A5066093494- GDF15 and Related Biomarkers
- Adipose Tissue and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Nutrition and Health in Aging
- Chemotherapy-induced cardiotoxicity and mitigation
- Sirtuins and Resveratrol in Medicine
- Autophagy in Disease and Therapy
- Pancreatic function and diabetes
- Lipoproteins and Cardiovascular Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Lipid metabolism and disorders
- Nuclear Receptors and Signaling
- Liver Disease Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Sperm and Testicular Function
- PARP inhibition in cancer therapy
- Circadian rhythm and melatonin
- Birth, Development, and Health
- Reproductive Physiology in Livestock
- Genetic factors in colorectal cancer
- Animal Behavior and Welfare Studies
- Sexual Differentiation and Disorders
- Ferrocene Chemistry and Applications
- Environmental and Ecological Studies
- Macrophage Migration Inhibitory Factor
Instituto de Salud Carlos III
2018-2023
Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
2018-2023
Hospital Sant Joan de Déu Barcelona
2018-2023
Universitat de Barcelona
2018-2023
Université Sorbonne Nouvelle
2022
Universitat Autònoma de Barcelona
2022
Institut de Biomedicina de la Universitat de Barcelona
2020-2021
Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
2020-2021
Universidad de Zaragoza
2016-2017
University of Montana
2014
Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) activates AMP-activated protein kinase (AMPK) and plays a crucial role in glucose lipid metabolism. Here, we examine whether PPARβ/δ activation effects depend on growth differentiation factor 15 (GDF15), stress response cytokine that regulates energy Pharmacological increases GDF15 levels ameliorates intolerance, fatty acid oxidation, endoplasmic reticulum stress, inflammation, AMPK HFD-fed mice, whereas these are abrogated by the...
Summary Melatonin is a ubiquitous molecule found in wide range of fluids, one them being ram seminal plasma, which it can reach higher concentrations than those blood, suggesting an extrapineal secretion by the reproductive tract. In order to identify source melatonin we first tried determine whether levels were maintained during day. For this purpose, measured plasma obtained from ejaculates six rams at 6:00 a.m. total darkness, 10:00 and 14:00 p.m. The concentration was ( p < 0.05)...
Metformin, the most prescribed drug for treatment of type 2 diabetes mellitus, has been recently reported to promote weight loss by upregulating anorectic cytokine growth differentiation factor 15 (GDF15). Since antidiabetic effects metformin are mostly mediated activation AMPK, a key metabolic sensor in energy homeostasis, we examined whether this kinase was dependent on GDF15.Cultured hepatocytes and myotubes, wild-type Gdf15-/- mice were utilized series studies investigate involvement...
Some melatonin functions in mammals are exerted through MT1 and MT2 receptors. However, there no reports of their presence the reproductive tract ram, a seasonal species. Thus, we have investigated existence ram testis, epididymis, accessory glands ductus deferens. Real-time polymerase chain reaction (qPCR) revealed higher levels m-RNA for both receptors ampulla, seminal vesicles, vas deferens, than other organs (p < 0.05). Western blot analyses showed protein bands compatible with testis...
Abstract Background Peroxisome proliferator-activated receptor γ (PPARγ) coactivator 1α (PGC-1α) downregulation in skeletal muscle contributes to insulin resistance and type 2 diabetes mellitus. Here, we examined the effects of endoplasmic reticulum (ER) stress on PGC-1α levels potential mechanisms involved. Methods The human cell line LHCN-M2 mice exposed different inducers ER were used. Results Palmitate- or tunicamycin-induced resulted enhanced expression activating transcription factor 4...
Abstract Chemokines comprise a family of secreted proteins that activate G protein–coupled chemokine receptors and thereby control the migration leukocytes during inflammation or immune surveillance. The positional information required for such migratory behavior is governed by binding chemokines to membrane-tethered glycosaminoglycans (GAGs), which establishes concentration gradient. An often observed but incompletely understood ability unrelated enhance potency with another subtype can its...
While gender-based differences in heart disease have raised the possibility that estrogen (ES) or progesterone (PG) may cardioprotective effects, recent controversy regarding hormone replacement therapy has questioned cardiac effects of these steroids. Using cardiomyocytes, we tested whether ES PG protective at cellular level. We found but not protects cardiomyocytes from apoptotic cell death induced by doxorubicin (Dox). inhibited apoptosis a dose-dependent manner, 12 ± 4.0% 1 μm and 60...
Whole human testicular tissue, isolated seminiferous tubules and interstitial tissue were incubated with labeled testosterone. Metabolites by paper thin-layer chromatography derivative formation. Results expressed as percentage of substrate added at the beginning incubation, losses being corrected a second isotope. In tubules, metabolic activity was very poor in prepubertal testes but increased adolescent subjects. Among steroids looked for, 5α-androstan-3α,17β-diol dihydrotestosterone main...
Five Argentine Pampinta (dairy breed) and six Corriedale (dual-purpose adult rams were used to study the effect of season on sexual behavior, plasma testosterone (T) semen characteristics for a period 1 year. Scrotal circumference (SC) T concentrations determined at 2-week intervals. Each ram was exposed monthly three ovariectomized ewes in one 20-min test total number mounts successful matings recorded. Semen collection attempted from each twice weekly consecutive weeks during season. In...
Elafibranor is a dual peroxisome proliferator-activated receptor (PPAR)α and β/δ agonist that has reached phase III clinical trial for the treatment of metabolic dysfunction-associated steatotic liver disease (MASLD). Here, we examined effects elafibranor in mice fed choline-deficient high-fat diet (CD-HFD), model steatohepatitis (MASH) presents obesity insulin resistance. Our findings revealed ameliorated steatosis, inflammation, fibrogenesis livers CD-HFD-fed mice. Unexpectedly, also...
Prenatal and early postnatal growth are known to be abnormal in patients with CHD. Although adult metabolic risk is associated later childhood, little of childhood CHD.Retrospective data were collected on 551 coarctation the aorta, hypoplastic left heart syndrome, single ventricle physiology, tetralogy Fallot, transposition great arteries, or ventricular septal defects. Weight, height, body mass index converted Z-scores. Body size at 2 years between 20 years, 7 8 15 compared Normative using...
Abstract Background Endoplasmic reticulum (ER) stress-mediated increases in the hepatic levels of very low-density lipoprotein (VLDL) receptor (VLDLR) promote steatosis by increasing delivery triglyceride-rich lipoproteins to liver. Here, we examined whether NAD( + )-dependent deacetylase sirtuin 1 (SIRT1) regulates lipid accumulation modulating VLDLR and subsequent uptake lipoproteins. Methods Rats fed with fructose drinking water, Sirt1 −/− mice, mice treated ER stressor tunicamycin or...
Abstract Genome editing has exciting potential for gene therapy of cancers. Colorectal cancer is the third most occurring in both men and women. The current treatments colon cancers include surgery, radiofrequency ablation, chemotherapies immunotherapies. These either involve removal intestinal tissue that can alter quality life patient, or require doses drugs generally result various side effects. ABBIE (A Binding Based Integrase Enzyme) genome insert operational sequences into a chosen...
Abstract Peroxisome proliferator-activated receptor β/δ(PPARβ/δ) activates AMP-activated protein kinase (AMPK) and plays a crucial role in glucose lipid metabolism. Here, we examined whether the beneficial effects of PPARβ/δ activation depended on growth differentiation factor 15 (GDF15), stress response cytokine that regulates energy Pharmacological increased GDF15 levels ameliorated intolerance, fatty acid oxidation, endoplasmic reticulum stress, inflammation activated AMPK HFD-fed mice,...