A5062546180- Corneal surgery and disorders
- Glaucoma and retinal disorders
- Ocular Surface and Contact Lens
- Corneal Surgery and Treatments
- Ophthalmology and Visual Impairment Studies
- Chronic Lymphocytic Leukemia Research
- Receptor Mechanisms and Signaling
- Allergic Rhinitis and Sensitization
- Intraocular Surgery and Lenses
- Platelet Disorders and Treatments
- Lymphoma Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Urticaria and Related Conditions
- Retinal Development and Disorders
- Blood groups and transfusion
- Monoclonal and Polyclonal Antibodies Research
- Autoimmune Bullous Skin Diseases
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Neuropeptides and Animal Physiology
- Quantum Information and Cryptography
- Photoreceptor and optogenetics research
- Cardiovascular Function and Risk Factors
- Pharmacological Effects of Natural Compounds
- Immunodeficiency and Autoimmune Disorders
- Glycosylation and Glycoproteins Research
University Hospital of North Norway
2014-2024
Novartis (Switzerland)
2016-2024
UiT The Arctic University of Norway
2021-2024
University of Applied Health Sciences
2024
Novartis Institutes for BioMedical Research
2016-2022
Institute of Orthopedics Banjica
2022
Ten Chen Hospital
2022
Oslo University Hospital
2009-2021
London Vision Clinic
2021
University of Ulster
2021
PURPOSE: To evaluate a combination of topography-guided custom ablation and corneal collagen cross-linking (CXL) in single procedure for the treatment keratectasia. METHODS: Twelve eyes 12 patients with keratectasia were treated CXL. Topography-guided was performed using transepithelial technique iVIS Suite 1 kHz flying spot excimer laser. Collagen immediately after ablation, according to standard protocol. Postoperative follow-up examinations at 1, 3, 6, months. Uncorrected visual acuity...
The appearance of protein aggregates is a characteristic misfolding disorders including familial amyotrophic lateral sclerosis, neurodegenerative disease caused by inherited mutations in Cu/Zn superoxide dismutase 1 (SOD1). Here, we use live cell imaging neuronal and nonneuronal cells to show that SOD1 mutants (G85R G93A) form an aggregate structure consisting immobile scaffolds, through which noninteracting cellular proteins can diffuse. Hsp70 transiently interacts, chaperone...
Lipoprotein lipase (LPL) plays a central role in triglyceride (TG) metabolism. By catalyzing the hydrolysis of TGs present TG-rich lipoproteins (TRLs), LPL facilitates TG utilization and regulates circulating TRL concentrations. Until very recently, structural information for was limited to homology models, presumably due propensity unfold aggregate. coexpressing with soluble variant its accessory protein glycosylphosphatidylinositol-anchored high-density lipoprotein binding 1 (GPIHBP1)...
PURPOSE: To assess the repeatability of corneal epithelial thickness mapping in virgin, post-laser refractive surgery (PLRS), and keratoconic eyes using a novel swept-source optical coherence tomographer (SS-OCT), to determine agreement measurements with validated spectral-domain (SD) OCT. METHODS: Analysis 90 46 PLRS, 122 was performed. Three consecutive each eye were acquired Anterion SS-OCT Avanti SD-OCT devices, averages calculated central 2-mm zone 2- 5-mm 5- 7-mm diameter rings. The...
Purpose . To evaluate the efficacy and safety of epithelium-on corneal collagen cross-linking (CXL) using a multifactorial approach to achieve proper stromal riboflavin saturation. Methods This non-randomized retrospective study comprised 61 eyes with progressive keratoconus treated CXL. Chemical epithelial penetration enhancement (benzalkonium chloride-containing local medication hypotonic solution), mechanical disruption superficial epithelium, prolongation riboflavin-induction time until...
Our main purpose was to compare safety and efficacy in the treatment of progressive keratoconus with "epithelium-on" "epithelium-off" corneal collagen cross-linking (CXL). secondary evaluate CXL when hypotonic 0.5% riboflavin is used as photosensitizer.One eye 20 patients bilateral randomly treated for (group 1) while fellow underwent 2). Hypotonic both groups. Visual acuity, refraction, topography, wavefront aberrometry were evaluated at baseline after 1, 6, 12 months. Specular microscopy...
To study the corneal epithelial and stromal thickness profile changes after photorefractive keratectomy (PRK) for myopia.Retrospective analysis of postoperative in 46 left eyes patients treated with PRK myopia. Corneal maps within central 6 mm were obtained by anterior segment spectral-domain optical coherence tomography preoperatively at 1, 3, months postoperatively. Stromal was calculated subtracting from total thickness. Correlations between amount correction, treatment zone, preoperative...
To investigate the correlation between environmental changes in ultraviolet (UV) radiation levels and incidence of late-onset cornea haze (LOCH) after photorefractive keratectomy (PRK).SynsLaser Clinic, Tromsø, Norway.The study comprised 404 eyes that had myopic PRK photoastigmatic refractive from February 1996 through July 1998. The high latitude (70 degrees N) observation site provided "natural laboratory" conditions to look at occurrence LOCH with low UV-radiation levels, which occurred...
Purpose To identify corneal epithelial- and stromal-thickness distribution patterns in keratoconus using spectral-domain optical coherence tomography (SD-OCT). Patients Methods We analyzed SD-OCT findings 20 confirmed cases of (group 1) healthy subjects with astigmatism ≥2 D 2). Epithelial stromal thicknesses were measured at 11 strategic locations along the steepest flattest meridians, previously located by topography. Vertical mirrored symmetry superimposition was used statistical...
