A5033862913- Mitochondrial Function and Pathology
- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Treatment of Major Depression
- Tryptophan and brain disorders
- Congenital heart defects research
- Bipolar Disorder and Treatment
- Electroconvulsive Therapy Studies
- COVID-19 and Mental Health
- Functional Brain Connectivity Studies
- Transcranial Magnetic Stimulation Studies
- Gut microbiota and health
- Cancer-related gene regulation
- Computational Drug Discovery Methods
- Stress Responses and Cortisol
- Psychedelics and Drug Studies
- Genomic variations and chromosomal abnormalities
- Parkinson's Disease and Spinal Disorders
- Cholinesterase and Neurodegenerative Diseases
- Nutritional Studies and Diet
- RNA modifications and cancer
- Healthcare Decision-Making and Restraints
- Pharmacological Receptor Mechanisms and Effects
- Restless Legs Syndrome Research
- Healthcare during COVID-19 Pandemic
Unidade Hospitalar de Bragança
2023
Centro de Medicina de Reabilitacao do Alcoitão
2021-2022
Lusíada University of Lisbon
2021
Hospital da Luz
2020
Hospital das Forças Armadas
2019
Hospital de Santa Maria
2019
University of Algarve
2010-2018
University of Warwick
2009-2011
University Hospital Coventry
2010
Institute for Biotechnology and Bioengineering
2009
Oxidative phosphorylation (OXPHOS), the intracellular process that generates majority of ATP a cell through electron-transfer chain, is highly dependent on proteins encoded by mitochondrial genome (mtDNA). MtDNA replication regulated nuclear-encoded transcription factor A (TFAM) and mitochondrial-specific DNA polymerase gamma, which consists catalytic (POLG) an accessory (POLG2) subunit. Differentiation pluripotent embryonic stem cells (ESCs) into specific types requires expansion discrete...
As human embryonic stem cells (hESCs) undergo differentiation, they express genes characteristic of the lineage for which are destined. However, fully differentiated individual cell types can be characterized by number mitochondria possess and copies mitochondrial genome per mitochondrion. These characteristics indicative a specific cell's requirement adenosine triphosphate (ATP) therefore cellular viability function. Consequently, failure an ESC to full complement DNA (mtDNA) could limit...
The mammalian heart is a complex organ composed of diverse components and various cell types. Heart organogenesis requires the contribution distinct pools progenitors positioned in separate embryonic regions subject to particular developmental signals. Moreover, these lineages have different transcriptional profiles expressing specific genes which activate pathways involved lineage specification. Understanding molecular control has major implications for treating congenital adult diseases...
Understanding the molecular pathways regulating cardiogenesis is crucial for early diagnosis of heart diseases and improvement cardiovascular disease. During normal mammalian cardiac development, collagen calcium-binding EGF domain-1 (Ccbe1) expressed in first second field progenitors as well proepicardium, but its role commitment remains unknown. Here we demonstrate that during mouse embryonic stem cell (ESC) differentiation Ccbe1 upregulated upon emergence Isl1- Nkx2.5- positive...
Introduction Mindfulness refers to a process that leads mental state characterized by non-judgmental awareness of the present moment experience, including one´s sensations, thoughts, bodily states, consciousness, and environment, while encouraging openness, curiosity, acceptance. Objectives The purpose this paper is review ways in which cognitive behavioural treatments for depression anxiety have been advanced application mindfulness practices. Methods Brief non-systematic literature on...
Introduction Valproate is widely used in the treatment of maniac and mixed episodes well known to be safe with side effects being mostly related hepatic disorders psychomotor retardation. Objectives Raising attention valproate-induced hypothyroidism that despite increasing evidence tends neglected. Methods Here, we report a case 55-year-old woman, previous diagnosis schizophrenia, treated for many years 200mg zuclopenthixol triweekly 2mg risperidone daily. Patient developed episode...
Introduction Irritable bowel syndrome (IBS) is the most common functional gastrointestinal disorder, affecting about 20% of people worldwide. This complex and multifaceted disorder has been proposed as a system disease involving not only individual systems including nervous, endocrine, imune, digestive, microbiota environment but also interactions these systems. The aetiology IBS incompletely understood this are frequently associated with comorbid psychiatric disease. Current treatment...
Introduction Depression is a leading cause of disability affecting over 300 million indivuals worldwide. About 1/3 patients with depression fail to achive remission despite treatment multiple antidepressants and are considered have treatment-resistant (TRD). In view such facts, vagus nerve stimulation (VNS) therapy was approved as an adjunctive long-term for TRD. Objectives The authors elaborate narrative literature review about de effectiveness VNS in Methods PubMed database searched using...
Introduction In late 2019, an epidemic outbreak emerges in China caused by a new coronavirus with high transmission and human infection potential which March 2020, was characterized WHO as pandemic. The lockdown has repercussions on the population’s well-being, reflected their food choices. There is tendency to increase consumption of energy dense food, rich fat carbohydrates, are related increased risk depression. Objectives main goal this non-systematic literature review understand impact...
Introduction Major depressive disorder is a highly prevalent clinical condition, affecting more than 300 million individuals worldwide. About 1/3 of patients with MDD fail to achieve remission despite treatment multiple antidepressants and are considered have treatment-resistant depression (TRD). Novel rapid sustained effects on mood cognition could represent breakthrough in the TRD may potentially improve or save lives. Psilocybin, classic hallucinogen, commonly found Psilocybe mushrooms...
Case-report of CPAP-induced manic episodes:Here we report a case 53-year-old man with no personal or family history psychiatric illness.He has medical untreated dyslipidemia and hypertension.