A5001453843- Multiple Myeloma Research and Treatments
- Nutrition and Health in Aging
- Bone health and treatments
- Peptidase Inhibition and Analysis
- Frailty in Older Adults
- Toxic Organic Pollutants Impact
- Long-Term Effects of COVID-19
- Effects and risks of endocrine disrupting chemicals
- COVID-19 Clinical Research Studies
- Air Quality and Health Impacts
- Ubiquitin and proteasome pathways
- Cerebral Palsy and Movement Disorders
- Carcinogens and Genotoxicity Assessment
- Dental Implant Techniques and Outcomes
- Cardiovascular Function and Risk Factors
- Chemokine receptors and signaling
- Body Composition Measurement Techniques
- Health Systems, Economic Evaluations, Quality of Life
- Bone Metabolism and Diseases
- Cardiovascular and Diving-Related Complications
- Cancer, Hypoxia, and Metabolism
- Occupational health in dentistry
- Intensive Care Unit Cognitive Disorders
- Protease and Inhibitor Mechanisms
- Glycosylation and Glycoproteins Research
University of Parma
2013-2024
University of Insubria
2018
University of Washington
2015
Background: Sex differences have been demonstrated in the acute phase of coronavirus disease 2019 (COVID-19). Women (F) were found to be less prone develop a severe than men (M), but few studies assessed sex-differences Long-COVID-19 syndrome. Methods: The aim this prospective/retrospective study was characterize long-term consequences infection based on sex. For purpose, we enrolled 223 patients (89 F and 134 M) who infected by SARS-CoV-2. In illness, reported following symptoms more...
Dietary flavonoids and allied phenolic compounds are thought to be beneficial in the control of diabetes its complications, because their ability inhibit oxidative stress, protein glycation act as neuroprotectants. Following ingestion by humans, polyphenolic entering large intestine undergo extensive metabolism interaction with colonic microbiota it is metabolites catabolites parent that enter circulatory system. The aim this study was investigate inhibitory activity some microbiota-derived...
SummaryOropharyngeal dysphagia (OD) is a widespread clinical condition among older adults. Although it represents risk factor for malnutrition, dehydration and aspiration pneumonia, its assessment contribution to functional decline often ignored. The aim of the present study was estimate prevalence OD in large population non-institutionalized people evaluate relationship with malnutrition physical function. 10-item Eating Assessment Tool (EAT-10) Mini Nutritional Short Form (MNA-SF) were...
The gut microbiota could influence the pathophysiology of age-related sarcopenia through multiple mechanisms implying modulation chronic inflammation and anabolic resistance. aim this study was to compare fecal composition functionality, assessed by shotgun metagenomics sequencing, between two groups elderly outpatients, differing only for presence primary sarcopenia. Five sarcopenic subjects twelve non-sarcopenic controls, classified according lower limb function bioimpedance-derived...
Osteoblast impairment occurs within multiple myeloma cell infiltration into the bone marrow. Canonical Wnt signaling activation in osteoprogenitor cells is involved osteoblast formation through stabilization of dephosphorylated beta-catenin and its nuclear translocation. The effects on human mesenchymal/osteoprogenitor are unclear. In 60 patients checked, we found that among inhibitors, Dickkopf-1 secreted frizzled-related protein-3 were produced by cells. However, although or marrow plasma...
Abstract Background The “Sarcopenia and Physical Frailty in Older People: Multicomponent Treatment Strategies” (SPRINTT) project sponsored a multi-center randomized controlled trial (RCT) with the objective to determine effect of physical activity nutrition intervention for prevention mobility disability community-dwelling frail older Europeans. We describe here design feasibility SPRINTT intervention, including techniques used by interventionists identify those at risk malnutrition carry...
Abstract Background Ageing is accompanied by a progressive loss of skeletal muscle mass and strength, potentially determining the insurgence sarcopenia. Evidence suggests that motoneuron neuromuscular junction (NMJ) degeneration contribute to sarcopenia pathogenesis. Seeking for strategies able slow down progression, we investigated whether 2‐year mixed‐model training involving aerobic, strength balance exercises would be effective improving or preserving motoneuronal health NMJ stability,...
Aim This study aimed to investigate Italian dentists’ knowledge of and attitudes toward obstructive sleep apnea (OSA) in children. Methods An anonymous questionnaire was prepared using Google Forms sent dentists Italy through private social platforms. The first part the contained basic demographic data questions, second included items about pediatric OSA. Results A total 125 responses were collected within 1 month. interviews revealed gaps undergraduate post-graduate training on OSA,...
Biochar is currently garnering interest as an alternative to commercial fertilizer and a tool counteract global warming. However, its use increasingly drawing attention, particularly concerning the fine dust that can be developed during manufacture, transport use. This work aimed assess toxicity of particulate (<PM10) via in-vitro in-vivo experiments first step for evaluation values. As experiments, cell lines showed inhibition proliferation following reduction expression genes involved in...
Phomopsis leptostromiformis , and its teleomorph Diaporthe toxica is a lupin pathogen that causes stem blight in young lupins and, as saprophyte, has been detected on dead lupine material. Under favourable conditions, the fungus produces phomopsins (PHOs), family of macrocyclic hexapeptide mycotoxins capable binding tubulin through tripeptide side chain. The toxic effects appear largely confined to liver. In particular, ingestion PHO contaminated stubble linked lupinosis, debilitating...
Polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) are ubiquitous environmental pollutants. Exposure to these chemicals has been associated with developmental neurotoxicity, endocrine dysfunction, reproductive disorders. Humans wildlife generally exposed a mixture of pollutants, highlighting the need evaluate potential effects combined exposures. In this study, we investigated cytotoxic exposure two PBDEs PCBs in human neuronal cell line. 2,2′,4,4′‐Tetrabromodiphenyl...