There are currently no international guidelines regarding treatment in the early rehabilitation phase for persons with severe traumatic brain injury (TBI), and only a few studies have investigated effect of integrating into acute TBI care. The aim study was to evaluate whether continuous chain that begins could improve functional outcome patients, compared broken starts sub-acute TBI. A total 61 surviving patients were included quasi-experimental conducted at Level I trauma center Eastern...

Primary objectives: To examine self-reported post-concussion symptoms from 3–12 months post-injury in adults with traumatic brain injury (TBI) and to identify predictors of these symptoms.Methods procedures: A 1-year prospective study Eastern Norway including 115 persons (16–55 years), mild, moderate severe TBI. The Rivermead Post Concussion Symptoms Questionnaire (RPQ) Hospital Anxiety Depression Scale (HADS) were administered. Magnetic resonance imaging (MRI) was performed at 12...

Outcome studies on traumatic brain injury (TBI) have shown that functional status can be predicted by demographic, severity, and trauma-related factors. Concurrent cognitive functions as one of the determinants outcome is less documented. This study evaluated effects concurrent neuropsychological measures 1 year after injury. Neuropsychological data, employment status, self-reported fatigue, Glasgow Scale-Extended (GOSE) were collected from 115 persons with TBI (ranging mild to severe) at 3...

AbstractPurpose. The purpose of this study was to assess disability and the physical mental health status 1 year after traumatic brain injury (TBI), using International Classification Functioning, Disability Health (ICF) as a conceptual model for understanding TBI disability.Methods. A prospective 85 patients with moderate-to-severe (aged 16–55 years) due occurring from May 2005 2007 hospitalised at Trauma Referral Centre in Eastern Norway were included. severity structural damage overall...

Summary. The genetic diversity in the first domain exon of a bovine class II DRB gene was investigated by PCR amplification and DNA sequencing. Genomic samples representing 14 different haplotypes, defined RFLP analysis, were used. analysis revealed an extensive polymorphism alleles at single locus, designated DRB3, identified. Multiple amino acid substitutions found all pairwise comparisons alleles; 5 to 21 83 positions compared. level cattle matches one previously DRB1 locus man....

<i>Background:</i> The aim of this prospective, population-based study is to present the incidence hospital-treated traumatic brain injury (TBI) in Oslo, Norway, and describe severity injuries outcome patients’ acute medical care. <i>Methods:</i> Data were obtained from hospital admission registers records May 2005 2006. initial TBI was measured by Glasgow Coma Scale. region urban with a population 534,129. <i>Results:</i> 445 patients identified represent...

<b><i>Aims:</i></b> The aims of this study were to assess the incidence hospital-admitted severe traumatic brain injury (TBI) in adult population Norway, and determine whether there differences epidemiological characteristics TBI between rural urban regions. <b><i>Methods:</i></b> A prospective population-based on adults with admitted Norwegian Trauma Referral Centres during 2-year period (2009–2010). electronic patient register was searched...

Objectives: To assess burden in the caregivers of patients with severe traumatic brain injury (TBI) 1 year postinjury, related to caregiver's demographic data and social network, patient's data, severity, functional status. Design: Prospective national multicenter study. Self-report from caregivers, patient collected cohort on TBI. Participants: 92 caregivers. Main outcome measure: The Caregiver Burden Scale (CBS). Results: Total caregiver was reported high 16% moderate 34%. mean total index...

Objective: To investigate associations between disability and employment 1 year after traumatic brain injury (TBI) using the International Classification of Functioning, Disability Health (ICF) as a conceptual model.Design methods: A prospective study including 93 patients with moderate-to-severe TBI (aged 16–55 year). components ICF model (impairments, activity limitations participation restrictions) personal factors (age, gender, pre-injury status) were used independent variables. The...

Aims To describe health-related quality of life (HRQL) 2 years after moderate-to-severe traumatic brain injury (TBI) and to assess predictors HRQL. Materials methods A prospective cohort study 91 patients, aged 16–55 years, admitted with TBI a trauma referral centre between 2005 2007, follow-up at 1 years. Mean age was 31.1 (SD = 11.3) 77% were men. Injury severity evaluated by the Glasgow Coma Scale (GCS), head CT scan (using modified Marshall Classification), Severity Score (ISS)...

Abstract Objectives: The present study explored the level of self-and informant reported executive functioning in daily living using Behavior Rating Inventory Executive Function-Adult Version (BRIEF-A) a large sample comprising healthy adults and patient cohorts with neurological neuropsychiatric disorders. relationship to neuropsychological test performance self-reported emotional distress was explored, as well applicability U.S. normative data. Methods: Scores on self- BRIEF-A are...

Aims: Based on important predictors, global functional outcome after traumatic brain injury (TBI) may vary significantly over time. This study sought to: (1) describe changes in the Glasgow Outcome Scale-Extended (GOSE) score survivors of moderate to severe TBI, (2) examine longitudinal GOSE trajectories up 10 years injury, and (3) investigate predictors these based socio-demographic characteristics. Methods: Socio-demographic characteristics 97 TBI aged 16-55 were recorded at baseline. was...

