A5069525605- Congenital Heart Disease Studies
- Pulmonary Hypertension Research and Treatments
- Congenital Diaphragmatic Hernia Studies
- Cardiac Structural Anomalies and Repair
- Cardiac Valve Diseases and Treatments
- Cardiovascular Issues in Pregnancy
- Coronary Artery Anomalies
- Cardiovascular Function and Risk Factors
- Pectus Deformity Diagnosis and Treatment
- Infective Endocarditis Diagnosis and Management
- Neonatal Respiratory Health Research
- Respiratory Support and Mechanisms
- Cardiac, Anesthesia and Surgical Outcomes
- Mechanical Circulatory Support Devices
- Lymphatic Disorders and Treatments
- Lymphatic System and Diseases
- Nitric Oxide and Endothelin Effects
- Congenital Anomalies and Fetal Surgery
- Trauma Management and Diagnosis
- Cardiac pacing and defibrillation studies
- Vascular anomalies and interventions
- Metabolism and Genetic Disorders
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Hemodynamic Monitoring and Therapy
- Shoulder and Clavicle Injuries
University of California, Davis
2015-2024
UC Davis Children's Hospital
2006-2024
University of California Davis Medical Center
2010-2022
Shriners Hospitals for Children - Northern California
2016-2017
Beaumont Health
2016
University of California, San Francisco
2004-2008
UCSF Benioff Children's Hospital
2006-2007
Illinois College
2002-2005
Children's Hospital of Illinois
2002-2005
University of Illinois Chicago
2004
Surgical reconstructions or palliations of congenital heart defects often require the utilization patches, which ideal material has yet to be discovered. Recently, porcine small intestinal submucosa extracellular matrix (SIS-ECM) been advocated as an alternative conventional synthetic biological patch material. Here, we present our initial experience with SIS-ECM in paediatric cardiovascular reconstructions. A retrospective review all patients <18 years age who had implanted during surgery...
The prevalence of Down syndrome (DS)-affected births has increased during the past 30 years; moreover, children with DS have a higher incidence congenital heart disease compared their peers. Whether better or worse outcomes after repair is unclear. We sought to identify differences in in-hospital mortality cardiac surgery pediatric patients and without using large national database.Children aged <18 years who underwent surgical intervention for were identified Kids' Inpatient Database (2000,...
Mesothelial inclusion cysts are rare and even more when encountered in around the pericardium. This case report highlights postoperative management of a patient with this disease, combination development chylothorax after mitral valve surgery undefined relationship between two disease processes setting cardiofaciocutaneous syndrome.
Carnitine homeostasis is disrupted in lambs with endothelial dysfunction secondary to increased pulmonary blood flow (Shunt). Our recent studies have also indicated that the disruption carnitine correlates a decrease PPAR-γ expression Shunt lambs. Thus, this study was carried out determine if there causal link between loss of signaling and dysfunction, whether agonist, rosiglitazone preserves lambs.siRNA-mediated knockdown significantly reduced palmitoyltransferases 1 2 (CPT1 2)...
Vascular cell hyperproliferation and metabolic reprogramming contribute to the pathophysiology of pulmonary arterial hypertension (PAH). An important cause PAH in children with congenital heart disease (CHD) is increased blood flow (PBF). To better characterize this course we studied early changes artery smooth muscle (PASMC) proliferation metabolism using a unique ovine model overcirculation. Consistent adults, PASMCs derived from 4-wk-old lambs exposed PBF (shunt) exhibited rates...
Prenatal and early postnatal growth are known to be abnormal in patients with CHD. Although adult metabolic risk is associated later childhood, little of childhood CHD.Retrospective data were collected on 551 coarctation the aorta, hypoplastic left heart syndrome, single ventricle physiology, tetralogy Fallot, transposition great arteries, or ventricular septal defects. Weight, height, body mass index converted Z-scores. Body size at 2 years between 20 years, 7 8 15 compared Normative using...
Patients with pulmonary hypertension associated congenital heart disease survive longer preserved right ventricular (RV) function compared those primary hypertension. The purpose of this study was to test the hypothesis that superior RV performance can be demonstrated, at baseline and when challenged increased afterload, in lambs chronic left-to-right cardiac shunts control lambs. A shunt placed between artery aorta fetal (shunt). pressure-volume loops were obtained 4 wk after delivery...
The natural history of pulmonary vascular disease associated with congenital heart (CHD) depends on hemodynamics. Patients exposed to increased blood flow (PBF) and arterial pressure (PAP) develop more commonly than patients PBF alone. To investigate the effects these differing mechanical forces physiologic molecular responses, we developed two models CHD using fetal surgical techniques: 1) left artery (LPA) ligation primarily resulting in 2) aortopulmonary shunt placement PAP. Hemodynamic,...
Associated abnormalities of the lymphatic circulation are well described in congenital heart disease. However, their mechanisms remain poorly elucidated. Using a clinically relevant ovine model cardiac defect with chronically increased pulmonary blood flow (shunt), we previously demonstrated that exposure to elevated lymph is associated with: 1) decreased bioavailable nitric oxide (NO) lymph; and 2) attenuated endothelium-dependent relaxation thoracic duct rings, suggesting disrupted...
Tenascin-C (TN-C) expression and matrix metalloproteinase (MMP) activity are induced within remodeling pulmonary arteries (PAs), where they promote cell growth. Because vascular disease in children with congenital heart defects is commonly associated changes hemodynamics, we hypothesized that blood flow regulate TN-C MMPs. To test this, ligated the left PAs of neonatal pigs. After 12 wk, evaluated levels MMPs control lung tissue. Modifying hemodynamics increased mRNA protein expression, MMP...
Abnormalities of the lymphatic circulation are well recognized in patients with congenital heart defects. However, it is not known how associated abnormal blood flow patterns, such as increased pulmonary (PBF), might affect function and structure. Using well-established ovine models acute chronic increases PBF, we cannulated efferent duct caudal mediastinal node collected analyzed lymph effluent from lungs lambs acutely PBF (n = 6), chronically age-matched normal 8). When normalized to found...