A5076408885- Neurotransmitter Receptor Influence on Behavior
- Obsessive-Compulsive Spectrum Disorders
- Autism Spectrum Disorder Research
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Treatment of Major Depression
- Schizophrenia research and treatment
- Epilepsy research and treatment
- Functional Brain Connectivity Studies
- Receptor Mechanisms and Signaling
- Diet and metabolism studies
- Memory and Neural Mechanisms
- Eating Disorders and Behaviors
- Transgenic Plants and Applications
- Veterinary Pharmacology and Anesthesia
- Attention Deficit Hyperactivity Disorder
- Cannabis and Cannabinoid Research
- Cutaneous Melanoma Detection and Management
- Genetic Mapping and Diversity in Plants and Animals
- Dermatological diseases and infestations
- Neuropeptides and Animal Physiology
- Genetic diversity and population structure
- Hypothalamic control of reproductive hormones
- Retinal Diseases and Treatments
- Neural and Behavioral Psychology Studies
Yale University
2019-2024
University of California, San Diego
2018-2023
University of Chicago
2015-2020
Natural Resources Canada
2017
Canadian Forest Service
2017
Universidad Católica Santo Domingo
2017
Medical College of Wisconsin
2009
Missense mutations in the cone opsins have been identified as a relatively common cause of red/green color vision defects, with most frequent mutation being substitution arginine for cysteine at position 203 (C203R). When corresponding is mutated rhodopsin, it disrupts proper folding pigment, causing severe, early onset retinitis pigmentosa. While C203R has associated loss function deficiency, not known what happens to cones expressing this mutant opsin. Here, we used high-resolution retinal...
Abstract The scaffold protein DLGAP1 is localized at the post-synaptic density (PSD) of glutamatergic neurons and a component supramolecular complexes organized by PSD95. Gain-of-function variants have been associated with obsessive-compulsive disorder (OCD), while haploinsufficient linked to autism spectrum (ASD) schizophrenia in human genetic studies. We tested male female Dlgap1 wild type (WT), heterozygous (HT), knockout (KO) mice battery behavioral tests: open field, dig, splash,...
Abstract BTB/POZ domain-containing 3 ( BTBD3 ) was identified as a potential risk gene in the first genome-wide association study of obsessive-compulsive disorder (OCD). is putative transcription factor implicated dendritic pruning developing primary sensory cortices. We assessed whether also regulates neural circuit formation within limbic cortico-striato-thalamo-cortical circuits and behaviors related to OCD mice. Behavioral phenotypes associated with that are measurable animals include...
Beliefs—attitudes toward some state of the environment—guide action selection and should be robust to variability but sensitive meaningful change. Beliefs about volatility (expectation change) are associated with paranoia in humans, brain regions responsible for beliefs remain unknown. The orbitofrontal cortex (OFC) is central adaptive behavior, whereas magnocellular mediodorsal thalamus (MDmc) essential arbitrating between perceptions policies. We assessed belief updating a three-choice...
Abstract Individuals with alcohol use disorder exhibit compulsive habitual behaviors that are thought to be, in part, a consequence of chronic and persistent alcohol. The endocannabinoid system plays critical role habit learning ethanol self‐administration, but the this neuromodulatory expression seeking is unknown. Here, we investigated established habits using contingency degradation male C57BL/6 mice. We found administration novel diacyl glycerol lipase inhibitor DO34, which decreases...
Protein Tyrosine Phosphatase receptor type D (PTPRD) is a member of the protein tyrosine phosphatase family that mediates cell adhesion and synaptic specification. Genetic studies have linked Ptprd to several neuropsychiatric phenotypes, including Restless Leg Syndrome (RLS), opioid abuse disorder, antipsychotic-induced weight gain. Genome-wide association (GWAS) either pediatric obsessive-compulsive traits, or Obsessive-Compulsive Disorder (OCD), identified loci near PTPRD as genome-wide...
Hybridization between species is known to greatly affect their genetic diversity and, therefore, evolution. Also, within species, there may be clusters which gene flow limited, impact natural selection. However, few studies have looked simultaneously at the influence of among-species and within-species flow. Here, we study hybridization Populus balsamifera trichocarpa on population structure adaptation in P. balsamifera. We did this by sampling a total 1517 individuals from across ranges...
Abstract Opioids have been used to manage pain for thousands of years, but they significant potential abuse. Prescription opioids, like oxycodone, are associated with 32% overdoses, that reached a total 75,673 deaths in 2021. A major challenge is maximizing their therapeutic while minimizing the negative side effects including opioid use disorder (OUD). The Ketogenic Diet (KD) has reported reduce and decrease severity alcohol disorder, yet its on oxycodone responses remain unknown. KD mice...
Serotonin-1B receptors (5-HT1BRs) modulate perseverative behaviors and prepulse inhibition (PPI) in humans mice. These inhibitory G-protein-coupled signal through a canonical pathway that is modulated by GSK-3β, noncanonical mediated the adaptor protein β-arrestin2 (Arrb2). Given development of biased ligands differentially affect versus signaling, we examined which signaling mediates 5-HT1BR agonist-induced locomotor perseveration PPI deficits, behavioral phenotypes observed both...
Metabotropic glutamate receptor 5 (mGlu5) plays an important role in excessive alcohol use and the mGlu5/Homer2/Erk2 signaling pathway has been implicated binge drinking. The mGlu5 negative allosteric modulator (NAM) 2-methyl-6-(phenylethynyl)pyridine hydrochloride (MPEP) shown to reduce drinking male mice, but less is known about its effect on female mice. Here, we sought determine whether sex differences exists effects of MPEP they relate changes signaling.
More effective treatments to reduce pathological alcohol drinking are needed. The glutamatergic system and the NMDA receptor (NMDAR), in particular, implicated behavioral molecular consequences of chronic use, making NMDAR a promising target for novel pharmacotherapeutics. Ethanol exposure upregulates Fyn, protein tyrosine kinase that indirectly modulates signaling by phosphorylating NR2B subunit. Src/Fyn inhibitor saracatinib (AZD0530) reduces ethanol self-administration enhances extinction...
Abstract Opioids have been used to manage pain for thousands of years, but they significant potential abuse. Prescription opioids, like oxycodone, are associated with 32% overdoses, that reached a total 75,673 deaths in 2021. A major challenge is maximizing their therapeutic while minimizing the negative side effects including opioid use disorder (OUD). The Ketogenic Diet (KD) has reported reduce and decrease severity alcohol disorder, yet its on oxycodone remain unknown. KD mice displayed...
Beliefs – attitudes toward some state of the environment guide action selection and should be robust to variability but sensitive meaningful change. about volatility (expectation change) are associated with paranoia in humans yet brain regions responsible for beliefs remain unknown. Orbitofrontal cortex (OFC) is central adaptive behavior whereas magnocellular mediodorsal thalamus (MDmc) essential arbitrating between perceptions policies. We assessed belief updating a three-choice...