A5102912689- Renal cell carcinoma treatment
- Nanoplatforms for cancer theranostics
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Nanoparticle-Based Drug Delivery
- Renal and Vascular Pathologies
- Cancer, Hypoxia, and Metabolism
- Vascular anomalies and interventions
- Liver Disease and Transplantation
- Heme Oxygenase-1 and Carbon Monoxide
- Neuroinflammation and Neurodegeneration Mechanisms
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- RNA Interference and Gene Delivery
- Cardiac Ischemia and Reperfusion
- Neurological Disease Mechanisms and Treatments
- Venous Thromboembolism Diagnosis and Management
- Adrenal and Paraganglionic Tumors
- Genetic and Kidney Cyst Diseases
- Liver physiology and pathology
- Abdominal Trauma and Injuries
- Organ Transplantation Techniques and Outcomes
- Trauma and Emergency Care Studies
- Cancer, Lipids, and Metabolism
- Pancreatic and Hepatic Oncology Research
- MRI in cancer diagnosis
Chinese PLA General Hospital
2014-2024
PLA Academy of Military Science
2022
Chinese People's Liberation Army
2018
China Huadian Corporation (China)
2007
Chronic nonhealing wounds have imposed serious challenges in the clinical practice, especially for patients infected with multidrug-resistant microbes. Herein, we developed an ultrasmall copper sulfide (covellite) nanodots (CuS NDs) based dual functional nanosystem to cure bacteria-infected chronic wound. The could eradicate bacteria and expedite wound healing simultaneously owing photothermal effect remote control of copper-ion release. antibacterial results indicated that combination...
Abstract The high reactive oxygen species (ROS) generation ability and simple construction of sonosensitizer systems remain challenging in sonodynamic therapy against the hypoxic tumor. In this work, we rationally prepared MOF‐derived double‐layer hollow manganese silicate nanoparticle (DHMS) with highly effective ROS yield under ultrasound irradiation for multimodal imaging‐guided (SDT). presence Mn DHMS increased efficiency because it could be oxidized by holes to improve electron–hole...
Abstract Triple‐negative breast cancer (TNBC) is a kind of aggressive malignancy with fast metastatic behavior. Herein, nanosystem loaded near‐infrared (NIR) agent developed to achieve chemo‐photothermal combination therapy for inhibiting tumor growth and metastasis in TNBC. The NIR ultrasmall sized copper sulfide nanodots strong light‐absorbing capability entrapped into the doxorubicin‐contained temperature‐sensitive polymer‐based by self‐assembled method. temperature sensitive nanoclusters...
Abstract: BACKGROUND: Hemorrhagic shock (HS) causes severe organ damage, worsened by high-altitude conditions with lower oxygen and temperatures. Existing research lacks specific insights on brain heart damage under these conditions. This study hypothesizes that cold (HAC) environments exacerbate HS-induced in the heart, aiming to improve treatment strategies. MATERIALS AND METHODS: Twenty-four male Sprague-Dawley (SD) rats (200–250 g of weight) were randomly assigned into sham, HS + normal,...
This study aimed to investigate the impact of abdominal aortic occlusion (AAO)- induced injury on kidney, lower limb muscles, heart, and brain in mice, potential protective effects hypoxic postconditioning (HyC). The experimental design employed an (AAO) model, involved three groups mice: sham, AAO, AAO+HyC. Ten minutes after AAO mice were subjected treatment lowering oxygen concentration 5% within 45 minutes, then returned a normal environment. Hematoxylin- eosin (HE) stain was used for...
The objective of this study was to characterize the effect albumin therapy on expression Toll-like receptor 4 (TLR 4), anti-inflammation cytokines and CD4+CD25+forkhead box P3 (Foxp3)+ regulatory T lymphocytes (Treg cells) in ischemic brain peripheral immune system after Middle Cerebral Artery Occlusion (MCAO). Adult male Kunming mice were subjected MCAO, suture withdrawn 2 h later followed by an intravenous administration 25% (1.25 g/kg) or saline (5 ml/kg) through caudal vein. We...
