A5012983949- Asthma and respiratory diseases
- Air Quality and Health Impacts
- Occupational and environmental lung diseases
- Inhalation and Respiratory Drug Delivery
- Occupational exposure and asthma
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Climate Change and Health Impacts
- Occupational Health and Safety Research
- Indoor Air Quality and Microbial Exposure
- Noise Effects and Management
- Allergic Rhinitis and Sensitization
- Vitamin D Research Studies
- Carcinogens and Genotoxicity Assessment
- Nanoparticles: synthesis and applications
- Neonatal Respiratory Health Research
- Antifungal resistance and susceptibility
- Mycotoxins in Agriculture and Food
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pleural and Pulmonary Diseases
- Respiratory and Cough-Related Research
- Radiation Dose and Imaging
- Energy and Environment Impacts
- Air Quality Monitoring and Forecasting
- Respiratory Support and Mechanisms
- Medical Malpractice and Liability Issues
University of Aberdeen
2012-2023
Institute of Occupational Medicine
1990-2022
King's College London
2022
University of the Highlands and Islands
2014
Royal Aberdeen Children's Hospital
2011
King's College Hospital
1976-2011
Avon Medical Centre
2011
The King's College
2011
Brigham and Women's Hospital
2007
Woodrow Wilson International Center for Scholars
2006
Asbestos is a commercial term for group of fibrous minerals often associated with the development pulmonary interstitial fibrosis (asbestosis), lung cancer, and malignant mesothelioma in occupationally exposed individuals. The pathogenicity different forms asbestos varies—long, thin amphibole fibers are most pathogenic, particularly induction mesothelioma. Available data do not support concept that low-level exposure to health hazard buildings schools. concentration air, type asbestos, size...
Background:Maternal intake of vitamin D in pregnancy is a potentially modifiable but understudied risk factor for the development asthma children. Objective:We investigated whether maternal associated with decreased risks wheezing symptoms young Design:Subjects were from birth cohort recruited utero primary objective identifying associations between diet during and allergies A random sample 2000 healthy pregnant women was while attending antenatal clinics at Aberdeen Maternity Hospital,...
<h3>BACKGROUND</h3> Particulate air pollution has been associated with excess deaths from, and increases in hospital admissions for, cardiovascular disease among older people. A study was undertaken to determine whether this may be a consequence of alterations the blood, secondary pulmonary inflammation caused by action fine particles on alveolar cells, repeatedly measuring haematological factors people relating them measurements exposure airborne particles. <h3>METHODS</h3> One hundred...
New developments in technology usually entail some hazard as well advantage to a society. Hazard of material translates into risk by exposure humans and/or their environment the agent question, and is reduced control exposure, guided regulation based on understanding mechanisms harm. We illustrate risks relating causation diseases associated with aerosols combustion particles asbestos, leading paradigms particle toxicity, discuss analogies potential manufactured nanoparticles (NPs). review...
To investigate the associations between Parkinson's disease and other degenerative parkinsonian syndromes environmental factors in five European countries.A case-control study of 959 prevalent cases parkinsonism (767 with disease) 1989 controls Scotland, Italy, Sweden, Romania Malta was carried out. Cases were defined using United Kingdom Disease Society Brain Bank criteria, those drug-induced or vascular dementia excluded. Subjects completed an interviewer-administered questionnaire about...
OBJECTIVES To measure the concentrations of particles less than 100 nm diameter and oxides nitrogen generated by cooking with gas electricity, to comment on possible hazards health in poorly ventilated kitchens. METHODS Experiments electric rings, grills, ovens were used compare different procedures. Nitrogen (NO x ) measured a chemiluminescent ML9841A NO analyser. A TSI 3934 scanning mobility particle sizer was average number concentration size distribution aerosols range 10–500 nm. RESULTS...
Background The environmental factors responsible for recent increases in the prevalence of asthma and atopic disease have been assumed to act after birth. Their possible effects on fetal immune development utero not investigated systematically, although sensitization allergens may occur before Objective This prospective study determined whether risk disease, namely family history maternal smoking, birth order, or dietary intake antioxidant vitamins, exert antenatal system that predispose...
Associations between maternal vitamin E, D and zinc intakes during pregnancy asthma, wheeze eczema in 5-year-old children have previously been reported. A study was undertaken to investigate whether intake of specific foods is associated with asthma allergic outcomes the same children.A longitudinal birth cohort conducted 1,924 born women recruited pregnancy. Maternal diet assessed by food frequency questionnaire (FFQ). Cohort were followed up at 5 years symptom FFQ. Food groups interest...
It has been postulated that dietary antioxidants may influence the expression of allergic diseases and asthma. To test this hypothesis a case-control study was performed, nested in cross sectional random sample adults, to investigate relationship between disease antioxidants.The performed rural general practices Grampian, Scotland. A validated questionnaire used measure food intake cases, defined, firstly, as people with seasonal allergic-type symptoms and, secondly, those bronchial...
We have previously reported an association between reduced maternal vitamin E intake during pregnancy and wheezing in 2-yr-old children.To assess whether nutrient is associated with asthma-related outcomes children aged 5 yr.A longitudinal cohort study of 1,861 born to women recruited followed up at yr.Maternal status was assessed by a food frequency questionnaire plasma levels. Respiratory questionnaires were completed yr invited for measurement spirometry skin-prick testing.Symptom data...
Two thousand women were recruited for a prospective investigation of the influence maternal antioxidant intake in pregnancy on development asthma and eczema children. A food frequency questionnaire was used to characterize diet during blood levels measured. Postal questionnaires follow up 1,924 singleton children born cohort at 6, 12, 24 months age. There no associations between wheezing symptoms children's first year. In second year, vitamin E negatively associated with wheeze absence...
This study addresses the causes of increases in childhood asthma and allergic disease. On basis an observed inverse relationship between family size disease or atopy, it has been proposed that a fall common infections may have responsible for rise asthma. was undertaken to investigate relationships reported test hypothesis two is consequence infections.Data had obtained 1964 cross sectional survey random sample Aberdeen schoolchildren aged 10 14 year. Records presence absence asthma, eczema,...
Specific surveys of the air for Aspergillus fumigatus were carried out in rural and urban situations over a 2-year period. Overall, low concentrations spores recorded with higher incidence during "winter" months. Counts open hospital ward showed similar fluctuations, indoor counts being consistently lower. Plant debris form compost heaps stacks hay straw baled high moisture content which self-heating occurs, produces large numbers may be liberated into causing but localized if disturbed. The...
In a detailed study of factors associated with death from bronchial asthma outside hospital 90 patients were investigated. The fatal attack was typically short and most likely to occur in long history. Deaths often occurred before effective medical help obtainable, but occasionally the patient or doctor underestimated severity attack. Patients especially at risk those recently discharged after previous These deaths might be prevented by better education, self-admission service for selected...
Particle toxicology arose in order to understand the mechanisms of adverse effects 3 major particle types that had historically exerted greatest toll ill-health—quartz, coal and asbestos. By middle last century rat inhalation studies been carried out pathology documented, but true mechanistic did not really take off until 1970s when cell culture techniques became available. 1980s glass fibres were a focus interest attempts develop structure-toxicity paradigm centred on biopersistence. In...
An increase in prevalence of wheezing illness the UK has coincided with a reduction consumption natural antioxidants, which may modulate lung's response to oxidant stress, limiting expression airway inflammation and respiratory symptoms. The hypothesis that intakes plasma levels antioxidants would be determinants adult-onset was tested. A nested case-control study conducted 94 cases wheeze 203 controls aged 39-45 yrs identified 30-yr follow-up survey. Antioxidant intake measured by food...