A5070558349- Genetic Associations and Epidemiology
- Complement system in diseases
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Blood groups and transfusion
- Cardiovascular Function and Risk Factors
- Inflammatory mediators and NSAID effects
- Atrial Fibrillation Management and Outcomes
- Diabetes and associated disorders
- Immunodeficiency and Autoimmune Disorders
- Immune Response and Inflammation
- Lipoproteins and Cardiovascular Health
- Congenital heart defects research
- Genetic Mapping and Diversity in Plants and Animals
- Genetic and phenotypic traits in livestock
- Peroxisome Proliferator-Activated Receptors
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Dermatology and Skin Diseases
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Adenosine and Purinergic Signaling
- Mast cells and histamine
- Cardiac electrophysiology and arrhythmias
- Maternal and fetal healthcare
- Oral microbiology and periodontitis research
Helsinki University Hospital
2016-2019
University of Helsinki
2006-2019
Finnish Red Cross
1982-2002
Pediatrics and Genetics
1996
Washington University in St. Louis
1996
Preeclampsia (PE) is a common disorder of pregnancy originating in the placenta. We examined whether excessive activation or poor regulation complement system at maternal-fetal interface could contribute to development PE. Location and occurrence components regulators placentae were analyzed. Cryostat sections processed from 7 early-onset PE (diagnosis <34 weeks gestation), 5 late-onset PE, 10 control pregnancies, immunostained for 6 activators inhibitors. Fluorescence was quantified...
Type II complement protein C2 deficiency is characterized by a selective block in secretion. The null allele (C2Q0) linked to two major histocompatibility haplotypes (MHC) that differ from the MHC of more common I deficiency. To determine molecular basis C2Q0 genes were isolated and transfected separately into L-cells. Subsequent biology, biosynthetic, immunofluorescence studies demonstrated secretion impaired because different missense mutations at highly conserved residues each alleles....
Immunogenetic factors predisposing to recurrent genital herpes remain poorly characterized.In a prospective case-control study, 52 consecutive patients with frequently recurring outbreaks of were compared 80 simplex virus (HSV)-seropositive (types 1 and 2) 70 HSV-seronegative control subjects. Immunoglobulins (Igs), type-specific anti-HSV-2 IgG subclass antibodies against glycoprotein G, levels C3 C4, classical pathway hemolytic complement activity measured, IgG1 IgG3 allotyping; C4...
Abstract Owing to the vast amount of alleles, high‐resolution human leukocyte antigen ( HLA ) typing is expensive and time‐consuming. Scientists have attempted develop computational approaches define alleles with high confidence. We tested reliability * IMP SNP2HLA for imputing HLA‐DRB1 in a Finnish material n = 161). The per‐individual success rates varied between 16.68% 25.4% using both softwares. One most prominent example was *01:01 allele showing approximately 30% rate while being...
Abstract Severe forms of chronic periodontitis affect up to 10% adults. Tumour necrosis factor and lymphotoxin‐ α genes in the major histocompatibility complex are associated with severe periodontitis. Complement C4 is a nearby, polymorphic, functionally relevant gene region. Although mucosal infections, deficiencies have not been assessed adult patients. We tested whether complement levels systemically altered In case–control study, we analysed plasma C3, C4, serum classical pathway...
Abstract Periodontitis and coronary artery disease (CAD) are inflammatory diseases associated with each other. The major histocompatibility complex (MHC) region carries genes involved in immune response inflammation. We investigated whether the MHC correlate presence of periodontitis or occurrence periodontal pathogens patients CAD. Blood saliva samples from CAD ( n = 106) were collected at time hospitalization. Nine genetic markers [human leukocyte antigen (HLA)‐A, HLA‐B, HLA‐DRB1,...
Within the framework of EU-funded HLA-NET action, an analysis three G-group alleles, HLA-B*44:02:01G, DRB1*14:01:01G and DQB1*03:01:01G, was undertaken in 12 European populations. Ambiguities were resolved by polymerase chain reaction-sequence-specific amplification (PCR-SSP) or PCR-sequence-based typing (PCR-SBT) a total 5095 individuals. The results DRB1*14:01/14:54 ambiguity showed high relative ratios (24-53%) DRB1*14:01 Bulgarians, Croatians, Greeks, Italians Slovenians, contrasting...
The HLA‐A,B,C gene and haplotype frequencies calculated by the direct counting method from genotypes of 550 unrelated Finns are reported. typings were done during years 1978‐1980. delta values given for HLA‐A,B B,C haplotypes. Some comparisons between other European populations stated.
Five patients with exercise-induced anaphylactoid reactions are reported. Because of a growing interest in physical exercise and the severity symptoms it is important to recognize this condition, even though rare. All our 5 had history urticaria anaphylaxis association stress, but seems difficult induce under laboratory conditions. Two different clinical patterns could be distinguished these patients. Three form signs alternative complement pathway activation, while 2 variant presenting...
SUMMARY Major Histocompatibility Complex (MHC) class III located complement C4 and steroid 21‐hydroxylase (21OH) genes, which form various deletion duplication units, were studied by Taq I Restriction Fragment Length Polymorphism (RFLP) in 58 Finnish couples who suffered recurrent spontaneous abortions (RSA). The gene rearrangements found the RSA did not differ from those controls.