A5045113605- Gut microbiota and health
- Clostridium difficile and Clostridium perfringens research
- Neurobiology and Insect Physiology Research
- Plant Molecular Biology Research
- Gastrointestinal motility and disorders
- Microscopic Colitis
- CRISPR and Genetic Engineering
- Insect and Arachnid Ecology and Behavior
- Invertebrate Immune Response Mechanisms
- Probiotics and Fermented Foods
- IL-33, ST2, and ILC Pathways
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Machine Learning in Bioinformatics
- Advanced biosensing and bioanalysis techniques
- Immune Cell Function and Interaction
- Microbial Metabolism and Applications
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- RNA and protein synthesis mechanisms
- Insect Resistance and Genetics
National Institute of Allergy and Infectious Diseases
2018-2022
National Institutes of Health
2018-2022
National Cancer Institute
2022
Phillips Exeter Academy
2016-2019
Mayo Clinic in Arizona
2018
Increased amino acids in the dysbiotic gut influences susceptibility to Clostridioides difficile infection mice and humans.
PURPOSE Metastatic breast cancer (mBrCa) is most often an incurable disease with only modest responses to available immunotherapies. This study investigates the immunogenicity of somatic mutations in and explores therapeutic efficacy a pilot trial mutation-reactive tumor-infiltrating lymphocytes (TILs) patients metastatic disease. PATIENTS AND METHODS Forty-two mBrCa refractory previous lines treatment underwent surgical resection lesion(s), isolation TIL cultures, identification exomic...
Unique gut microbiota compositions have been associated with inflammatory diseases, but identifying bacterial functions linked to immune activation in humans remains challenging. Translocation of pathogens from mucosal surfaces into peripheral tissues can elicit activation, although whether and which commensal bacteria translocate diseases is difficult assess. We report that a subset constituents across the barrier mice are heightened systemic immunoglobulin G (IgG) responses. present...
Abstract Novel binary gene expression tools like the LexA-LexAop system could powerfully enhance studies of metabolism, development, and neurobiology in Drosophila. However, specific LexA drivers for neuroendocrine cells many other developmentally relevant systems remain limited. In a unique high school biology course, we generated LexA-based enhancer trap collection by transposon mobilization. The initial provides source novel elements that permit targeted corpora cardiaca, central...
Binary expression systems like the LexA-LexAop system provide a powerful experimental tool kit to study gene and tissue function in developmental biology, neurobiology, physiology. However, number of well-defined LexA enhancer trap insertions remains limited. In this study, we present molecular characterization initial analysis nearly 100 novel StanEx traps, derived from
Abstract While the microbiota has been associated with diseases states, how specific alterations in composition, function, or localization contribute to pathologies remains unclear. The ability of defined microbes translocate linked including inflammatory bowel disease (IBD) and was shown promote responses immune checkpoint therapy. However, scalable unbiased tools uncover enhanced are limited. Herein, we developed an approach utilize systemic IgG unbiased, culture-independent,...
Abstract Binary expression systems like the LexA-LexAop system provide a powerful experimental tool kit to study gene and tissue function in developmental biology, neurobiology physiology. However, number of well-defined LexA enhancer trap insertions remains limited. In this study, we present molecular characterization initial analysis nearly 100 novel StanEx traps, derived from StonEx 1 index line. This includes 76 into novel, distinct loci not previously associated with traps or targeted...