A5009279620- Glaucoma and retinal disorders
- Retinal Diseases and Treatments
- Ophthalmology and Eye Disorders
- Retinal Imaging and Analysis
- Ocular Surface and Contact Lens
- Neurological Disease Mechanisms and Treatments
- Facial Trauma and Fracture Management
- Corneal surgery and disorders
- Optical Coherence Tomography Applications
- Nasolacrimal Duct Obstruction Treatments
- Burn Injury Management and Outcomes
- Cardiovascular and Diving-Related Complications
- Retinal and Optic Conditions
- Corneal Surgery and Treatments
- Cerebral Venous Sinus Thrombosis
- Acute Ischemic Stroke Management
- Child Abuse and Related Trauma
- Ocular Diseases and Behçet’s Syndrome
- Cleft Lip and Palate Research
- Cancer and Skin Lesions
- Neurological and metabolic disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Retinal and Macular Surgery
- Intracranial Aneurysms: Treatment and Complications
- Intraoperative Neuromonitoring and Anesthetic Effects
Karolinska Institutet
2021-2025
S:t Eriks Ögonsjukhus
2021-2025
University of Basel
2022-2025
University Hospital of Basel
2022-2024
University of Lucerne
2016-2022
Kantonsspital Aarau
2018-2022
Medignition (Switzerland)
2018
University Hospital of Zurich
2013-2016
University of Koblenz and Landau
2014
Klinikverbund Südwest
2006
Neuroinflammation is a critical and targetable pathogenic component of neurodegenerative diseases, including glaucoma, the leading cause irreversible blindness. Valproic acid has previously been demonstrated to reduce neuroinflammation neuroprotective in number experimental settings. To determine whether valproic can limit retinal protect neurons we used an ex vivo retina explant (axotomy) model isolate resident glial responses from blood-derived monocytes. Neuroinflammatory status was...
Abstract Supervised deep learning (DL) algorithms are highly dependent on training data for which human graders assigned, example, optical coherence tomography (OCT) image annotation. Despite the tremendous success of DL, due to judgment, these ground truth labels can be inaccurate and/or ambiguous and cause a selection bias. We therefore investigated impact size variable numbers predictive performance same DL architecture repeated each experiment three times. The largest dataset delivered...
Glaucoma is a leading cause of blindness and characterized by the progressive dysfunction irreversible death retinal ganglion cells. We aimed to identify shared differentially expressed genes (DE genes) between different glaucoma relevant models cell injury using existing RNA-sequencing data, thereby discovering targets for neuroprotective therapies. A comparison DE from publicly available transcriptomic datasets identified 12 genes. The Comparative Toxicogenomics Database (CTD) was screened...
Purpose: To investigate whether nicotinamide (NAM) modulates retinal vasculature in glaucoma. Methods: This was a prospective controlled clinical trial investigating animal and human histopathology. Participants included normotensive ocular hypertensive rats, postmortem tissue, glaucoma patients (n = 90), healthy controls 30). The study utilized histopathology, computer-assisted analysis, optical coherence tomography angiography (OCTA), NAM treatment. main outcome measures vascular...
Purpose To evaluate differences in postoperative central macular thickness, volume, corrected distance visual acuity (CDVA), and number of intravitreal anti-vascular endothelial growth factor (VEGF) injections between conventional femtosecond laser–assisted cataract surgery wet age-related degeneration (AMD). Setting Tertiary referral center, Lucerne, Switzerland. Design Retrospective case series. Methods Consecutive patients with AMD were enrolled January 2010 December 2015. Associations...
Postmortem pathological examinations, animal studies, and anecdotal reports suggest that coronavirus disease 2019 (COVID-19) could potentially affect intraocular tissue. However, published evidence is scarce conflicting. In our study, we screened 100 eyes of 50 patients hospitalized for COVID-19. Relevant medical ophthalmological history was assessed as well symptoms, laboratory results, specific treatments, clinical course, outcome. Ophthalmic exams including assessment best corrected...
Purpose: Impaired ocular blood flow has been associated with the etiopathogenesis of glaucoma. Topical brimonidine lowers intraocular pressure, a major glaucoma risk factor. However, brimonidine's influence on retinal remains to be fully elucidated. Our aim was compare effect topical and brinzolamide administration velocity in second third order vessels healthy adults using function imager. Methods: In 10 probands between 23 32 years age, one eye randomly selected receive 2 treatment rounds...
The aim of this study was to describe and evaluate double PreserFlo MicroShunt implantation as a modified micro-invasive glaucoma surgery technique retrospectively compare the outcomes in cohort patients with single or implantation.A retrospective data analysis 57 who consecutively underwent performed. Medical records were examined for patients' demographics, type, intraocular pressure (IOP), medication, complications, re-interventions. Two groups (n = 29) 28) formed, compared. In cases...