Purpose To determine the measurement reliability of CorVis ST, a dynamic Scheimpflug analyser, in virgin and post-photorefractive keratectomy (PRK) eyes compare results between these two groups. Methods Forty 42 post-PRK underwent ST measurements performed by technicians. Repeatability was evaluated comparing three consecutive technician A. Reproducibility determined first A with one B. Intraobserver interobserver intraclass correlation coefficients (ICCs) were calculated. Univariate...
Purpose: To assess repeatability and agreement of corneal epithelial thickness mapping in eyes with keratoconus using three optical coherence tomography (OCT) devices featuring different technologies: spectral-domain (SD) OCT combined Placido disk topography (MS-39), swept-source (Anterion), SD-OCT (Avanti). Methods: Three consecutive measurements were acquired the 60 keratoconus. The mean was calculated central 2-mm zone 2- to 5-mm 5- 7-mm diameter rings. pooled within-subject standard...
To evaluate the efficacy and safety of a single-step, transepithelial, topography-guided surface ablation in treatment visual disturbances including irregular astigmatism light scattering caused by LASIK flap or interface complications.Seventeen eyes 16 patients with complications central residual stromal thickness ≥300 μm were treated custom transepithelial "no touch" (cTEN) technique using iVIS Suite 1-kHz excimer laser (iVIS Technology). Uncorrected distance acuity (UDVA), corrected...
The aim of this study was to report the 12 96 months results a tissue-preservation algorithm based on ray-tracing-guided transepithelial excimer laser central corneal ablation (RT t-PRK) combined with individualized pachymetry-guided accelerated crosslinking (M nomogram ACXL) in young adult patients stable keratoconus (KC).
To evaluate repeatability and agreement in measurements of total corneal astigmatism (TCA) keratoconic eyes, using four optical coherence tomography (OCT)-based devices: Anterion, Casia SS-1000, IOLMaster 700, MS-39.
ABSTRACT PURPOSE: To evaluate whether prophylactic systemic ascorbic acid influences the average level of haze and incidence late onset corneal after photorefractive keratectomy (PRK). METHODS: Two consecutive groups eyes treated with PRK for myopia or without astigmatism were retrospectively compared. The patients had been similarly, exception that ascorbate supplied orally in one groups. Haze intensity was quantified on a scale from 0 (clear cornea) to 4 (anterior chamber not visible)....
The aim of the study is to raise awareness influence coma-like higher-order aberrations (HOAs) on power and orientation refractive astigmatism (RA) explore how account for that in planning topography-guided surgery eyes with coma-like-aberrations-dominant corneal optics.Eleven optics low lenticular (LA) were selected analysis treatment simulations custom ablation. Vector was used evaluate contribution HOAs RA. Two different strategies simulated treatments aiming regularize irregular optics:...
An imidazolone → triazolone replacement addressed the limited passive permeability of a series protein arginine methyl transferase 5 (PRMT5) inhibitors. This increase in was unexpected given hydrogen bond acceptor (HBA) count and topological polar surface area (TPSA), two descriptors that are typically inversely correlated with permeability. Quantum mechanics (QM) calculations revealed this unusual effect due to an electronically driven disconnect between TPSA 3D-PSA, which manifests...
Rhodopsin is the dim-light activated photoreceptor located in rod cells of eye. It belongs to large superfamily G-protein-coupled receptors (GPCRs). Many consider it prototypical GPCR as numerous studies since its cloning 1983 (Nathans and Hogness 1983) have established many fundamental principles seven transmembrane-spanning GPCRs. Abundant expression rod's outer segment, constituting about 90% total membrane protein discs, development techniques purify quantities functional has facilitated...
The human prostacyclin receptor is a seven-transmembrane α-helical G-protein coupled receptor, which plays important roles in both vascular smooth muscle relaxation as well prevention of blood coagulation. position the native ligand-binding pocket for other derivatives 20-carbon eicosanoid, arachidonic acid, has yet to be determined. Through use prostanoid sequence alignments, site-directed mutagenesis, and 2.8-Å x-ray crystallographic structure bovine rhodopsin, we have developed...
Zinc deficiency and retinitis pigmentosa are both important factors resulting in retinal dysfunction night blindness. In this study, we address the critical biochemical structural relevance of zinc ions rhodopsin examine whether can lead to dysfunction. We report identification a high-affinity coordination site within transmembrane domain rhodopsin, coordinated by side chains two highly conserved residues, Glu(122) helix III His(211) V. also demonstrate that is for folding, 11-cis-retinal...
<h4>PURPOSE</h4><p>To compare treatments with wavefront optimized and custom-Q ablations.</p> <h4>METHODS</h4><p>Two consecutive groups of eyes were treated for myopia astigmatism surface ablation. One group was ablation the second Preoperative 3-month postoperative Q-values, higher order aberrations, low contrast visual acuity, classic outcome parameters analyzed.</p> <h4>RESULTS</h4><p>The comprised 46 23 patients a mean...
PURPOSE: To compare the severity of postoperative pain and rate penetration riboflavin between eyes treated by corneal crosslinking (CXL) using excimer laser superficial epithelial removal mechanical full-thickness removal. SETTING: Departments Ophthalmology, Ullevål University Hospital, Oslo, Hospital Northern Norway, Tromsø, Norway. METHODS: Patients with ectasia were programmed to 35 μm phototherapeutic keratectomy (Group 1) or a brush 2). Pain was evaluated postoperatively patients'...