasma (PRP) densitometric aggregometers. Stirring sample induced a significant decrease neutrophils (P less than 0.001) but no changes red cell (RBC) count. After collagen addition, further was observed, while RBC count unmodified. The occurrence SPA not different PRP. Platelet number hematocrit...
Low-grade inflammation facilitates the development of essential hypertension and target organ damage (TOD). Recently, human T-lymphocytes were shown to be endowed with a functional active renin-angiotensin system (RAS). We investigated whether in hypertensive patients selective angiotensin (Ang) II-driven upregulation T-cell RAS occurs it is differently modulated presence low-grade inflammation.T-lymphocytes obtained from 21 hypertensives (I-II World Health Organization class; 16 males, 5...