A5096198954- Diet and metabolism studies
- Stress Responses and Cortisol
- Liver Disease Diagnosis and Treatment
- Listeria monocytogenes in Food Safety
- Tryptophan and brain disorders
- Liver Disease and Transplantation
- Diabetes and associated disorders
- Systemic Lupus Erythematosus Research
- Receptor Mechanisms and Signaling
- Mathematical Biology Tumor Growth
- Plant Pathogenic Bacteria Studies
- Resilience and Mental Health
- Drug-Induced Hepatotoxicity and Protection
- Gut microbiota and health
University of California, Los Angeles
2024
Introduction Metabolic dysfunction-associated steatotic liver disease (MASLD) affects nearly 25% of the population and is leading cause for liver-related mortality. Bariatric surgery a well-known treatment MASLD obesity. Understanding fundamental mechanisms by which bariatric can alter lead to new avenues therapy research. Previous studies have identified microbiome’s role in inflammatory immune cell populations. The host innate system modulates hepatic inflammation fibrosis, thus...
Abstract Altered serotonin signaling is a well-established contributor to depression, with the transporter gene (SERT) playing critical role in regulating reuptake. Mice lacking SERT (SERT -/-) serve as robust model for exhibiting significant depressive-like behaviors compared littermate wild-type +/+) controls. In this study, we aimed determine relationship between gut microbiota composition and depressive -/- mice. Behavioral assays, including Forced Swim Test (FST) Tail Suspension (TST),...
Metabolic dysfunction-associated steatotic liver disease (MASLD), driven by obesity and metabolic syndrome, is increasingly prevalent a significant contributor to fibrosis, cirrhosis, liver-related mortality. Emerging research implicates the gut microbiome as critical player in MASLD progression, yet specific microbial drivers remain poorly understood. Here, we explore role of Prevotella copri (P. copri) progression through both human patient cohorts mouse model diet-induced obesity. Using...