To estimate the incidence of olfactory dysfunction across traumatic brain injury (TBI) severity and decision-making deficits with regard to intracranial lesions' location laterality.A 1-year prospective study including 115 participants (16-55 years) mild, moderate, severe TBI. The Brief Smell Identification Test was used 3 months postinjury a follow-up testing at 1 year. Iowa Gambling Task (IGT) tasks Delis-Kaplan Executive Function System were administered 3-months postinjury. MRI performed...

Objective To describe the self‐perceived health care needs of patients with moderate‐to‐severe traumatic brain injury (TBI) and to assess impact functional level at 1 year after on patients' unmet 5‐year follow‐up. Design A prospective follow‐up study. Setting Clinical research. Participants total 93 participated in Methods We registered demographic injury‐related data time admission scores for Disability Rating Scale, Glasgow Outcome Scale‐Extended, Short Form 36 subscales physical...

Primary objectives: To examine trajectories of employment probability and stability over the first 5 years after traumatic brain injury (TBI) by using multi-level modelling multinomial logistic regressions.

(1) To examine the impact of demographic and acute injury-related variables on functional recovery life satisfaction after severe traumatic brain injury (sTBI) (2) to test whether postinjury functioning, postconcussive symptoms, emotional state, improvement are related satisfaction.Prospective national multicenter study.Level 1 trauma centers in Norway.163 adults with sTBI.Functional between 3 12 months measured Glasgow Outcome Scale Extended, Rivermead Postconcussion Symptoms Questionnaire,...

The aim of this study is to estimate the long-term cost-effectiveness two different rehabilitation trajectories after severe traumatic brain injury (sTBI). A decision tree model compared hospitalization costs, health effects, and incremental ratios (ICER) a continuous chain versus broken rehabilitation. expected costs were estimated by reimbursement system using diagnosis-related group based on point estimates Disability Rating Scale (DRS); effects measured means area under curve (AUC)....

Objectives: To determine the rates of cognitive impairment 1 year after severe traumatic brain injury (TBI) and to examine influence demographic, severity, rehabilitation, subacute functional outcomes on TBI. Setting: National multicenter cohort study over 2 years. Participants: Patients (N = 105), aged 16 years or older, with Glasgow Coma Scale score 3 8 Galveston Orientation Amnesia Test more than 75. Main Measures : Neuropsychological tests representing domains Executive Functions,...

Background Bardet-Biedl syndrome (BBS) is a rare disorder involving complex combination of eye and kidney diseases, obesity learning difficulties. To better understand the roles family caregivers, this study sought to explore parents' experiences supporting adult children with BBS.

Abstract Background Bardet–Biedl syndrome (BBS) is a rare nonmotile ciliopathy characterized by retinal dystrophy, polydactyly, obesity, genital anomalies, renal dysfunction, and learning difficulties. The objectives were to describe the retinal, oral, metabolic characteristics relevant adults with BBS as well prevalence of genetic variants. Methods A cross-sectional study 30 (15 males, 15 females, mean age 39.8 ± 13.6 years) was recruited from single centre for disorders in Norway....

Summary. DQα, DQß, DRα and DRß class II genes of the bovine major histocompatibility complex (MHC) were investigated by Southern blot hybridizations using human probes. Hybridizations these probes to genomic DNA, digested with Pvull or Taql, revealed extensive restriction fragment length polymorphisms (RFLPs). The interpreted genetically analysing a family material, comprising five sires, 48 dams 50 offspring, population sample 197 breeding bulls. analysis resolved 20 17 5 25 RFLP types....

To determine the prevalence of depressive symptoms among individuals with traumatic brain injury (TBI) and to identify predictors psychological distress.A longitudinal study assessments at 3 months, 1 year 5 years after injury.A total 118 (29% females; mean age 32.5; range 16-55 years) mild-to-severe TBI who were hospitalized in Trauma Referral Centre from 2005 2007.Self-report using Hospital Anxiety- Depression Scale, Symptom Checklist 90-Revised Fatigue Severity Scale. Injury severity,...

To describe employment outcomes and assess the impact of personal environmental factors on 2 years after moderate-to-severe traumatic brain injury.A prospective cohort 100 patients with injury, aged 16-55 years, hospitalized in a Trauma Referral Centre during period 2005-2007 followed up at 1 post-injury.Variables interest were divided into factors. Personal include socio-demographics (age, gender, education, work demands, marital status child-care). Environmental included social (support by...

To examine trajectories of employment probability up to 10 years following moderate-to-severe traumatic brain injury (TBI) and identify significant predictors from baseline socio-demographic characteristics.

Identifying patients at risk of poor outcome after mild traumatic brain injury (MTBI) is essential to aid prognostics and treatment. Diffuse axonal (DAI) may be the primary pathologic feature MTBI but normally not detectable by conventional imaging technology. This lack sensitivity clinical techniques has impeded a pathophysiologic understanding long-term cognitive emotional consequences MTBI, which often remain unnoticed are attributed factors other than injury. Diffusion tensor (DTI)...