A5030841717- Gut microbiota and health
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Stress Responses and Cortisol
- Tryptophan and brain disorders
- Bariatric Surgery and Outcomes
- Gastrointestinal motility and disorders
- Clinical Nutrition and Gastroenterology
- Eating Disorders and Behaviors
- HIV/AIDS Research and Interventions
- Vitamin C and Antioxidants Research
- Ocular Infections and Treatments
- Optimism, Hope, and Well-being
- Inflammatory Bowel Disease
- Dermatology and Skin Diseases
- Obsessive-Compulsive Spectrum Disorders
- Metabolism, Diabetes, and Cancer
- HIV-related health complications and treatments
- Colorectal Cancer Screening and Detection
- Autism Spectrum Disorder Research
- Neuroendocrine regulation and behavior
- Clostridium difficile and Clostridium perfringens research
- Ocular Diseases and Behçet’s Syndrome
- Pancreatic and Hepatic Oncology Research
- Adipose Tissue and Metabolism
University of California, Los Angeles
2018-2024
VA Greater Los Angeles Healthcare System
2022
University of California, San Diego
2018
University of Chicago
2015
Background Alterations in brain‐gut‐microbiome interactions have been implicated as an important factor obesity. This study aimed to explore the relationship between food addiction (FA) and axis, using a multi‐omics approach involving microbiome data, metabolomics, brain imaging. Methods Brain magnetic resonance imaging was obtained 105 females. FA defined by Yale Food Addiction Scale. Fecal samples were collected for sequencing metabolomics. Statistical analysis done multivariate analyses...
Background: High protein calorie restriction diets have shown clinical efficacy for obesity, but the mechanisms are not fully known. The intestinal microbiome is a mediator of obesity and preclinical data support an effect high diet (HPD) on gut there few studies in humans. Methods: To address this, we conducted dietary intervention trial 80 overweight obese subjects who were randomized to calorie-restricted (30% intake) or normal (NPD) (15%) 8 weeks. Baseline intake patterns assessed by...
Abstract The presence of advanced fibrosis is an important measure the severity chronic liver disease. Prior works that have examined gut microbiome as a novel biomarker for only patients with nonalcoholic fatty Therefore, our goal was to examine across varying etiologies disease create predictive model based upon microbial signature. Stool samples were obtained from (n = 50) undergoing FibroScan (ultrasound elastography) at VA Greater Los Angeles Healthcare System. Healthy control 25) also...
Bariatric surgery remains a potent therapy for nonalcoholic fatty liver disease (NAFLD), but its inherent risk and eligibility requirement limit adoption. Therefore, understanding how bariatric improves NAFLD is paramount to developing novel therapeutics. Here, we show that the microbiome changes induced by sleeve gastrectomy (SG) reduce glucose-dependent insulinotropic polypeptide (GIP) signaling confer resistance against diet-induced obesity (DIO) NAFLD. We examined cohort of NALFD...
Although perceived stress (PS) has been associated with symptomatic flares in inflammatory bowel disease, clinical and physiological measures flare are not known. The aim of this study was to identify factors ulcerative colitis (UC) subjects, their relationship flare.Patients UC remission (Simple Colitis Clinical Activity Index [SCCAI] score <5) underwent behavioral assessments, morning salivary cortisol measurements, autonomic nervous system activity testing (heart rate variability,...
Pancreatic ductal adenocarcinoma (PDAC)'s growing incidence has been linked to the rise in obesity and type 2 diabetes mellitus. In previous work, we have shown that metformin can prevent increased of PDAC a Kras
Abstract Background Stress reactivity (SR) is associated with increased risk of flares in ulcerative colitis (UC) patients. Because both preclinical and clinical data support that stress can influence gut microbiome composition function, we investigated whether profiles SR exist UC. Methods Ninety-one UC subjects biochemical remission were classified into high low groups by questionnaires. Baseline longitudinal characterization the intestinal was performed 16S rRNA gene sequencing fecal...
Background: The microbiome has been shown in pre-clinical and epidemiological studies to be important both the development treatment of obesity metabolic associated fatty liver disease (MAFLD). However, few have examined role clinical response calorie restriction. To explore this area, we performed a prospective study examining association intestinal with weight loss change hepatic steatosis on calorie-restricted diet. Methods: A dietary intervention 80 overweight obese participants was at...
Background: Studies of the ocular microbiome have used a variety sampling techniques, but no study has directly compared different methods applied to same eyes one another or reference standard corneal epithelial biopsy. We addressed this lack by comparing from three conjunctival swabs with those Methods: Twelve (11 patients) were swabbed calcium alginate swab, cotton-tipped applicator, and Weck-Cel cellulose sponge before biopsy (48 samples). then performed 16S rRNA gene sequencing...
Abstract Background The microbiota plays an important role in HIV pathogenesis humans. Microbiota can impact health through several pathways such as increasing inflammation the gut, metabolites of bacterial origin, and microbial translocation from gut to periphery which contributes systemic chronic immune activation development AIDS. Unlike HIV-infected humans, SIV-infected vervet monkeys do not experience dysfunction, translocation, progress immunodeficiency. Here, we provide first reported...
Objective The study objective was to compare the microbial composition of patients with dermatomyositis (DM) and healthy controls (HCs) determine whether alterations are associated clinical manifestations DM. Methods 16S ribosomal RNA gene sequencing performed on fecal samples from DM HCs. Microbial diversity were compared between subjects HCs in association several DM‐specific variables, including myositis‐specific autoantibodies (MSAs). Differentially abundant taxa genes characteristics...
Rodents develop activity-based anorexia (ABA) when exposed to a restricted feeding schedule and allowed free access running wheel. These conditions lead life-threatening reduction in body weight. However, rodents only one of these ultimately adapt re-establish normal Although increased coupled with voluntary food intake appear paradoxical under ABA conditions, behavior is observed across numerous mammalian species. The paradigm provides an animal model for nervosa (AN), eating disorder...
Hepatoma Research is an open access journal and focuses on all topics related to hepatoma. The following articles are especially welcome: pathogenesis, clinical examination early diagnosis of hepatoma, complications their preventions treatments, etc.
Introduction Metabolic dysfunction-associated steatotic liver disease (MASLD) affects nearly 25% of the population and is leading cause for liver-related mortality. Bariatric surgery a well-known treatment MASLD obesity. Understanding fundamental mechanisms by which bariatric can alter lead to new avenues therapy research. Previous studies have identified microbiome’s role in inflammatory immune cell populations. The host innate system modulates hepatic inflammation fibrosis, thus...
Abstract Early life trauma and obesogenic diet effects of feeding control. Consumption a Western-like high-saturated fat (WD, 42% kcal from fat) during adolescence in combination with (2) Exposure to early-life psychosocial stress leads (3) changes brain neurocircuitry metabolic dysregulation. These alterations lead (4) susceptibility, (5) emotional dysregulation, (6) obesity. Dysregulation control obesity increased hedonic engages individuals cycle aberrant behaviors. Background Childhood...
Rodents develop activity-based anorexia (ABA) when exposed to a restricted feeding schedule and allowed free access running wheel.These conditions lead life-threatening reduction in body weight.However, rodents only one of these ultimately adapt re-establish normal weight.Although increased coupled with voluntary food intake appear paradoxical under ABA conditions, behavior is observed across numerous mammalian species.The paradigm provides an animal model for nervosa (AN), eating disorder...