A5025927895- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Optical Coherence Tomography Applications
- Retinal and Macular Surgery
- Medical Image Segmentation Techniques
- AI in cancer detection
- Retinal and Optic Conditions
- Systemic Lupus Erythematosus Research
- Lipid metabolism and biosynthesis
- Generative Adversarial Networks and Image Synthesis
- Corneal surgery and disorders
- Ocular and Laser Science Research
- Hibiscus Plant Research Studies
- Photoacoustic and Ultrasonic Imaging
- Virtual Reality Applications and Impacts
- Psidium guajava Extracts and Applications
- Phytochemistry and biological activities of Ficus species
- Surgical Simulation and Training
- Advanced Vision and Imaging
- Geological Modeling and Analysis
- Thermoregulation and physiological responses
- Endoplasmic Reticulum Stress and Disease
- Kruppel-like factors research
- Sphingolipid Metabolism and Signaling
University Hospital of Basel
2021-2025
University of Basel
2021-2025
Moorfields Eye Hospital NHS Foundation Trust
2023-2025
University College London
2023-2025
Institute of Molecular and Clinical Ophthalmology Basel
2021-2024
Moorfields Eye Hospital
2023
Diffusion models have shown impressive performance for generative modelling of images. In this paper, we present a novel semantic segmentation method based on diffusion models. By modifying the training and sampling scheme, show that can perform lesion medical To generate an image specific segmentation, train model ground truth use as prior during in every step process. With given stochastic process, distribution masks. This property allows us to compute pixel-wise uncertainty maps implicit...
Abstract The eye and the heart are two closely interlinked organs, many diseases affecting cardiovascular system manifest in eye. To contribute to understanding of blood flow propagation towards retina, we developed a method acquire electrocardiogram (ECG) coupled time-resolved dynamic optical coherence tomography (OCT) images. This allows for continuous synchronised monitoring cardiac cycle retinal dynamics. OCT measurements were used calculate profiles using fringe washout analysis....
To evaluate the degenerative findings including cistern formation in premacular vitreous using optical coherence tomography.A novel enhanced imaging method by which four A-scans at each position were averaged before Fourier transform increased image quality per frame so that subsequent registration for averaging could occur. Analysis of B-scans and volume-rendered images eyes subjects various ages was performed.There 43 23 ranging age from to 68 years. The texture suggests specific...
Purpose: Optical coherence tomography (OCT) representations in clinical practice are static and do not allow for a dynamic visualization quantification of blood flow. This study aims to present method analyze retinal flow dynamics using time-resolved structural OCT. Methods: We developed novel imaging protocols acquire video-rate OCT B-scans (1024 × 496 pixels, 10 degrees field view) at four different sensor integration times (integration time 44.8 µs nominal A-scan rate 20 kHz, 22.4 40 11.2...
The purpose of this study was to develop a deep learning algorithm for detecting and quantifying incomplete retinal pigment epithelium outer atrophy (iRORA) complete (cRORA) in optical coherence tomography (OCT) that generalizes well data from different devices validate an intermediate age-related macular degeneration (iAMD) cohort.
Purpose: To explore genetic determinants specific to reticular pseudodrusen (RPD), and compare these with associations for drusen. Setting: Participants RPD, drusen, or controls from the UK Biobank (UKBB), a large, multisite, community-based cohort study. Methods: A previously validated deep learning framework was deployed on 169,370 optical coherence tomography (OCT) volumes UKBB identify cases RPD and/or drusen without phenotypes. Cases were included if they 60 years older, at least 5...
To evaluate the anatomic changes in vitreous associated with evolving posterior detachment over macula.A novel scanning method by which four A-scans at each position were averaged before Fourier transform that boosted image quality sufficiently such frame averaging could occur. B-scans and volume rendered images of eyes evidence any partial separation macular regions evaluated.There 43 23 subjects particular attention paid to findings seven various stages occurring macula. In from young no...
To evaluate the feasibility of automated segmentation pigmented choroidal lesions (PCLs) in optical coherence tomography (OCT) data and compare performance different deep neural networks.Swept-source OCT image volumes were annotated pixel-wise for PCLs background. Three network architectures applied to data: multi-dimensional gated recurrent units (MD-GRU), V-Net, nnU-Net. The nnU-Net was used two-dimensional (2D) versus three-dimensional (3D) predictions.A total 121 analyzed (100 normal 21...
Optical coherence tomography angiography (OCTA) enables three-dimensional, high-resolution, depth-resolved flow to be distinguished from non-vessel tissue signals in the retina. Thus, it quantification of 3D surface area retinal vessel signal. Despite widespread use OCTA, no representative spatially rendered reference data are published. In this study, OCTA areas 203 eyes 107 healthy participants were measured domain. A Generalized Linear Model (GLM) model analysis was performed investigate...
Abstract Cynomolgus monkeys exhibit human-like features, such as a fovea, so they are often used in non-clinical research. Nevertheless, little is known about the natural variation of choroidal thickness relation to origin and sex. A combination deep learning deterministic computer vision algorithm was applied for automatic segmentation foveolar optical coherence tomography images cynomolgus monkeys. The main evaluation parameters were surface area directed from deepest point on OCT within...
