A5032837571- Agricultural safety and regulations
- Pesticide Residue Analysis and Safety
- Vitamin K Research Studies
- Effects and risks of endocrine disrupting chemicals
- Genetically Modified Organisms Research
- Pesticide Exposure and Toxicity
- Carcinogens and Genotoxicity Assessment
- melanin and skin pigmentation
- Animal Ecology and Behavior Studies
- Analytical Chemistry and Chromatography
- Mass Spectrometry Techniques and Applications
- Air Quality and Health Impacts
- Metabolomics and Mass Spectrometry Studies
- Biochemical Analysis and Sensing Techniques
- Advanced Chemical Sensor Technologies
- Glutathione Transferases and Polymorphisms
- Pharmaceutical Economics and Policy
- Pharmaceutical and Antibiotic Environmental Impacts
- Skin Protection and Aging
- Olfactory and Sensory Function Studies
- Occupational exposure and asthma
- Analytical chemistry methods development
- Pharmaceutical studies and practices
- Antioxidant Activity and Oxidative Stress
- Photochromic and Fluorescence Chemistry
University of Naples Federico II
2016-2025
European Food Safety Authority
2014-2024
MorphoSys (Germany)
2023
Istituto Nazionale di Fisica Nucleare, Sezione di Napoli
2015-2020
European Commission
2019
Radboud University Nijmegen
2018
University of Parma
2002-2012
Federico II University Hospital
2007
Czech Academy of Sciences, Institute of Experimental Medicine
2004
Institute of Occupational Safety
2004
This Guidance document describes harmonised risk assessment methodologies for combined exposure to multiple chemicals all relevant areas within EFSA's remit, i.e. human health, animal health and ecological areas. First, a short review of the key terms, scientific basis approaches assessing (eco)toxicology is given, including existing frameworks these assessments. background was evaluated, resulting in framework chemicals. The based on steps (problem formulation, assessment, hazard...
Abstract This guidance document is intended to assist the applicant in preparation and presentation of an application, as foreseen Article 7.6 Regulation (EC) No 1831/2003, for authorisation additives use animal nutrition. It specifically covers assessment safety users.
The aims of the present study were (1) to evaluate whether individual aldehydes resulting from lipid peroxidation can be measured in exhaled breath condensate, (2) assess influence sampling procedures on aldehyde concentrations, and (3) compare levels patients with stable, moderate severe, chronic obstructive pulmonary disease those smoking nonsmoking control subjects. Aldehydes (malondialdehyde, hexanal, heptanal, nonanal) by liquid chromatography-tandem mass spectrometry all samples...
Abstract A method for the simultaneous determination of several classes aldehydes in exhaled breath condensate (EBC) was developed using liquid chromatography/atmospheric pressure chemical ionization tandem mass spectrometry (LC/APCI‐MS/MS). EBC is a biological matrix obtained by relatively new, simple and noninvasive technique provides an indirect assessment pulmonary status. The measurement represents biomarker effect oxidative stress caused smoke, disease, or strong oxidants like ozone....
Oxidative stress is implicated in the pathogenesis of asthma, and clinical studies show an imbalance level oxidants to antioxidants subjects with asthma. Aldehydes glutathione are examples biomarkers oxidant-induced damage antioxidant status respectively. In study, we applied analytical techniques based on liquid chromatography for assessment aldehydes exhaled breath condensate children asthma control without Twelve were evaluated at exacerbation after 5 days therapy prednisone. At...
Aims: Urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) is a widely used biomarker of oxidative stress. However, variability between chromatographic and ELISA methods hampers interpretation data, this may increase should urine composition differ individuals, leading to assay interference. Furthermore, optimal sampling conditions are not well defined. We performed inter-laboratory comparisons 8-oxodG measurement mass spectrometric-, electrochemical- ELISA-based methods, using common...
A high quality eumelanin thin film featuring efficient reversibility of the water induced conductivity switch and biocompatibility was obtained,<italic>via</italic>ammonia-induced solid state polymerization a 5,6-dihydroxyindole film.
This paper investigates the production of biocrude via hydrothermal liquefaction (HTL) sewage sludge. Results on effect separation protocol oily/aqueous phases highlighted superior performance inertial over liquid–liquid extraction, with a yield 43% attained at HTL temperature 350 °C. Experimental results revealed that processing time exerts nonmonotonic maximum yields 35 and after 30 10 min times 300 °C, respectively. The best in terms energy recovery (about 59%) reduced content S 1%) are...