Immune cells, including neutrophils, natural killer (NK) T NKT cells and macrophages, participate in the progression of acute liver injury hepatic recovery. To date, there has been no systematic study on quantitative changes these different immune from initial to subsequent recovery.To investigate infiltration various models over time, relationship between leukocyte cell-derived chemotaxin 2 (LECT2) several cells.Carbon tetrachloride- concanavalin A-induced were employed mimic toxin-induced...
To evaluate the method and effectiveness of Angio-CT-guided transcatheter arterial chemoembolization (TACE) immediately in combination with radiofrequency ablation (RFA) treatment large hepatocellular carcinomas (HCCs; maximum enhancing diameter >5 cm).A retrospective analysis was conducted on 48 patients solitary HCCs who were admitted from October 2012 to June 2016 treated by immediate therapy, a sequential (RFA at 2-4 weeks after TACE) therapy same period randomly selected as controls....
Background A quantitative nephrometry scoring system specifically for renal sinus tumors will assist in classifying surgical complexity and treatment planning. Methods By using preoperative computed tomography, magnetic resonance imaging, 3‐dimensional image reconstruction, 5 critical components were assessed: the ratio of area occupied by tumor relation to whole (R), compression segmental vessels or collection (O), anteroposterior relative (A), diameter (D), whether affects a solitary...
Abstract Objective Transcatheter Arterial Chemoembolization (TACE) is the first choice for treatment of advanced-stage hepatocellular carcinoma (HCC). However, TACE suffers from a lack specificity and rapid drug release. Herein, targeted redox-responsive peptide (TRRP) was synthesized used as carrier doxorubicin (DOX) to enhance efficacy through tumor cells targeting controlled Methods TRRP has high loading capacity DOX sensitive release behavior at glutathione (GSH) concentration. Moreover,...
Abstract Background Ischemic stroke (IS) is a cerebrovascular disease with high incidence and mortality. White matter repair plays an important role in the long‐term recovery of neurological function after cerebral ischemia. Neuroprotective microglial responses can promote white protect ischemic brain tissue. Aims The aim this study was to investigate whether hypoxic postconditioning (HPC) IS, mechanism polarization HPC treatment. Materials & Methods Adult male C57/BL6 mice were randomly...
Currently, treatment of symptomatic polycystic liver disease (PLD) is still a challenging problem, especially for these patients who are not feasible surgery. Minimally invasive options such as laparoscopic fenestration and percutaneous cyst aspiration with sclerotherapy demonstrated disappointing results due to multiple lesions. Because the cysts in PLD mostly supplied from hepatic arteries but portal veins, transcatheter arterial embolization (TAE) artery branches that supply major can...
Summary Purpose The objective of this study was to compare the clarity magnetic resonance lymphography ( MRL ) images thoracic duct TD obtained from subjects following an overnight fast with those same after ingestion a high fat meal. Methods Nineteen healthy volunteers were included in study. acquired on 3·0T MRI system imaging sequence cholangiopancreatography. and 3–4 h Images displayed maximum intensity projection format degree visualization evaluated using scoring system. Results mean...
Abdominal aortic occlusion (AAO) occurs frequently and causes ischemia/reperfusion (I/R) injury to distant organs. In this study, we aimed investigate whether AAO induced I/R subsequent damage in cardiac neurologic tissue. We also the how length of ischemic time influences reactive oxygen species (ROS) production inflammatory marker levels heart, brain, serum.Sixty male C57BL/6 mice were used study. The randomly divided into either sham group or group. was further subdivided 1-4 hr groups...
The present study analyzed the safety and efficacy of superselective arterial embolization (SAE) combined with radiofrequency ablation (RFA) to treat renal angiomyolipoma (RAML).This retrospective included clinical data 6 patients RAML treated between March 2016 October 2017. All underwent RFA treatment immediately after SAE guided by angio-computed tomography (angio-CT). tumor size, function complications, time recurrence were compared before treatment.The success rate + technique was 100%,...