A5085073316- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Memory and Neural Mechanisms
- Autism Spectrum Disorder Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Tryptophan and brain disorders
- Receptor Mechanisms and Signaling
- Obsessive-Compulsive Spectrum Disorders
- Neuroendocrine regulation and behavior
- Nerve injury and regeneration
- Treatment of Major Depression
- Substance Abuse Treatment and Outcomes
- HIV Research and Treatment
- Protein Degradation and Inhibitors
- Olfactory and Sensory Function Studies
- Cannabis and Cannabinoid Research
- Epigenetics and DNA Methylation
- Transgenic Plants and Applications
- Stress Responses and Cortisol
University of California, San Diego
2017-2019
University of Chicago
2017
Universidad Católica Santo Domingo
2017
Oregon Health & Science University
2011-2014
Abstract The scaffold protein DLGAP1 is localized at the post-synaptic density (PSD) of glutamatergic neurons and a component supramolecular complexes organized by PSD95. Gain-of-function variants have been associated with obsessive-compulsive disorder (OCD), while haploinsufficient linked to autism spectrum (ASD) schizophrenia in human genetic studies. We tested male female Dlgap1 wild type (WT), heterozygous (HT), knockout (KO) mice battery behavioral tests: open field, dig, splash,...
Background: Neurosteroids and other γ-aminobutyric acidA (GABAA) receptor–modulating compounds have been shown to affect ethanol intake, although their mechanism remains unclear. This study examined how patterns of 24-hour drinking in mice were altered with the synthetic GABAergic neurosteroid ganaxolone (GAN), an inhibitor synthesis (finasteride [FIN]), or a GABAA receptor agonist some selectivity at extrasynaptic receptors (gaboxadol HCL [THIP]). Methods: Male C57BL/6J had continuous...
Schizophrenia has been consistently characterized by abnormal patterns of gene down-regulation, increased restrictive chromatin assemblies, and reduced transcriptional activity. Histone methyltransferase (HMT) mRNA H3K9me2 levels are elevated in postmortem brain peripheral blood cells persons with schizophrenia. Moreover, this epigenomic state likely contributes to the disease, as HMT correlate clinical symptomatology. This manuscript sought establish potential therapeutic value inhibitor...