A5100437346- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Facial Rejuvenation and Surgery Techniques
- Retinal and Macular Surgery
- Intraocular Surgery and Lenses
- Liver physiology and pathology
- Traumatic Ocular and Foreign Body Injuries
- MRI in cancer diagnosis
- Facial Nerve Paralysis Treatment and Research
- Liver Disease and Transplantation
- Renal cell carcinoma treatment
- Facial Trauma and Fracture Management
- Cancer, Hypoxia, and Metabolism
- Oral and Maxillofacial Pathology
- Organ Transplantation Techniques and Outcomes
- Hepatitis B Virus Studies
- Pancreatic and Hepatic Oncology Research
- Advanced MRI Techniques and Applications
- Immune Cell Function and Interaction
- Glaucoma and retinal disorders
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Healthcare and Venom Research
- Salivary Gland Tumors Diagnosis and Treatment
- Mathematical Biology Tumor Growth
Cedars-Sinai Medical Center
2018-2025
Shenyang Agricultural University
2023-2024
Ministry of Agriculture and Rural Affairs
2023-2024
Hubei University of Science and Technology
2024
Baoji City Central Hospital
2024
Shanghai Jiao Tong University
2012-2024
Ningxia Medical University
2014-2024
Ningxia Medical University General Hospital
2024
Union Hospital
2012-2023
Huazhong University of Science and Technology
2011-2023
The process of diabetic wound healing was influenced by the excessive proliferation reactive oxygen species (ROS). Therefore, in wounds, it crucial to removing ROS. This study designed composited nanoparticles: KBP, consisted Konjac glucomannan, bovine serum albumin, and Prussian blue. Then they were embedded glucomannan hydroxypropyl trimethylammonium chloride chitosan composite hydrogel (KH), KBP@KH finally achieved excellent efficacy healing. vitro vivo experiments demonstrated that KPB...
Purpose Genetic polymorphisms of organic cation transporter 2 (OCT2) have been recently described, but their genotype–phenotype relationship in humans is unknown. We performed this study to (i) characterize genetic variations the OCT2 gene Chinese population and (ii) investigate potential functional significance using metformin (an substrate) alone or presence its transport inhibitor (cimetidine). Method Direct sequencing all exons surrounding introns was genomic DNA from 112 healthy...
It has been reported that tetraspanin CD151 acts as a promoter of metastasis in several tumors and plays an important role c-Met/hepatocyte growth factor signaling. However, the alone coexpression CD151/c-Met hepatocellular carcinoma (HCC) remains unclear. We found expression was positively related to metastatic potential HCC cell lines, modified cells with CD151(high) showed higher secretion matrix metalloproteinase 9 aggressiveness vitro ability vivo. Furthermore, patients vascular...
To evaluate the diagnostic performance of three-dimensional ( 3D ) quantitative enhancement-based and diffusion-weighted volumetric magnetic resonance (MR) imaging assessment hepatocellular carcinoma HCC lesions in determining extent pathologic tumor necrosis after transarterial chemoembolization TACE ).This institutional review board-approved retrospective study included 17 patients with who underwent before surgery. Semiautomatic segmentation target was performed at last MR examination...
Nonalcoholic fatty liver disease (NAFLD) enhances the growth and recurrence of colorectal cancer (CRC) metastasis. With rising prevalence NAFLD, a better understanding molecular mechanism underlying NAFLD‐associated metastasis is crucial. Tumor‐associated macrophages (TAMs) constitute large portion tumor microenvironment that promotes growth. NOD‐like receptor C4 (NLRC4), component an inflammasome complex, plays role in macrophage activation interleukin (IL)‐1β processing. We aimed to...
Abstract Background Special AT ‐rich binding protein‐1 ( SATB 1) reprograms chromatin organization and transcription profiles to promote tumour growth metastasis. Aims This study aimed confirm the effects of 1 on metastasis liver cancer its specific regulation mechanism. Methods expression was evaluated in human hepatoma tissue, adjacent noncancerous tissue seven kinds cell lines. Cell cycle, proliferation, apoptosis eptithelial‐mesenchymal transition EMT ) investigated after enhanced or...
Diverse bacteria contain DNA with sulfur incorporated stereo-specifically into their backbone at specific sequences (phosphorothioation). We found that in vitro oxidation of phosphorothioate (PT) by hydrogen peroxide (H(2)O(2)) or peracetic acid has two possible outcomes: cleavage removal resulting restoration normal backbone. The physiological relevance this redox reaction was investigated challenging PT hosting Salmonella enterica cells using H(2)O(2). phosphorothioation to correlate...
Abstract Colorectal cancer (CRC) liver metastasis is a significant clinical problem for which better therapies are urgently needed. Tumor-associated macrophage, major cell population in the tumor microenvironment, known contributor to primary progression and metastasis. Here, we found TAM recruitment M2 polarization were increased hepatic metastatic lesion compared with site of human CRC tissues. Moreover, Pearson correlation analysis showed that closely correlated elevated TCF4 expression...
