A5018026841- Gut microbiota and health
- Diet and metabolism studies
- Inflammatory Bowel Disease
- Microscopic Colitis
- Clostridium difficile and Clostridium perfringens research
- Dietary Effects on Health
- Probiotics and Fermented Foods
- Adipose Tissue and Metabolism
- Helicobacter pylori-related gastroenterology studies
- Muscle metabolism and nutrition
- Nutrition, Genetics, and Disease
- Clinical Nutrition and Gastroenterology
- Metabolism, Diabetes, and Cancer
- Gastrointestinal motility and disorders
- Metabolomics and Mass Spectrometry Studies
- Kawasaki Disease and Coronary Complications
- Diabetes and associated disorders
- Nutritional Studies and Diet
- Inflammasome and immune disorders
- Digestive system and related health
- Tryptophan and brain disorders
- Child Nutrition and Water Access
- Autoimmune and Inflammatory Disorders
- Molecular Biology Techniques and Applications
- Microbial Metabolism and Applications
Cedars-Sinai Medical Center
2016-2025
University of California, Los Angeles
2018-2022
Jackson and Tull (United States)
2022
Joslin Diabetes Center
2013-2016
Harvard University
2013-2016
University of Chicago
2010-2013
Harvard University Press
2013
University of Illinois Urbana-Champaign
2007-2010
University of Illinois Chicago
2010
Institute of Nutrition, Metabolism and Diabetes
2010
Breast cancer is the most prevalent in American women. Dietary factors are thought to have a strong influence on breast incidence. This study utilized meal-feeding protocol with female Sprague-Dawley rats evaluate effects of two ratios carbohydrate:protein promotion and early progression tissue carcinomas. Mammary tumors were induced by N-methyl-N-nitrosourea (MNU) at 52 d age. Post-induction, animals assigned consume either low protein high carbohydrate diet (LPHC; 15% 60% energy,...
The composite human gut microbiomes of Western populations have changed over the past century, brought on by new environmental triggers that often a negative impact health. Diets high in saturated fats and refined sugars low fiber are leading candidates for these events triggering increased prevalence immune-mediated diseases like inflammatory bowel disease (IBD). Our studies shown consumption ‘Western' diet (milk-derived) fat (MF) or n-6 polyunsaturated (safflower oil) similar effects...
Interactions of diet, gut microbiota, and host genetics play important roles in the development obesity insulin resistance. Here, we have investigated molecular links between resistance, glucose metabolism 3 inbred mouse strains with differing susceptibilities to metabolic syndrome using diet antibiotic treatment. Antibiotic treatment altered intestinal decreased tissue inflammation, improved signaling basal stimulated states, obesity- diabetes-prone C57BL/6J mice on a high-fat (HFD). Many...
Growing evidence shows that dietary factors can dramatically alter the gut microbiome in ways contribute to metabolic disturbance and progression of obesity. In this regard, mesenteric adipose tissue has been implicated mediating these processes through elaboration proinflammatory adipokines. study, we examined relationship events by determining effects fat content source on microbiota, as well adipokine profiles peripheral adipocytes.Adult male C57Bl/6 mice were fed milk fat-based,...
Many colonic mucosal genes that are highly regulated by microbial signals differentially expressed along the rostral-caudal axis. This would suggest differences in regional microbiota exist, particularly mucosa-associated microbes less likely to be transient. We therefore explored this possibility examining bacterial populations associated with normal proximal and distal mucosa context of host Toll-like receptors (TLR) expression C57BL/6J mice housed specific pathogen-free (SPF) germ-free...
Abstract For more than a century, the prenatal environment was considered sterile. Over last few years, findings obtained with next-generation sequencing approaches from samples of placenta, amniotic fluid, meconium, and even fetal tissues have challenged dogma sterile womb, additional reports emerged that used culture, microscopy, quantitative PCR to support presence low-biomass microbial community at sites. Given substantial implications exposure microbes for development health host,...
Unique gut microbiota compositions have been associated with inflammatory diseases, but identifying bacterial functions linked to immune activation in humans remains challenging. Translocation of pathogens from mucosal surfaces into peripheral tissues can elicit activation, although whether and which commensal bacteria translocate diseases is difficult assess. We report that a subset constituents across the barrier mice are heightened systemic immunoglobulin G (IgG) responses. present...
The common food additive carrageenan is a known activator of inflammation in mammalian tissues and stimulates both the canonical noncanonical pathways NF- κ B activation. Exposure to low concentrations (10 μ g/mL water supply) has produced glucose intolerance, insulin resistance, impaired signaling C57BL/6 mice. B-cell leukemia/lymphoma 10 (Bcl10) mediator inflammatory signals from Toll-like receptor (TLR) 4 myeloid epithelial cells. Since TLR4 pathway activated diabetes by carrageenan, we...
Estrogen and progesterone have been extensively studied in the mammary gland, but molecular effects of androgen remain largely unexplored. Transgender men are recorded as female at birth identify male may undergo gender-affirming therapy to align their physical characteristics gender identity. Here we perform single-cell-resolution transcriptome, chromatin, spatial profiling breast tissues from transgender following therapy. We find canonical receptor gene targets upregulated cells...
Ingestion of fermented foods impacts human immune function, yet the bioactive food components underlying these effects are not understood. Here, we interrogated whether bioactivity relates to microbial metabolites derived from aromatic amino acids, termed aryl-lactates. Using targeted metabolomics, established presence aryl-lactates in commercially available foods. After pinpointing food-associated lactic acid bacteria that produce high levels aryl-lactates, identified fermentation...
BACKGROUND: Alterations in the intestinal microbiota contribute to pathogenesis of various cardiovascular disorders, but how they affect development Kawasaki disease, an acute pediatric vasculitis, remains unclear. Here, using a murine model mimicking disease we assessed contribution vascular inflammation. METHODS AND RESULTS: We report that depleting gut reduces inflammation vasculitis. The lesions was associated with alterations composition and, notably, decreased abundance Akkermansia...