Abstract Following a request from the European Commission, EFSA was asked to deliver scientific opinion on proposed modification of terms authorisation feed additive consisting preparation canthaxanthin (CAROPHYLL® Red 10%), regarding addition new production route, by yeast Yarrowia lipolytica CBS 146148 and modify specifications substituting ethoxyquin 4.4% butylated hydroxytoluene (BHT) increasing limit for dichloromethane 80 mg/kg. The is already authorised as zootechnical breeder hens....
Abstract Following a request from the European Commission, Food Safety Authority was asked to deliver scientific opinion on proposed modification of terms authorisation canthaxanthin, regarding addition new production route, by yeast Yarrowia lipolytica CBS 146148. The additive is already authorised as sensory feed for use in chickens fattening, minor poultry species laying poultry, reared laying, ornamental fish, birds and breeder hens. Panel Additives Products or Substances used Animal...
Two novel classes of cavitand-based coordination cages 7a--j and 8a--d have been synthesized via self-assembly procedures. The main factors controlling cage (CSA) identified in (i) a P--M--P angle close to 90 degrees between the chelating ligand metal precursor, (ii) Pd Pt as centers, (iii) weakly coordinated counterion, (iv) preorganization tetradentate cavitand ligand. Calorimetric measurements dynamic (1)H (19)F NMR experiments indicated that CSA is entropy driven. temperature range...
The aim of the present study was to compare aldehyde levels resulting from lipid peroxidation in exhaled breath condensate (EBC) and induced sputum (IS) supernatant subjects with asthma chronic obstructive pulmonary disease (COPD). Aldehydes (malondialdehyde (MDA), acrolein, n -hexanal (C6), -heptanal (C7), -nonanal (C9), 4-hydroxynonenal (HNE) 4-hydroxyhexenal (HHE)) both biological fluids were measured by liquid chromatography-tandem mass spectrometry. MDA concentrations 132.5 nM...
Gellan gum (GG) was chemically modified with methacrylic moieties to produce a photocrosslinkable biomaterial ink, hereinafter called methacrylated GG (GGMA), improved physico-chemical properties, mechanical behavior and stability under physiological conditions. Afterwards, GGMA functionalized by incorporating two different bioactive compounds, naturally derived eumelanin extracted from the black soldier fly (BSF-Eumel), or hydroxyapatite nanoparticles (HAp), synthesized sol–gel method....
Melanins are pigments employed in food, cosmetic, and textile industries, manufactured by extraction from cuttlefishes. Their biotechnological production Streptomycetes, instead, has been poorly investigated so far. In this paper, for the first time, strain Streptomyces nashvillensis DSM 40314 was tested as an extracellular melanin producer investigating influence of diverse temperatures (26, 28, 30 °C) pH values (6.0 7.0) on bacterial growth, production, activity secreted tyrosinase, enzyme...
The aim of the present study was to investigate whether exhaled breath condensate (EBC), a fluid formed by cooling air, can be used as suitable matrix assess target tissue dose and effects inhaled cobalt tungsten, using EBC malondialdehyde (MDA) biomarker pulmonary oxidative stress. Thirty-three workers exposed Co W in workshops producing either diamond tools or hard-metal mechanical parts participated this study. Two urinary samples were collected: one before at end work shift. Controls...
Objective: To study the removal of linezolid, a new oxazolidinone antibiotic, by renal replacement therapy in patients with acute failure. Design: Prospective, single-dose pharmacokinetic study. Setting: Renal intensive care unit tertiary university hospital. Patients: Fifteen critically ill oliguric failure on (seven males, mean age 72.3 yrs, range 60–94; Acute Physiology and Chronic Health Evaluation II score 24.9, 18–36; mechanical ventilation ten 15). Interventions: All received 600 mg...
Melanin denotes a variety of mammalian pigments, including the dark electrically conductive eumelanin and reddish, sulphur-containing, pheomelanin. Organic (bio)electronics is showing increasing interests in exploitation, e.g. for bio-interfaces, but low conductivity material limiting development eumelanin-based devices. Here, first time, we report an abrupt increase electrical conductivity, revealing highest value presented to date 318 S/cm. This result, obtained via simple thermal...