A5038492593- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Adipose Tissue and Metabolism
- Genetic Mapping and Diversity in Plants and Animals
- Receptor Mechanisms and Signaling
- Peroxisome Proliferator-Activated Receptors
- Memory and Neural Mechanisms
- Stress Responses and Cortisol
- Biochemical Analysis and Sensing Techniques
- Alcohol Consumption and Health Effects
- Neuroendocrine regulation and behavior
- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Alcoholism and Thiamine Deficiency
- Metabolism and Genetic Disorders
- Diet and metabolism studies
- Zebrafish Biomedical Research Applications
- Pharmaceutical studies and practices
- Neuropeptides and Animal Physiology
- Electroconvulsive Therapy Studies
- Sleep and Wakefulness Research
- Tryptophan and brain disorders
- Schizophrenia research and treatment
- Genetic and phenotypic traits in livestock
- Amino Acid Enzymes and Metabolism
Oregon Health & Science University
2015-2024
VA Portland Health Care System
2016-2024
Portland VA Medical Center
2009-2020
University of California, San Diego
2017
Alcohol Research Group
2001-2016
Veterans Health Administration
1996-2013
University College Cork
2010
Indiana University – Purdue University Indianapolis
2001-2010
McLean Hospital
2010
Harvard University
2010
Strains of mice that show characteristic patterns behavior are critical for research in neurobehavioral genetics. Possible confounding influences the laboratory environment were studied several inbred strains and one null mutant by simultaneous testing three laboratories on a battery six behaviors. Apparatus, test protocols, many environmental variables rigorously equated. differed markedly all behaviors, despite standardization, there systematic differences across labs. For some tests,...
Recently, we described a simple procedure, Drinking in the Dark (DID), which C57BL/6J mice self-administer ethanol to blood concentration (BEC) above 1 mg/ml. The test consists of replacing water with 20% home cage for 4 h early during dark phase light/dark cycle. Three experiments were conducted explore this high drinking model further. In experiment 1, microanalysis behavior showed that pattern was different from routine intake. 2, impaired performance on accelerating rotarod and balance...
Treatment options for alcohol use disorders (AUDs) have minimally advanced since 2004, while the annual deaths and economic toll increased alarmingly. Phosphodiesterase type 4 (PDE4) is associated with nicotine dependence. PDE4 inhibitors were identified as a potential AUD treatment using bioinformatics approach. We prioritized newer inhibitor, apremilast, ideal repurposing (i.e., FDA approved psoriasis, low incidence of adverse events, excellent safety profile) tested it multiple animal...
There is increasing interest in determining the extent to which multiple characters related drug sensitivity are influenced by common genes. The principal method for testing existence of such genetic correlations has been examination pairs mouse or rat lines selectively bred resistance a single behavioral effect drug. When pair selected found differ significantly on some trait other than one they were selected, it commonly concluded that significant correlation between traits exists,...
The genomic map locations of specific genes controlling behaviors can be identified by studying a panel recombinant inbred (RI) mouse strains. progenitor C57BL/6J (B6) and DBA/2J (D2) strains, 19 the BXD RI strains derived from an F2 cross these progenitors, were tested for 3% 10% ethanol (EtOH) intake. test sequence began with two‐bottle free choice between tap water unsweetened ethanol, ended saccharin‐sweetened ethanol. Saccharin preference was also measured. Correlational analyses...
If we conduct the same experiment in two laboratories or repeat a classical study many years later, will obtain results? Recent research with mice neural and behavioral genetics yielded different results for certain phenotypes, these findings suggested to some researchers that behavior may be too unstable fine-scale genetic analysis. Here expand range of data on this question additional and, first time field, formally compare recent experiments conducted 30–50 ago. For ethanol preference...
Alcohol dependence (alcoholism) is accompanied by evidence of tolerance, withdrawal (physiological dependence), or compulsive behavior related to alcohol use. Studies strain and individual differences using animal models for acute physiological liability are useful means identify potential genetic determinants in humans. Behavioral quantitative trait analyses were conducted high risk versus resistance dependence. Using a two-step mapping strategy, loci on mouse chromosomes 1, 4, 11 mapped...
Studies in rodents have determined that intermittent exposure to alcohol vapor can increase subsequent ethanol self-administration, measured with operant and 2-bottle choice procedures. Two key procedural factors demonstrating increased intake are the establishment of stable self-administration before number bouts exposure. The present studies provide additional behavioral validation initial pharmacological this withdrawal-associated drinking procedure.Studies at 2 different sites (Portland...