Benedetta Ghezzi

ORCID: 0000-0002-8922-2915
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About
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Research Areas
  • Bone Tissue Engineering Materials
  • Dental materials and restorations
  • Salivary Gland Disorders and Functions
  • 3D Printing in Biomedical Research
  • Oral microbiology and periodontitis research
  • Bone and Dental Protein Studies
  • Crystallization and Solubility Studies
  • Dental Education, Practice, Research
  • Dental Implant Techniques and Outcomes
  • Cellular Mechanics and Interactions
  • Periodontal Regeneration and Treatments
  • Graphene and Nanomaterials Applications
  • Tissue Engineering and Regenerative Medicine
  • Electrospun Nanofibers in Biomedical Applications
  • Orthopaedic implants and arthroplasty
  • Mesenchymal stem cell research
  • Nanoplatforms for cancer theranostics
  • Dental Radiography and Imaging
  • Metabolomics and Mass Spectrometry Studies
  • Occupational health in dentistry
  • Connective tissue disorders research
  • Polymer Surface Interaction Studies
  • Head and Neck Cancer Studies
  • Library Science and Information Systems
  • Extracellular vesicles in disease

University of Parma
2016-2025

Institute of Materials for Electronics and Magnetism
2023-2024

Institute for Scientific Interchange
2024

National Research Council
2024

University of Bern
2023

The golden rule in tissue engineering is the creation of a synthetic device that simulates native tissue, thus leading to proper restoration its anatomical and functional integrity, avoiding limitations related approaches based on autografts allografts. emergence biocompatible materials has led production innovative scaffolds that, if combined with cells and/or bioactive molecules, can improve regeneration. In last decade, silk fibroin (SF) gained attention as promising biomaterial...

10.3390/bioengineering11020167 article EN cc-by Bioengineering 2024-02-09

The purpose of this work was to optimise printable polycaprolactone (PCL)/β-tricalcium phosphate (β-TCP) biomaterials with high percentages β-TCP endowed balanced mechanical characteristics resemble human cancellous bone, presumably improving osteogenesis.

10.1016/j.identj.2024.02.013 article EN cc-by-nc-nd International Dental Journal 2024-04-13

The number of retracted articles in the bio-medical field, including dentistry, is increasing. objective this study was to identify endodontic-related literature and outline their main characteristics. Medline Scopus databases were searched January 2024. Additional records identified by consulting online database www.retractiondatabase.org. Retracted concerning endodontic topics relative retraction notes retrieved relevant data extracted. Sixty identified, published between 2004 2022, with a...

10.23736/s2724-6329.24.05043-5 article EN Minerva Dental and Oral Science 2025-01-01

Cancer continues to pose a global threat, underscoring the urgent need for more effective and safer treatment options. Gold-based compounds have recently emerged as promising candidates due their diverse range of biological activities. In this study, three gold(III) complexes derived from thiosemicarbazone ligands been synthesized, fully characterized, including X-ray crystal structures. We conducted initial mode-of-action studies on DNA BSA, followed by comprehensive investigation into...

10.1016/j.jinorgbio.2023.112438 article EN cc-by-nc-nd Journal of Inorganic Biochemistry 2023-11-22

Aim This study aimed to investigate Italian dentists’ knowledge of and attitudes toward obstructive sleep apnea (OSA) in children. Methods An anonymous questionnaire was prepared using Google Forms sent dentists Italy through private social platforms. The first part the contained basic demographic data questions, second included items about pediatric OSA. Results A total 125 responses were collected within 1 month. interviews revealed gaps undergraduate post-graduate training on OSA,...

10.3389/fneur.2024.1279362 article EN cc-by Frontiers in Neurology 2024-02-19

The detection of salivary molecules associated with pathological and physiological alterations has encouraged the search novel non-invasive diagnostic biomarkers for oral health evaluation. While genomic, transcriptomic, proteomic profiles human saliva have been reported, its metabolic composition is a topic research: metabolites in submandibular/sublingual never analyzed systematically. In this study, samples whole, parotid, from 20 healthy donors, without dental or periodontal diseases,...

10.3390/metabo10080318 article EN cc-by Metabolites 2020-08-06

The production of 3D printed safety protection devices (SPD) requires particular attention to the material selection and evaluation mechanical resistance, biological surface roughness related accumulation bacteria viruses. We explored possibility adopt additive manufacturing technologies for respirator masks, responding sudden demand SPDs caused by emergency scenario pandemic spread SARS-COV-2. In this study, we developed different prototypes exclusively applying basic like fused deposition...

10.3390/polym13040617 article EN Polymers 2021-02-18

The present study aimed to analyze the behaviors of three intraoral scanners (IOSs): evaluating interdistance and axial inclination discrepancies in full-arch scans, predictable errors were searched.Six edentulous sample models with variable numbers dental implants used; reference data obtained a coordinate-measuring machine (CMM). Each IOS (i.e., Primescan, CS3600, Trios3) performed 10 scans per model (180 total scans). origin each scan body was used as point measure lengths inclinations....

