A5051469196- Glioma Diagnosis and Treatment
- Palliative Care and End-of-Life Issues
- Brain Metastases and Treatment
- Meningioma and schwannoma management
- Cardiac, Anesthesia and Surgical Outcomes
- Cerebrospinal fluid and hydrocephalus
- Family and Patient Care in Intensive Care Units
- Cancer Immunotherapy and Biomarkers
- Childhood Cancer Survivors' Quality of Life
- Cancer survivorship and care
- Cerebral Venous Sinus Thrombosis
- Testicular diseases and treatments
- Trigeminal Neuralgia and Treatments
- Teratomas and Epidermoid Cysts
- Management of metastatic bone disease
- Patient Dignity and Privacy
- Head and Neck Surgical Oncology
- Immunotherapy and Immune Responses
- Neurosurgical Procedures and Complications
- Neurofibromatosis and Schwannoma Cases
- Craniofacial Disorders and Treatments
- Cardiac Arrest and Resuscitation
- Pharmaceutical industry and healthcare
- Vascular Malformations Diagnosis and Treatment
- Immune cells in cancer
Stanford University
2019-2025
United States Department of Veterans Affairs
2023-2024
Stanford Health Care
2019-2024
Johns Hopkins University
2015-2024
VA Palo Alto Health Care System
2023-2024
Health Services Research & Development
2023-2024
Center for Innovation
2023-2024
Stanford Medicine
2021-2024
Kaiser Permanente Redwood City Medical Center
2024
Lucile Packard Children's Hospital
2022
The use of inhibitory checkpoint blockade in the management glioblastoma has been studied both preclinical and clinical settings. TIGIT is a novel inhibitor recently discovered to play role cancer immunity. In this study, we sought determine effect anti-PD-1 anti-TIGIT combination therapy on survival murine (GBM) model, elucidate underlying immune mechanisms. Using mice with intracranial GL261-luc+ tumors, found that expression was upregulated CD8+ regulatory T cells (Tregs) brain compared...
Immune checkpoint blockade targeting programmed cell death protein 1 (PD-1) is emerging as an important treatment strategy in a growing list of cancers, yet its clinical benefits are limited to subset patients. Further investigation tumor-intrinsic predictors response and how extrinsic factors, such iatrogenic immunosuppression caused by conventional therapies, impact the efficacy anti-PD-1 therapy paramount. Given widespread use corticosteroids cancer management their immunosuppressive...
Leptomeningeal disease (LMD) from cancer indicates advanced and can lead to obstructive hydrocephalus, for which palliative cerebrospinal fluid (CSF) diversion may be indicated alleviate symptoms. We investigated surgical outcomes hydrocephalus adult patients with LMD conducted a systematic review on pediatric cases. analyzed 10-year period of neoplastic LMD, documented date death. also searched databases inception until 20 August 2022, using search terms including 'cancer', 'hydrocephalus',...
In this study, we show that methylselenol, a selenometabolite implicated in cancer prevention, did not directly inactivate protein kinase C (PKC). Nonetheless, its oxidation product, methylseleninic acid (MSA), inactivated PKC at low micromolar concentrations through redox modification of vicinal cysteine sulfhydryls the catalytic domain PKC. This occurred both isolated form and intact cells was reversed by reductase system involving thioredoxin reductase, selenoprotein. isoenzymes exhibited...
Abstract Background Glioblastoma (GBM) carries a poor prognosis despite standard of care. Early palliative care (PC) has been shown to enhance survival and quality life while reducing healthcare costs for other cancers. This study investigates differences in PC timing on outcomes patients with GBM. Methods used Surveillance, Epidemiology, End Results (SEER)-Medicare data from 1997 2016. Based ICD codes, three groups were defined: (1) early within 10 weeks diagnosis, (2) late PC, (3) no PC....
OBJECT Chiari Type I malformation involves caudal displacement of the cerebellar tonsils below foramen magnum, which obstructs normal cerebrospinal fluid flow and increases intracranial pressure. Certain aspects its surgical treatment remain controversial. A retrospective study was conducted to assess efficacy tonsillar cautery on syrinx resolution among pediatric patients undergoing cervicomedullary decompression. METHODS cohort performed for 0-18 years age who underwent correction with...
Abstract BACKGROUND Sacrificing the superior petrosal vein (SPV) is controversial during a microvascular decompression (MVD). There have been multiple reports of complications including life-threatening brainstem infarction and cerebellar edema. OBJECTIVE To analyze potential for vascular when SPV sacrificed an MVD. METHODS Retrospective chart review was performed to identify all MVDs trigeminal neuralgia hemifacial spasm from 2007 2018 at 1 institution. Cases with ≥1 mo follow-up were...
Recently, several studies have demonstrated that articles disclose conflicts of interests (COI) are associated with publication positive results. The purpose this study was to learn more about the different types COI as they relate general topic in plastic surgery. Specifically, we aimed examine whether likely than others be presentation findings.We reviewed all original Annals Plastic Surgery, Journal Plastic, Reconstructive, and Aesthetic & Reconstructive Surgery from January 1, 2012,...
Objectives: Sports-related concussions (SRCs) are a significant public health concern in athletes. Data exist suggesting link between obesity and decreased neurocognitive function, yet the effect of body mass index (BMI) on function recovery after SRC is unknown. The goal our study was to discern BMI SRC.Methods: This retrospective observational cohort study. Between 2013 2014, 7,606 athletes ages 13–20 years valid baseline testing performed at multiple regional concussion centers sustained...
Pediatric pineoblastomas are highly aggressive tumors that portend poor outcomes despite multimodal management. Controversy remains regarding optimal disease management.To evaluate patterns of care and clinical management pediatric pineoblastoma.A total 211 (age 0-17 yr) histologically confirmed pineoblastoma patients diagnosed between 2004 2015 were queried from the National Cancer Database. Wilcoxon rank-sum statistics chi-squared analyses used to compare continuous categorical variables,...
Patients with primary or secondary central nervous system (CNS) malignancies benefit from utilization of palliative care (PC) in addition to other supportive services, such as home health and social work. Guidelines propose early initiation PC for patients advanced cancers. We analyzed a cohort privately insured malignant brain spinal tumors derived the Optum Clinformatics Datamart Database investigate disparities access services. introduce novel construct, "provider patient racial diversity...