A5021625036- Neonatal Respiratory Health Research
- Asthma and respiratory diseases
- Congenital Diaphragmatic Hernia Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Birth, Development, and Health
- Epigenetics and DNA Methylation
- Air Quality and Health Impacts
- CRISPR and Genetic Engineering
- Protease and Inhibitor Mechanisms
- Congenital Heart Disease Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Respiratory Support and Mechanisms
- Tracheal and airway disorders
- Gene expression and cancer classification
- Gene Regulatory Network Analysis
- Pluripotent Stem Cells Research
- Vitamin D Research Studies
- Maternal and Neonatal Healthcare
- Neonatal and Maternal Infections
- Ectopic Pregnancy Diagnosis and Management
- Single-cell and spatial transcriptomics
- Organoselenium and organotellurium chemistry
- Vehicle emissions and performance
- Pregnancy and Medication Impact
- Child and Adolescent Health
University of Rochester Medical Center
2023-2024
Northwestern Medicine
2023
Women's Hospital
2023
Lurie Children's Hospital
2023
New York State Office of Mental Health
2022
University of California, San Diego
2014-2021
National Jewish Health
2019-2021
University of Colorado Denver
2019-2021
Columbia University
2020
Cornell University
2020
Low vitamin D status in pregnancy was proposed as a risk factor of preeclampsia.We assessed the effect supplementation (4,400 vs. 400 IU/day), initiated early (10-18 weeks), on development preeclampsia. The effects serum (25-hydroxyvitamin [25OHD]) levels preeclampsia incidence at trial entry and third trimester (32-38 weeks) were studied. We also conducted nested case-control study 157 women to investigate peripheral blood D-associated gene expression profiles 10 18 weeks 47 participants...
In utero smoke exposure has been shown to have detrimental effects on lung function and be associated with persistent wheezing asthma in children. One potential mechanism of IUS could alterations DNA methylation, which may life-long implications. The goal this study was examine the association between methylation nicotine fetal placental tissue early development; analysis represents a likely surrogate for in-utero smoke. We performed an epigenome-wide (n = 85, 41 exposed (48%), 44 controls)...
Exacerbations of chronic obstructive pulmonary disease (COPD), characterized by acute deterioration in symptoms, may be due to bacterial or viral infections, environmental exposures, unknown factors. Exacerbation frequency a stable trait COPD patients, which could imply genetic susceptibility. Observing the genes, networks, and pathways that are up- down-regulated patients with differing susceptibility exacerbations will help elucidate molecular signature pathogenesis exacerbations.Gene...
Abstract Genomic aberrations have been identified in many human pluripotent stem cell (hPSC) cultures. Commonly observed duplications portions of chromosomes 12p and 17q associated with increases genetic instability resistance to apoptosis, respectively. However, the phenotypic consequences related sporadic mutations not evaluated date. Here, we report on effects a single-copy deletion chr17p13.1 region, mutation that spontaneously arose independently several subclones embryonic culture....
In this study, we show that methylselenol, a selenometabolite implicated in cancer prevention, did not directly inactivate protein kinase C (PKC). Nonetheless, its oxidation product, methylseleninic acid (MSA), inactivated PKC at low micromolar concentrations through redox modification of vicinal cysteine sulfhydryls the catalytic domain PKC. This occurred both isolated form and intact cells was reversed by reductase system involving thioredoxin reductase, selenoprotein. isoenzymes exhibited...
Background Patterns of gene expression human pregnancy are poorly understood. In a trial vitamin D supplementation in pregnant women, peripheral blood transcriptomes were measured longitudinally on 30 women and used to characterize co-expression networks. Objective Studies suggest that increased maternal Vitamin levels may reduce the risk asthma early life, yet underlying mechanisms have not been examined. this study, we network-based approach examine changes profiles during course normal...
Exposure to air pollution, including traffic-related pollutants, has been associated with a variety of adverse health outcomes, increased cardiopulmonary morbidity and mortality, lung cancer risk.To better understand the cellular responses induced by pollution exposures, we performed genome-wide gene expression microarray analysis using whole blood RNA sampled at three time-points across work weeks 63 non-smoking employees 10 trucking terminals in northeastern US. We defined genes networks...
The fetal origins of disease hypothesis suggests that variations in the course prenatal lung development may affect life-long pulmonary function growth, decline, and pathobiology. Many studies support existence differences developing trajectory males females, sex-specific prevalence chronic diseases, such as asthma bronchopulmonary dysplasia. objectives this study were to investigate early for transcriptomic correlates postconception age (maturity) sex, their associations with diseases. We...
Biological systems are increasingly being studied by high throughput profiling of molecular data over time. Determining the set time points to sample in studies that profile several different types is still challenging. Here we present Time Point Selection (TPS) method solves this combinatorial problem a principled and practical way. TPS utilizes expression from small genes sampled at rate. As show applying study mouse lung development, selected can be used reconstruct an accurate...
Antenatal corticosteroids enhance lung maturation. However, the importance of glucocorticoid genes on early development, asthma susceptibility, and treatment response remains unknown. We investigated whether are important during development their role in susceptibility response. identified that were differentially expressed by two three genomic datasets: lymphoblastoid cell lines participants Childhood Asthma Management Program, a chromatin immunoprecipitation/RNA sequencing experiment, or...
A comprehensive understanding of the dynamic regulatory networks that govern postnatal alveolar lung development is still lacking. To construct such a model, we profiled mRNA, microRNA, DNA methylation, and proteomics developing murine alveoli isolated by laser capture microdissection at 14 predetermined time points. We developed detailed interactive model provides information about major expression trajectories, regulators specific key events, impact epigenetic changes. Intersecting with...
Background: In utero smoke (IUS) exposure is associated with asthma susceptibility. Objective: We sought to test the hypothesis that changes in miRNA expression by IUS during human lung development Methods: Gene was profiled from 53 unexposed and 51 exposed fetal tissues. tested for differential of miRNAs across post-conception age using linear models covariate adjustment. IUS-associated association their gene targets pair-wise inverse correlation. Using our mouse model, we investigated...
Abstract The objective of this study was to compare the knowledge mothers newborns in a neonatal intensive care unit (NICU) and well-baby nursery (WBN) regarding their understanding term gestation, delivery mode safety, elective late preterm delivery. Mothers admitted either an NICU (n=88) or WBN (n=145) were surveyed (March 2008–September 2010). Of all mothers, regardless infant location, 7% unable define 33% unaware that scheduling at 35–36 weeks is not advisable, 30% lacked cesareans are...
The paper presents a novel mechanism to enhance the consumer experience of TV shopping. A customer's can be enhanced, if he/she could interact with smart purchase interesting items leading TV-enabled For this, method is proposed which track and identify multiple objects in video sequence using surf features. Most present object detection methods rely on stable camera location, slow moving or same type times. However, general for shopping, this not case. reason, system trained detect types...
The American Thoracic Society Core Curriculum updates clinicians annually in pediatric pulmonary disease. This is a summary of the Pediatric Pulmonary Medicine presented at 2023 International Conference. respiratory disorders infancy discussed this year's review include: care patient with bronchopulmonary dysplasia neonatal intensive unit, clinical phenotypes and comorbidities; diffuse lung disease; hypertension; central obstructive sleep apnea. infants often poses significant challenges to...