Steatotic liver enhances metastasis of colorectal cancer, but this process is not fully understood. induced by a high-fat diet (HFD) increases cancer-associated fibroblast (CAF) infiltration and collagen hyaluronic acid (HA) production. We investigated the role HA synthase 2 (HAS2) in fibrotic tumor microenvironment steatotic using Has2ΔHSC mice, which Has2 deleted from hepatic stellate cells. mice had reduced steatotoic liver-associated metastatic growth MC38 cancer cells, deposition, CAF...
To quantify the reduction of radiation liver cancer patients are exposed to during transarterial chemoembolization (TACE), while maintaining diagnostic image quality, using a new C-arm imaging platform.In this prospective, HIPAA-compliant, IRB-approved, two-arm trial, 78 consecutive with primary or secondary were treated TACE on platform before and after an upgrade incorporating optimized acquisition parameters advanced real-time processing algorithms. Dose area product (DAP) time each...
To determine whether volumetric changes of enhancement as seen on contrast-enhanced magnetic resonance (MR) imaging can help assess early tumor response and predict survival in patients with metastatic uveal melanoma after one session transarterial chemoembolization (TACE).Fifteen 59 lesions who underwent MR before 3 to 4 weeks the first TACE were retrospectively included. analysis evaluated signal intensities, World Health Organization (WHO), Response Evaluation Criteria Solid Tumors...
IL27 has been reported to play dual roles in cancer; however, its effects on the tumor microenvironment (TME), immunotherapy, and prognosis melanoma remain largely unclear. This study was aimed uncover of TME, immunotherapy patients with melanoma.RNA-seq data, drug sensitivity clinical data were obtained from TCGA, GEO, CCLE, CTRP. Log-rank test used determine survival value IL27. Univariate multivariate Cox regression analyses employed independent predictors outcomes. DAVID GSEA perform...
To investigate potential risk factors for development of proliferative vitreoretinopathy (PVR) post trauma and evaluate the effect PVR on anatomical visual outcomes in injured eyes.Overall, 179 eyes with 221 without after injury were selected from database Eye Injury Vitrectomy Study, a multicenter cohort study launched 1997. Multivariate logistic regression was used to ascertain independent influence outcomes.An interval vitrectomy more than 28 days (odds ratio, 139.25; confidence interval,...
Aim: Colorectal cancer (CRC) is a major malignancy in China, which the critical risk of people health. Many natural herbs extracts have been found to exhibit good therapeutic effect on CRC. Our previous study that grape seed procyanidins B2 (PB2) would induce CRC cell death. However, molecular mechanism underlying its anti-tumor remains unclear. Thereby, this aimed investigate PB2 Methods: CCK-8, western blotting, flow cytometry, qRT-PCR and animal were used current study. Results: The vitro...
Effective therapies for alcohol-associated liver disease (ALD) are limited; therefore, the discovery of new therapeutic agents is greatly warranted. Toll-like receptor 7 (TLR7) a pattern recognition single-stranded RNA, and its activation prevents fibrosis. We examined intestinal damage in Tlr7-/- mice to determine role TLR7 ALD pathogenesis. In an alcoholic hepatitis (AH) mouse model, hepatic steatosis, injury, inflammation were induced by chronic binge ethanol feeding mice, Tlr7 deficiency...
Investigate possible risk factors of no light perception (NLP) after open-globe injury. Explore whether these are predictors for an unfavorable visual outcome.This case-control study matched 72 eyes with NLP according to type and zone injury 2 controls per case or better vision. Cases were selected from the Eye Injury Vitrectomy Study database. All injured in underwent surgical intervention.Ciliary body damage (odds ratio = 2.94), closed funnel retinal detachment 2.43), choroidal 2.80)...
Objective To evaluate the effectiveness and safety of prostatic arterial embolization as a primary treatment for patients with lower urinary tract symptoms result large benign hyperplasia. Methods A total 64 prostates >80 mL were included in study. Prostatic was carried out using combination 50‐µm 100‐µm particles. Clinical follow up International Prostate Symptom Score, quality life, peak flow, postvoid residual volume, Index Erectile Function Short Form, prostate‐specific antigen,...
Fatness traits in animals are important for their growth, meat quality, reproductive performance, and immunity. The liver is the principal organ of regulation lipid metabolism, this study used massive parallelized high-throughput sequencing technologies to determine porcine tissue transcriptome architecture two full-sibling Songliao black pigs harboring extremely different phenotypes backfat thickness.The total number reads produced each sample was region 53 million, 8,226 novel transcripts...
Purpose To assess the visibility of radiopaque microspheres during transarterial embolization (TAE) in VX2 rabbit liver tumor model by using multimodality imaging, including single-snapshot radiography, cone-beam computed tomography (CT), multidetector CT, and micro-CT. Materials Methods The study was approved institutional animal care use committee. Fifteen VX2-tumor-bearing rabbits were assigned to three groups depending on type embolic agent injected: 70-150-μm saline (radiopaque...