A5070654819- Aquaculture Nutrition and Growth
- Aquaculture disease management and microbiota
- Pluripotent Stem Cells Research
- Ubiquitin and proteasome pathways
- Plant biochemistry and biosynthesis
- Prosthetics and Rehabilitation Robotics
- Physiological and biochemical adaptations
- Lipid metabolism and biosynthesis
- Glycosylation and Glycoproteins Research
- Peptidase Inhibition and Analysis
- Epigenetics and DNA Methylation
- Endoplasmic Reticulum Stress and Disease
- Diabetic Foot Ulcer Assessment and Management
- Cancer Cells and Metastasis
- Lipid Membrane Structure and Behavior
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- TGF-β signaling in diseases
- CRISPR and Genetic Engineering
- SARS-CoV-2 and COVID-19 Research
- Neonatal Respiratory Health Research
- RNA modifications and cancer
- Cerebral Palsy and Movement Disorders
- Spinal Cord Injury Research
- Mosquito-borne diseases and control
Instituto Gulbenkian de Ciência
2025
Portuguese Sea and Atmosphere Institute
2017-2025
University of Algarve
2009-2022
University of Cologne
2009-2022
Clinical Academic Center of Braga
2022
University Medical Center Groningen
2021
University of Groningen
2020-2021
Hospital Braga
2014-2020
University of Aveiro
2019
University of Lisbon
2007-2011
Introduction: Early reports showed that Omicron (BA.1) SARS-CoV-2 could be less severe. However, the magnitude of risk reduction hospitalization and mortality infections compared with Delta (B.1.617.2) is not yet clear. This study compares severe disease among patients infected variant in Portugal.Methods: We conducted a cohort individuals diagnosed infection between 1st 29th December 2021. Cases were positive PCR test notified to national surveillance system. variants classified first by...
Marine aquaculture has witnessed remarkable growth in recent decades, contributing significantly to global food security and economic development [...]
Abstract Monitoring gait and posture while using assisting robotic devices is relevant to attain effective assistance assess the user’s progression throughout time. This work presents a multi-camera, multimodal, detailed dataset involving 14 healthy participants walking with wheeled walker equipped pair of affordable cameras. Depth data were acquired at 30 fps synchronized inertial from Xsens MTw Awinda sensors kinematic segments biomechanical model, 60 Hz. Participants walked 3 different...
Abstract Introduction Early reports showed that Omicron (BA.1) SARS-CoV-2 could be less severe. However, the magnitude of risk reduction hospitalization and mortality infections compared with Delta (B.1.617.2) is not yet clear. This study compares severe disease among patients infected variant in Portugal. Methods We conducted a cohort individuals diagnosed infection between 1 st 29 th December 2021. Cases were positive PCR test notified to national surveillance system. variants classified...
The 26S proteasome is a non-lysosomal protease in the cytosol and nucleus of eukaryotic cells. Its main function to mediate ubiquitin-dependent proteolysis. multimeric complex composed by 20S CP (core particle) 19S RPs (regulatory particles). Although atomic structure has not yet been determined, high-resolution structures are available for its CP. Studies on complicated assembly pathway have revealed that it involves an unprecedented number dedicated chaperones. Assembly alone three...
Identifying novel players of the pluripotency gene regulatory network centered on Oct4, Sox2, and Nanog as well delineating interactions within complex is key to understanding self-renewal early cell fate commitment embryonic stem cells (ESC). While overexpression transcriptional regulator Cited2 sustains ESC pluripotency, its role in functions remains unclear. Here, we show that important for proliferation, survival, mouse ESC. We position by defining Nanog, Tbx3, Klf4 direct targets. also...
The transcriptional regulator CITED2 is essential for heart development. Here, we investigated the role of in specification cardiac cell fate from mouse embryonic stem cells (ESC). overexpression undifferentiated ESC was sufficient to promote emergence upon differentiation. Conversely, depletion Cited2 at onset differentiation resulted a decline ability generate cells. Moreover, loss expression impairs early mesoderm markers and cardiogenic transcription factors (Isl1, Gata4, Tbx5). defects...
Transforming growth factor (TGF)-β-induced myofibroblast transformation and alterations in mesenchymal-epithelial interactions contribute to chronic lung diseases such as obstructive pulmonary disease (COPD), asthma fibrosis. Rho-associated coiled-coil-forming protein kinase (ROCK) consists two isoforms, ROCK1 ROCK2, both are playing critical roles many cellular responses injury. In this study, we aimed elucidate the differential role of ROCK isoforms on TGF-β signaling fibrosis repair. For...
Efforts have been made to find alternatives fish meal (FM), as the sustainability of aquaculture depends on it. Insect (IM) is a potential candidate partially replace FM, being more sustainable and economically viable. In this experimental trial, three diets were tested with different yellow mealworm incorporation: control diet no IM, an inclusion 10% IM (Ins10), incorporation 20% (Ins20). The 10.5 g meagre for 47 days. results showed that higher than affected both growth (2.6 vs. 2.2) FCR...
On this paper a vision-based contact- and markerless method for gait evaluation is proposed, validated in different experimental setups against commercial motion capture systems (Vicon) inertial analysis tools (GaitShoes). While the development goal its integration on ASBGo Smart Walker platform, only an inexpensive depth camera required. It shown to have reasonable results when computing metrics real time, setups, from walker types, vision hardware walking scenarios. Performance evaluated...
It is important to verify the potential of assistive technology like smart walkers and their long-term effects in rehabilitation therapies. Thus, this study introduced a walker an ataxic patient during 3 weeks. His gait pattern postural stability was acquired evaluated. Great improvements parameters as well were observed.