A5002142919- Neurobiology and Insect Physiology Research
- Invertebrate Immune Response Mechanisms
- CRISPR and Genetic Engineering
- Genetics, Aging, and Longevity in Model Organisms
Palo Alto University
2016
Stanford University
2014
Insulin is a major regulator of metabolism in metazoans, including the fruit fly Drosophila melanogaster. Genome-wide association studies (GWAS) suggest genetic basis for reductions both insulin sensitivity and secretion, phenotypes commonly observed humans with type 2 diabetes mellitus (T2DM). To identify molecular functions genes linked to T2DM risk, we developed tool measure insulin-like peptide (Ilp2) levels Drosophila, model organism superb experimental genetics. Our system permitted...
Abstract Novel binary gene expression tools like the LexA-LexAop system could powerfully enhance studies of metabolism, development, and neurobiology in Drosophila. However, specific LexA drivers for neuroendocrine cells many other developmentally relevant systems remain limited. In a unique high school biology course, we generated LexA-based enhancer trap collection by transposon mobilization. The initial provides source novel elements that permit targeted corpora cardiaca, central...