A5066863106- Extracellular vesicles in disease
- Salivary Gland Disorders and Functions
- Systemic Sclerosis and Related Diseases
- Ocular Surface and Contact Lens
- Advanced biosensing and bioanalysis techniques
- RNA modifications and cancer
- RNA Interference and Gene Delivery
- Congenital heart defects research
- Inflammatory Biomarkers in Disease Prognosis
- Aquaculture Nutrition and Growth
- MicroRNA in disease regulation
- Pluripotent Stem Cells Research
- Systemic Lupus Erythematosus Research
- Plant Pathogens and Fungal Diseases
- Spectroscopy Techniques in Biomedical and Chemical Research
- Cardiovascular Disease and Adiposity
- Tissue Engineering and Regenerative Medicine
- Reproductive biology and impacts on aquatic species
- Epigenetics and DNA Methylation
- Cell Adhesion Molecules Research
- Inflammasome and immune disorders
- Venous Thromboembolism Diagnosis and Management
- Cancer, Hypoxia, and Metabolism
- Gold and Silver Nanoparticles Synthesis and Applications
- Lipid Membrane Structure and Behavior
UiT The Arctic University of Norway
2023-2024
University of Oslo
2017-2020
University of Algarve
2012-2016
In-Q-Tel
2012
National University of San Luis
2000
Consejo Nacional de Investigaciones Científicas y Técnicas
2000
There is a long-lasting need for non-invasive, more accurate diagnostic techniques when evaluating primary Sjögren's syndrome (pSS) patients. Incorporation of additional diagnostics involving screening disease-specific biomarkers in biological fluid promising concept that requires further investigation. In the current study we aimed to explore novel disease saliva and tears from pSS patients.Liquid chromatography-mass spectrometry (LC-MS) was performed on stimulated whole 27 patients 32...
Extracellular vesicles (EVs) are a heterogeneous population of biological particles released by cells. They represent an attractive source potential biomarkers for early detection diseases such as cancer. However, it is critical that sufficient amounts EVs can be isolated and purified in robust reproducible manner. Several isolation methods seem to produce distinct populations exist, making data comparability difficult. While some induce cellular stress may affect both the quantity function...
Mononuclear cell infiltration of exocrine glands, production Ro/SSA and La/SSB autoantibodies, along with oral ocular dryness, are characteristic features primary Sjögren's syndrome (pSS). Non-SS sicca subjects, an underexplored group in relation to pSS, display similar symptoms, possible mild signs inflammation their salivary yet no serological detection autoantibody production. In this study, we investigated inflammatory manifestations the gland tissue, tear fluid saliva non-SS as compared...
This study focuses on the effects of triclosan (TCS), a ubiquitous antimicrobial agent and aquatic contaminant, thyroid adult zebrafish. The morphology was modified after short term (21 days) dietary exposure zebrafish to TCS (100 μg g−1 fish per day). Hyperplasia tissue observed in treated zebrafish, they had significantly (p < 0.01) more follicles, 0.05) bigger follicles significant reduction 0.001) thyrocyte height relative control fish, which is indicative inactivation. Analysis hormone...
Extracellular vesicles (EVs), are important for intercellular communication in both physiological and pathological processes. To explore the potential of cancer derived EVs as disease biomarkers diagnosis, monitoring, treatment decision, it is necessary to thoroughly characterize their biomolecular content. The aim study was compare protein content from three different cell lines search a specific molecular signature, with emphasis on proteins related carcinogenic process. Oral squamous...
The transcriptional regulator CITED2 is essential for heart development. Here, we investigated the role of in specification cardiac cell fate from mouse embryonic stem cells (ESC). overexpression undifferentiated ESC was sufficient to promote emergence upon differentiation. Conversely, depletion Cited2 at onset differentiation resulted a decline ability generate cells. Moreover, loss expression impairs early mesoderm markers and cardiogenic transcription factors (Isl1, Gata4, Tbx5). defects...
Extracellular vesicles (EVs) released from cells attract interest for their possible role in health and diseases. The detection characterization of EVs is challenging due to the lack specialized methodologies. Raman spectroscopy, however, has been suggested as a novel approach biochemical analysis EVs. To extract information spectra, deep learning architecture explored versatile variant autoencoders. proposed considers frequency range separately intensity spectra. This enables model adapt...
Nanoscale carriers such as liposomes and extracellular vesicles (EVs) are readily being explored for personalized medicine or disease prediction diagnostics, respectively. Owing to their small size, nanocarriers can undergo endocytosis exocytosis, providing means either transport cargo the cells (liposomes) serve a biomarker (EVs). When looking at current analysis methods, there is growing need detailed characterization of content composition in natural state aqueous media. This be achieved...
Table S5. Upregulated proteins in EVs isolated from whole saliva of non-SS subjects vs. pSS patients. (PDF 206 kb)
Table S6. Upregulated proteins in EVs isolated from whole saliva of controls vs. pSS patients. (PDF 211 kb)