10.1007/s00784-023-05011-4 article EN cc-by Clinical Oral Investigations 2023-04-12

INTRODUCTION: Analyzing highly-cited articles can provide a retrospective assessment of research evolution and predict future developments. The aim this study was to carry out bibliometric analysis the 100 most-cited in dentistry by authors with an Italian affiliation.EVIDENCE ACQUISITION: All published journals indexed under Scopus category "Dentistry" at least one author affiliated any institution were searched September 2022. selected relevant data extracted summarized. co-authorship...

10.23736/s2724-6329.23.04796-4 article EN Minerva Dental and Oral Science 2024-06-01

Photodynamic therapy (PDT) has been established as one of the most promising novel cancer therapies with fewer side-effects and enhanced efficacy compared to currently available conventional treatments. However, its application hindered by limitations that photosensitizers (PS) have. The combination PS metallic nanoparticles like platinum (PtNPs), can help overcome these intrinsic drawbacks. In this work, PtNPs natural photosensitizer riboflavin (RF) is proposed. are synthesized using RF...

10.1016/j.nanoms.2024.06.003 article EN cc-by-nc-nd Nano Materials Science 2024-07-01

Surface topography is one of the main factors controlling cell responses on implanted devices and a proper definition characteristics that optimize behavior may be crucial to improve clinical performances these implants. Substrate geometry known affect shape, as cells try their adhesion by adapting irregularities beneath, this in turn profoundly affects activity. In present study, we cultured murine calvaria MC3T3-E1 surfaces with pillars arranged hexagons two different spacings observed...

10.3390/nano9121701 article EN cc-by Nanomaterials 2019-11-28

The corneal endothelium is the inner mono-layered epithelium, fundamental for preserving hydration and transparency. However, molecular mechanisms that regulate endothelial cells (CEnCs), in particular regarding their proliferative capacity, have been only partially elucidated. CEnCs are quiescent vivo they easily undergo to mesenchymal transition (EnMT) vitro. This study aims analyze behavior expression vitro, either sub-confluent growing (S) or confluent (C) cultures. Primary rabbit human...

10.3390/ijms23105859 article EN International Journal of Molecular Sciences 2022-05-23

Testing of dental materials when in contact with innate immune cells has been so far hindered by the lack proper vitro models. Human primary monocyte-derived macrophages (MDMs) would be an excellent option to this aim. However, inability detach them from tissue culture plates contrast possibility on biomaterials. The goal present work is and validate innovative protocol obtain MDMs peripheral blood monocytes, reseed biomaterials without altering their viability phenotype.We differentiated...

10.1016/j.jds.2023.01.020 article EN cc-by-nc-nd Journal of Dental Sciences 2023-02-13

New technologies can facilitate the transition from pre-clinical to clinical settings. We investigate students' satisfaction with a novel learning method adopted in access cavity exercises.Students performed their on inexpensive, in-house 3D printed teeth. Their performances were evaluated by scanning prepared teeth an intraoral scanner and visualized using mesh processing software. Then, same software was used align tooth student teacher's one for self-assessment purposes. Students asked...

10.3390/dj11060152 article EN cc-by Dentistry Journal 2023-06-13

The study of the intimate connection occurring at interface between cells and titanium implant surfaces is a major challenge for dental materials scientists. Indeed, several imaging techniques have been developed optimized in last decades, but an optimal method has not described yet. combination scanning electron microscopy (SEM) with focused ion beam (FIB), represents pioneering interesting tool to allow investigation relationship biomaterials, including titanium. However, caveats...

10.1371/journal.pone.0272486 article EN cc-by PLoS ONE 2022-08-02

Current biomedical research is centered on the study of nanomaterials and their effects in biological environments. In particular, there an increasing interest TiO₂ nanostructures for applications such as drug delivery or implant materials. this framework, we present a Chemical Vapour Deposition process to synthesize titanium dioxide nanowires (NWs) commercially pure substrate test material Vitro culture murine osteoblast-like MC3T3-E1 cells. A physical-morphological, structural...

10.1166/jnn.2019.16350 article EN Journal of Nanoscience and Nanotechnology 2019-03-26

Abstract Background Carious/Non-carious cervical lesions with gingival recessions may require both dental and periodontal reconstructive therapy, where flaps/grafts be placed in contact a filling material. Human Gingival Fibroblasts (HGF-1) response during the early phase of healing could vary according to procedures employed cure composite. Moreover, oxygen diffusion into composite inhibits polymerization reaction, creating an oxygen-inhibited layer (OIL) that presents residual unreacted...

10.1186/s12903-024-04418-z article EN cc-by BMC Oral Health 2024-06-03
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