A5100703284- Nanoplatforms for cancer theranostics
- Nanoparticles: synthesis and applications
- Nanoparticle-Based Drug Delivery
- Burn Injury Management and Outcomes
- Extracellular vesicles in disease
- Advanced biosensing and bioanalysis techniques
- Luminescence and Fluorescent Materials
- Wound Healing and Treatments
- Graphene and Nanomaterials Applications
- Medical and Biological Ozone Research
Zhejiang University
2017-2021
Hangzhou Xixi hospital
2019
Second Affiliated Hospital of Zhejiang University
2017
Chronic nonhealing wounds have imposed serious challenges in the clinical practice, especially for patients infected with multidrug-resistant microbes. Herein, we developed an ultrasmall copper sulfide (covellite) nanodots (CuS NDs) based dual functional nanosystem to cure bacteria-infected chronic wound. The could eradicate bacteria and expedite wound healing simultaneously owing photothermal effect remote control of copper-ion release. antibacterial results indicated that combination...
Abstract Renal‐clearable nanoparticles have made it possible to overcome the toxicity by nonspecific accumulation in healthy tissues/organs due their highly efficient clearance characteristics. However, tumor uptake is relatively low short blood circulation time and rapid body elimination. Here, this problem addressed developing renal‐clearable controlled coating of sub‐6 nm CuS nanodots (CuSNDs) on doxorubicin ladened mesoporous silica (pore size ≈6 nm) for multimodal application. High...
With the ever-growing threat of bacterial infections, especially for multidrug-resistant microbial development highly effective treatment modalities to inhibit infections is challenging. Although silver nanoparticles have been intensively applied as antimicrobial agent decades, therapeutic efficacy toward bacteria still unsatisfactory. Here, we show that near-infrared (NIR) laser-excited triangular (Tri-Ag) can efficiently kill Gram-negative Escherichia coli and Gram-positive Staphylococcus...
During the past two decades, aggregation-induced emission luminogens (AIEgens) have been intensively exploited for biological and biomedical applications. Although a series of investigations performed in non-primate animal models, there is few pilot studies non-human primate strongly hindering clinical translation AIE (AIEgens). Herein, we present systemic multifaceted demonstration an optical imaging-guided surgical operation via AIEgens from small animals (e.g., mice rabbits) to rhesus...
We report a versatile nanoplatform with size tunability, pH-responsiveness, active targeting and radio-/chemotherapeutic features as an efficient tool for tumor therapy.