The authors report 2 consecutive adult male patients, aged 61 and 38 years, who presented with painless unilateral proptosis. Their past medical histories were negative for asthma, allergies, Graves disease. On examination, the nose bridge of eldest patient was clearly enlarged. Computed tomography scans orbits paranasal sinuses showed in both patients same radiologic pattern hyperdense ethmoidal opacifications expansion inferomedial orbital floor. Histopathological analysis cells mucosa...
<b>Background:</b> Patients with congenital superior oblique palsy tend to adopt a head tilt the contralateral side maintain binocular single vision. It has long been recognised that facial asymmetries may be caused by tilt. The aim of this study was describe effect habitual due on dental occlusion. <b>Patients and methods:</b> designed as descriptive cohort study. Ten patients (3 female, 7 male; mean age 51.7 (y) ± 15.8 SD, ranging from 19 69 (y)) underwent orthodontic examination....
<b>Background:</b> Inferior oblique muscle overaction of variable amounts is usually present with congenital superior palsy. anteriorization has been described as a suitable surgical procedure in this entity. The aim study was to investigate the effect inferior patients palsy on vertical, torsional and horizontal alignment. <b>Patients Methods:</b> designed an institutional retrospective cohort study. 45 (15 female, 30 male; mean age 36 years ± 19.2 SD, ranging from 6 75 years) underwent...
It has been observed that an intraocular pressure (IOP) altering intervention in one eye is followed by a consensual response the untreated fellow eye. The underlying mechanisms remain unclear. Involvement of neuronal, cytokine, and hormonal regulation aqueous humor dynamics, as well improved treatment adherence or systemic absorption topically administered medical compounds, have suggested. Our aim was to investigate short-term effects unilateral micropulse transscleral laser therapy on IOP...
PurposeTo investigate the clinical outcomes of micropulse transscleral laser therapy (MP-TLT) in a cohort glaucoma patients, including safety profile, post-operative transient intraocular pressure (IOP) spikes, long-term efficacy and prognostic factors terms IOP-lowering.MethodsThis was retrospective observational study. Medical records all patients who consecutively underwent MP-TLT between May 2019 February 2023 at tertiary referral centre were scrutinised relevant data retrospectively...
Euphorbia is a plant family of more than 2000 species growing all around the globe. The sap many plants highly toxic and has been reported to cause severe inflammatory reactions on contact with skin or ocular surface [1]. Typical findings include pain, photophobia, diminished visual acuity as well epithelial defects, stromal edema, Descemetʼs membrane folds, anterior uveitis. dimensions damage clinical course may vary depending type extent exposure While patients fully recover within 1 – 2...
We aimed to test for feasibility of volume-rendered optical coherence tomography angiography (OCTA) as a novel method assessing/quantifying retinal vasculature during ocular procedures and explore the potential intraoperative use. Thirty patients undergoing periocular anaesthesia were enrolled, since published evidence suggests reduction in blood flow. Retinal perfusion was monitored based on planar OCTA image-derived data provided by standard quantification algorithm...
Superficial intracranial siderosis (SIS) is a rare and often unrecognized disorder of the central nervous system (CNS) characterized by progressive neuronal degeneration resulting from chronic subarachnoid bleeding. Hemoglobin accumulates in space where it metabolized to hemosiderin deposited subpial layer those parts CNS adjacent cerebrospinal fluid with predilection for inter alia cerebellum cranial nerves I, II VIII. Hemosiderin deposits lead damage, reactive gliosis, demyelination. Often...
Introduction: Percutaneous closure of patent foramen ovale (PFO) has become a widely used procedure in patients with suspected paradoxical embolism.Despite being generally safe and effective, the minimally invasive intervention been associated several serious complications such as air embolism, cardiac perforation, device embolization, thrombus formation puncture site problems.Unlike conventionally devices originally designed for atrial septum defects, novel Premere PFO Closure System...
Das seltene Krankheitsbild der Autoimmunpankreatitis hat eine vieldeutige Symptomatik, zu extrahepatische Cholestase, abdominelle Schmerzen sowie umschriebene oder generalisierte Pankreasveränderungen zählen. Fehldiagnosen sind deshalb häufig.
Background and Objectives: We aimed to analyze compare the outcomes of conventional ectropion surgery procedures with without concurrent bicanalicular nasolacrimal duct intubation identify if combination could serve as a novel surgical approach treat lower eyelid ectropion. Materials Methods: A retrospective review all patients who underwent correction for at Cantonal Hospital Aarau between January 2019 December 2020 was performed. Patient medical records were examined etiology, technique...