A5072519365- Retinal Imaging and Analysis
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Chemical Synthesis and Analysis
- Corneal surgery and disorders
- Bladder and Urothelial Cancer Treatments
- Ophthalmology and Visual Impairment Studies
- Metal complexes synthesis and properties
- Systemic Lupus Erythematosus Research
- Urinary and Genital Oncology Studies
- Radiopharmaceutical Chemistry and Applications
- Corneal Surgery and Treatments
- Epigenetics and DNA Methylation
- COVID-19 Clinical Research Studies
- Antioxidant Activity and Oxidative Stress
- Musculoskeletal pain and rehabilitation
- Retinal and Optic Conditions
- Ferroptosis and cancer prognosis
- Retinal and Macular Surgery
- Lung Cancer Research Studies
- Sexual Differentiation and Disorders
- Esophageal Cancer Research and Treatment
- Circular RNAs in diseases
- Synthetic Organic Chemistry Methods
- Chemical Thermodynamics and Molecular Structure
Vista Klinik
2025
University of Basel
1966-2025
Institute of Molecular and Clinical Ophthalmology Basel
2021-2025
Charité - Universitätsmedizin Berlin
2025
Hospitais da Universidade de Coimbra
2023-2024
Association for Innovation and Biomedical Research on Light and Image
2023-2024
Semmelweis University
2021-2024
University Hospital of Basel
2021-2023
Universitätskinderklinik
1966-1968
Age-related macular degeneration (AMD) is characterised by a progressive loss of central vision. Intermediate AMD risk factor for progression to advanced stages categorised as geographic atrophy (GA) and neovascular AMD. However, rates vary between individuals. Recent advances in imaging computing technologies have enabled deep phenotyping intermediate The aim this project utilise machine learning (ML) statistical modelling an innovative approach discover novel features accurately quantify...
Stargardt disease is a currently untreatable, inherited neurodegenerative that leads to macular degeneration and blindness due loss-of-function mutations in the ABCA4 gene. We have designed dual adeno-associated viral vector encoding split-intein adenine base editor correct most common mutation (c.5882G>A, p.Gly1961Glu). optimized editing human models, including retinal organoids, induced pluripotent stem cell-derived pigment epithelial (RPE) cells, as well adult explants RPE/choroid vitro....
Purpose: The purpose of this study was to evaluate the feasibility and utility optical coherence tomography (OCT)-based, targeted microperimetry grids in assessing focal lesions intermediate age-related macular degeneration (iAMD). Methods: multicenter, prospective PINNACLE enrolled 395 patients with iAMD aged 55 90 years across 12 international sites. Participants underwent imaging, including OCT microperimetry, every 4 months over 3 years. Deep learning algorithms detected changes images,...
Muscle-invasive bladder cancer (MIBC) presents significant treatment challenges. Antibody-drug conjugates (ADCs) targeting HER2, TROP-2, and NECTIN4 offer promising therapeutic options. This study examined the spatial expression of in MIBC metastases, their association with molecular subtypes, clinical outcomes. Formalin-fixed, paraffin-embedded (FFPE) tissue samples from 251 patients were analyzed using immunohistochemistry microarrays (TMA). Expression patterns between tumor front (TF)...
The purpose of this study was to describe, validate, and compare the contrast sensitivity functions (CSFs) acquired with novel quick CSF (qCSF) method from patients early intermediate age-related macular degeneration (eAMD iAMD) healthy controls.
Thyroid transcription factor 1 (TTF-1) is a well-established independent prognostic in lung adenocarcinoma (LUAD), irrespective of stage. This study aims to determine if TTF-1's impact solely based on histomorphological differentiation (tumor grading) or it independently relates biologically more aggressive phenotype. We analyzed large bi-centric LUAD cohort accurately assess value relation tumor grade.
Purpose: To investigate and compare novel volumetric microperimetry (MP)–derived metrics in intermediate age-related macular degeneration (iAMD), as current MP show high variability low sensitivity. Methods: This is a cross-sectional analysis of baseline data from the multicenter, prospective PINNACLE study (ClinicalTrials.gov NCT04269304). The Visual Field Modeling Analysis (VFMA) software an open-source implementation (OSI) were applied to calculate MP-derived hill-of-vison (HOV) surface...
Background: Acute myocardial injury (AMJ), assessed by elevated levels of cardiac troponin, is associated with fatal outcome in coronavirus disease 2019 (COVID-19). However, the role acute cardiovascular (CV) events defined clinical manifestation rather than sole elevations biomarkers unclear hospitalized COVID-19 patients. Objective: The aim this study was to investigate clinically manifest CV Methods: From 1 March 2020 5 January 2021, we conducted a multicenter, prospective,...
To assess potential differences between central and eccentric cones in the aberrometric corneal profile visual keratometric outcomes 6 months after intracorneal ring segment (ICRS) implantation for keratoconus.This study compared two groups consisting of 12 patients each, with or keratoconus who were treated femtosecond laser-assisted Keraring implantation. Uncorrected (UDVA) corrected (CDVA) distance acuity, readings higher order aberrations (HOAs) including high root mean square (HOARMS),...
Abstract Background: Thyroid transcription factor 1 (TTF-1) is expressed in 70% to 80% of lung adenocarcinomas (LUAD). Several papers revealed that TTF-1 expression associated with better patient outcomes independent the tumor stage. However, it unknown whether prognostic impact only results from a different growth pattern (tumor grading) or independently biologically more aggressive phenotype. Thus, we analyzed large bi-centric cohort LUAD assume true value relation grade. Methods: We...
The objective of this study was to evaluate retinal sensitivity in subfields and its association with the novel quantitative contrast function (qCSF) patients early age-related macular degeneration (eAMD), intermediate AMD (iAMD), healthy controls.
<b><i>Introduction:</i></b> The aim of this study was to describe the design and participants’ baseline characteristics a prospective natural history geographic atrophy (GA) secondary age-related macular degeneration. <b><i>Methods:</i></b> optical coherence tomography (OCT) microperimetry biomarker evaluation in patients with GA (OMEGA) conducted at tertiary referral center (ClinicalTrials.gov identifier: NCT05963646). Participants were...
Abstract After degradation of the Ni 2+ complex val 5 ‐angiotensin II‐asp 1 ‐β‐amid by H 2 O peptide fragments were separated high voltage electrophoresis and ion exchange. The hydrolyzed amino acids determined method Stein & Moore.
Purpose To examine the effect of prolactin (PRL) on human corneal stromal fibroblasts (CSFs), derived from healthy individuals and keratoconus (KC) patients, in vitro , specifically assessing physiological elevated PRL concentrations as apparent during pregnancy. Methods Eye bank corneas 3 female male well buttons KC patients were utilized for this study. The endothelium cornea was removed with sterile surgical scalpels, probes washed repeatedly Dulbecco’s PBS corneoscleral rims trimmed off....