Abstract Supervised deep learning (DL) algorithms are highly dependent on training data for which human graders assigned, example, optical coherence tomography (OCT) image annotation. Despite the tremendous success of DL, due to judgment, these ground truth labels can be inaccurate and/or ambiguous and cause a selection bias. We therefore investigated impact size variable numbers predictive performance same DL architecture repeated each experiment three times. The largest dataset delivered...
Abstract Cynomolgus monkeys ( Macaca fascicularis ) are commonly used in pre-clinical ocular studies. However, studies that report the morphological features of macaque retina based only on minimal sample sizes; therefore, little is known about normal distribution and background variation. This study was conducted using optical coherence tomography (OCT) imaging to investigate variations retinal volumes healthy cynomolgus effects sex, origin, eye side establish a comprehensive reference...
Abstract The fovea is a depression in the center of macula and site highest visual acuity. Optical coherence tomography (OCT) has contributed considerably elucidating pathologic changes now being considered as an accompanying imaging method drug development, such antivascular endothelial growth factor its safety profiling. Because animal numbers are limited preclinical studies automatized image evaluation tools have not yet been routinely employed, essential reference data describing...
Currently, most medical image data, such as optical coherence tomography (OCT) images, are displayed in two dimensions on a computer screen. Advances information technology have contributed to the growing storage of these data electronic form. However, usually processed only locally site. To overcome hurdles, cyberspace virtual reality (csVR) application was validated, which interactive OCT were presented simultaneously geographically distant sites (Lucerne, London, and Barcelona) where...
<b><i>Introduction:</i></b> The aim of this study was to describe the design and participants’ baseline characteristics a prospective natural history geographic atrophy (GA) secondary age-related macular degeneration. <b><i>Methods:</i></b> optical coherence tomography (OCT) microperimetry biomarker evaluation in patients with GA (OMEGA) conducted at tertiary referral center (ClinicalTrials.gov identifier: NCT05963646). Participants were...
Abstract The eye and the heart are two closely interlinked organs, many diseases affecting cardiovascular system manifest in eye. To contribute to understanding of blood flow propagation towards retina, we developed a method acquire electrocardiogram (ECG) coupled time-resolved dynamic optical coherence tomography (OCT) images. This allows for continuous synchronised monitoring cardiac cycle retinal dynamics. OCT measurements were used calculate profiles using fringe washout analysis....
Abstract Purpose To measure the retinal oxygen metabolic function with oximetry (RO) in patients choroideremia (CHM) and compare these findings retinitis pigmentosa (RP) controls. Methods Prospective observational study including 18 eyes of 9 molecularly confirmed CHM (9♂; 40.2 ± 21.2 years (mean SD), 77 from 39 RP (15♀ 24♂; 45.6 14.7 years) 100 53 controls (31♀ 22♂; 13.4 years). Main outcome parameters were mean arterial (A-SO 2 ; %), venular (V-SO %) saturation, their difference (A-V SO...
High anisotropy in volumetric medical images can lead to the inconsistent quantification of anatomical and pathological structures. Particularly optical coherence tomography (OCT), slice spacing substantially vary across within datasets, studies, clinical practices. We propose standardize OCT volumes less anisotropic by conditioning 3D diffusion models with en face scanning laser ophthalmoscopy (SLO) imaging data, a 2D modality already commonly available practice. trained evaluated on data...
To study the ocular and systemic factors affecting optic nerve head (ONH) perfusion data as obtained using a commercially available laser speckle flowgraphy (LSFG) device in cohort of Caucasian subjects without diseases. Also, to assess intrasession repeatability intersession reproducibility ONH, macular, retinal, choroidal perfusion.
Purpose: To analyze natural variability in pupillary contractility with dynamic volume-rendered optical coherence tomography (OCT) pupillometry regarding iris color, age, and sex healthy Caucasian participants. Methods: The intrapupillary spaces (IPSs) derived from anterior segment swept-source OCT of 71 eyes were retrospectively analyzed. Baseline scotopic photopic volumes the functional parameters ejection fraction (PEF), three-dimensional (3D) contractility, relative light response (RLR)...
To assess intrapupillary space (IPS) changes in healthy subjects with regard to decreased iris motility patients pseudoexfoliation glaucoma (PEXG) or non-arteritic anterior ischaemic optic neuropathy (NAION) a feasibility study clinical environment.Scotopic and photopic IPS measurements using three-dimensionally rendered swept-source optical coherence tomography (SS-OCT) data were obtained compared for all subjects. Intrapupillary parameters evaluated such as absolute volumetric differences,...
This study aimed to provide volumetric choroidal readings regarding sex, origin, and eye side from healthy cynomolgus monkey eyes as a reference database using optical coherence tomography (OCT) imaging. A machine learning (ML) algorithm was used extract the choroid OCT data. Classical computer vision methods were then applied automatically identify deepest location in foveolar depression. The thickness determined this point. total of 374 203 macaques Asian Mauritius origin included...