A5049962686- Schizophrenia research and treatment
- Epigenetics and DNA Methylation
- Tryptophan and brain disorders
- Genetics and Neurodevelopmental Disorders
- Bipolar Disorder and Treatment
- CRISPR and Genetic Engineering
- Electroconvulsive Therapy Studies
- Mental Health and Psychiatry
- Stress Responses and Cortisol
- Virus-based gene therapy research
- Histone Deacetylase Inhibitors Research
- Psychosomatic Disorders and Their Treatments
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- Mental Health Research Topics
- Treatment of Major Depression
- Autism Spectrum Disorder Research
- RNA modifications and cancer
- CAR-T cell therapy research
- HIV Research and Treatment
- Genomics and Chromatin Dynamics
- Mental Health Treatment and Access
- RNA Research and Splicing
- Chemical Synthesis and Analysis
- Neurogenesis and neuroplasticity mechanisms
University of Illinois Chicago
2015-2024
Jesse Brown VA Medical Center
2013-2023
Stanford University
2018-2022
California Institute for Regenerative Medicine
2018-2022
Ashland (United States)
2018
Neuropsychiatric Research Institute
2017
Psychiatric Medical Center
2013-2016
Children's Hospital of Philadelphia
2010-2015
Bexhill Hospital
2015
Alembic Pharmaceuticals (India)
2013
<h3>Background</h3> Reelin (RELN) is a glycoprotein secreted preferentially by cortical γ-aminobutyric acid-ergic (GABAergic) interneurons (layers I and II) that binds to integrin receptors located on dendritic spines of pyramidal neurons or GABAergic layers III through V expressing the disabled-1 gene product (DAB1), cytosolic adaptor protein mediates RELN action. To replicate earlier findings glutamic acid decarboxylase (GAD)<sub>67</sub>, but not DAB1 expression, are down-regulated in...
Postmortem prefrontal cortices (PFC) (Brodmann’s areas 10 and 46), temporal area 22), hippocampi, caudate nuclei, cerebella of schizophrenia patients their matched nonpsychiatric subjects were compared for reelin ( RELN ) mRNA (RELN) protein content. In all the brain studied, its significantly reduced (≈50%) in with schizophrenia; this decrease was similar affected by undifferentiated or paranoid schizophrenia. To exclude possible artifacts caused postmortem degradation, we measured mRNAs...
Reelin mRNA and protein levels are reduced by ≈50% in various cortical structures of postmortem brain from patients diagnosed with schizophrenia or bipolar illness psychosis. In addition, the encoding methylating enzyme, DNA methyltransferase 1, is up-regulated same neurons that coexpress reelin glutamic acid decarboxylase 67. We have analyzed extent pattern methylation within CpG island promoter genomic isolated cortices nonpsychiatric subjects. Ten (The Stanley Foundation Neuropathology...
Reelin and glutamic acid decarboxylase (GAD) 67 expressed by cortical γ-aminobutyric acid-ergic interneurons are down-regulated in schizophrenia. Because epidemiological studies of schizophrenia fail to support candidate gene haploinsufficiency Mendelian origin, we hypothesize that epigenetic mechanisms (i.e., cytosine hypermethylation CpG islands present the promoter these genes) may be responsible for this down-regulation. Protracted l -methionine (6.6 mmol/kg 15 days, twice a day)...
The polygenic nature of complex psychiatric disorders suggests a common pathway that may be involved in the down-regulation multiple genes through an epigenetic mechanism. To investigate role methylation down-regulating expression mRNAs associated with schizophrenia phenotype, we have adopted cell-culture model amenable to this line investigation. We administered methionine (2 mM) primary cultures cortical neurons prepared from embryonic day 16 mice and show treatment down-regulated reelin...
Associations between a pro-inflammatory state and schizophrenia have been one of the more enduring findings psychiatry, with various lines evidence suggesting compelling role for IL-6 in underlying pathogenesis schizophrenia.In this study, we examined mRNA levels by real-time RT-PCR from fresh extracted peripheral blood mononuclear cells (PBMC) normal controls participants schizophrenia.We found that PBMC levels, absence any other information, reliably discriminated diagnosis controls....
The conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) is a key step in DNA demethylation that mediated by ten-eleven translocation (TET) enzymes, which require ascorbate/vitamin C. Here, we report the 5hmC landscape normal hematopoiesis and identify cell type-specific profiles associated with active transcription chromatin accessibility hematopoietic regulators. We utilized CRISPR/Cas9 model TET2 loss-of-function mutations primary human stem progenitor cells (HSPC)....
The relationship between CSF neurotensin concentrations and measures of psychopathology in patients with schizophrenia or schizoaffective disorder was examined before after treatment antipsychotic drugs.CSF were measured 42 drug-free disorder. For 18 these patients, measure again 4 weeks treatment.Significantly higher levels pretreatment observed the lowest concentrations. Furthermore, improvements overall and, particularly, negative symptoms correlated increases during treatment.These...