A5008609077- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Adipose Tissue and Metabolism
- Genetic Mapping and Diversity in Plants and Animals
- Stress Responses and Cortisol
- Memory and Neural Mechanisms
- Biochemical Analysis and Sensing Techniques
- Zebrafish Biomedical Research Applications
- Peroxisome Proliferator-Activated Receptors
- Neuroendocrine regulation and behavior
- Cannabis and Cannabinoid Research
- Nicotinic Acetylcholine Receptors Study
- Alcohol Consumption and Health Effects
- Pharmacological Effects and Assays
- Tryptophan and brain disorders
- Neuropeptides and Animal Physiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Genetic and phenotypic traits in livestock
- Regulation of Appetite and Obesity
- Forensic Toxicology and Drug Analysis
- Lipid metabolism and biosynthesis
- Behavioral and Psychological Studies
- Genetics and Physical Performance
- GABA and Rice Research
VA Portland Health Care System
2016-2025
Oregon Health & Science University
2015-2024
Alcohol Research Group
2004-2024
Vollum Institute
2008-2022
Case Western Reserve University
2022
University of Colorado Anschutz Medical Campus
2022
New York University Abu Dhabi
2022
Portland VA Medical Center
2006-2015
Weatherford College
2014
United States Department of Veterans Affairs
1990-2014
Locomotor activity is a polygenic trait that varies widely among inbred strains of mice (Flint et al., 1995). To characterize the role D2 dopamine receptors in locomotion, we generated F 2 hybrid (129/Sv × C57BL/6) receptor (D2R)-deficient by gene targeting and investigated contribution genetic background to open-field rotarod performance. Horizontal D2R−/− was approximately half drug-naive, strain-matched controls but significantly greater than haloperidol-treated controls, which were...
There is increasing interest in determining the extent to which multiple characters related drug sensitivity are influenced by common genes. The principal method for testing existence of such genetic correlations has been examination pairs mouse or rat lines selectively bred resistance a single behavioral effect drug. When pair selected found differ significantly on some trait other than one they were selected, it commonly concluded that significant correlation between traits exists,...
The genomic map locations of specific genes controlling behaviors can be identified by studying a panel recombinant inbred (RI) mouse strains. progenitor C57BL/6J (B6) and DBA/2J (D2) strains, 19 the BXD RI strains derived from an F2 cross these progenitors, were tested for 3% 10% ethanol (EtOH) intake. test sequence began with two‐bottle free choice between tap water unsweetened ethanol, ended saccharin‐sweetened ethanol. Saccharin preference was also measured. Correlational analyses...
Investigations of ethanol's (EtOH's) complex response profile, including locomotor and other effects, are likely to lead a more in‐depth understanding the constituents alcohol addiction. Locomotor activity responses acute repeated EtOH (2 g/kg, ip) exposures were measured in BXD recombinant inbred (RI) mice their C57BL/6J (B6) DBA/2J (D2) progenitors. Both change initial with treatments strain‐dependent. The coefficient genetic determination was 0.38–0.49 for EtOH, 0.29 response. Changes...
Abstract Peak bone mass is a major determinant of risk osteoporotic fracture. Family and twin studies have found strong genetic component to the determination mineral density (BMD). However, BMD complex trait whose expression confounded by environmental influences polygenic inheritance. The number, locations, effects individual genes contributing natural variation in this are all unknown. Experimental animal models provide means circumvent complicating factors, development dense maps based...
Common features shared by addictive drugs have been difficult to identify. One ubiquitous effect of these is psychomotor stimulation. Further, repeated exposure commonly results in sensitization drug stimulant effects. This study evaluates from several classes C57BL/6J and DBA/2J inbred strain mice. mice showed sensitized responses ethanol methamphetamine, whereas developed morphine methamphetamine. Strain susceptibilities ethanol- morphine-induced closely paralleled their sensitivities the...