A5032015753- Epigenetics and DNA Methylation
- Nuclear Receptors and Signaling
- RNA modifications and cancer
- Cancer-related gene regulation
- Cancer Genomics and Diagnostics
- Single-cell and spatial transcriptomics
- Immune Cell Function and Interaction
- Ginkgo biloba and Cashew Applications
- Pregnancy and preeclampsia studies
- Plant Molecular Biology Research
- MicroRNA in disease regulation
- Prenatal Screening and Diagnostics
- Ovarian cancer diagnosis and treatment
- Acute Lymphoblastic Leukemia research
- Neurobiology and Insect Physiology Research
- Ferroptosis and cancer prognosis
- Space Science and Extraterrestrial Life
- Histone Deacetylase Inhibitors Research
- Monoclonal and Polyclonal Antibodies Research
- Spaceflight effects on biology
- Angiogenesis and VEGF in Cancer
- PARP inhibition in cancer therapy
- Cell Adhesion Molecules Research
- Space Exploration and Technology
- Insect Resistance and Genetics
University of Michigan
2020-2023
Prevention Institute
2021-2023
Texas A&M University
2020-2023
Moores Cancer Center
2023
Massachusetts Institute of Technology
2021
Mitchell Institute
2020
Phillips Exeter Academy
2019
Vanderbilt University
2018
Abstract Inactivation of tumor-infiltrating lymphocytes (TIL) is one the mechanisms mitigating antitumor immunity during tumor onset and progression. Epigenetic abnormalities are regarded as a major culprit contributing to dysfunction TILs within microenvironments. In this study, we used murine model melanoma discover that Tet2 inactivation significantly enhances activity with an efficacy comparable immune checkpoint inhibition imposed by anti-PD-L1 treatment. Single-cell RNA-sequencing...
Binary expression systems like the LexA-LexAop system provide a powerful experimental tool kit to study gene and tissue function in developmental biology, neurobiology, physiology. However, number of well-defined LexA enhancer trap insertions remains limited. In this study, we present molecular characterization initial analysis nearly 100 novel StanEx traps, derived from
Placental dysfunction is implicated in many pregnancy complications, including preeclampsia and preterm birth (PTB). While both these syndromes are influenced by environmental risk factors, they also have a substantial genetic component that not well understood. Precisely controlled gene expression during development crucial to proper placental function often mediated through regulatory enhancers. However, we lack accurate maps of enhancer activity due the challenges assaying placenta...
<div>Abstract<p>Inactivation of tumor-infiltrating lymphocytes (TIL) is one the mechanisms mitigating antitumor immunity during tumor onset and progression. Epigenetic abnormalities are regarded as a major culprit contributing to dysfunction TILs within microenvironments. In this study, we used murine model melanoma discover that Tet2 inactivation significantly enhances activity with an efficacy comparable immune checkpoint inhibition imposed by anti-PD-L1 treatment. Single-cell...
<div>Abstract<p>Inactivation of tumor-infiltrating lymphocytes (TIL) is one the mechanisms mitigating antitumor immunity during tumor onset and progression. Epigenetic abnormalities are regarded as a major culprit contributing to dysfunction TILs within microenvironments. In this study, we used murine model melanoma discover that Tet2 inactivation significantly enhances activity with an efficacy comparable immune checkpoint inhibition imposed by anti-PD-L1 treatment. Single-cell...
<p>Differentially expressed genes</p>
<p>Supplemental Figures 1-5.</p>
<p>NGS data statistics</p>
<p>Supplemental Figures 1-5.</p>
<p>Cluster marker genes of Single cell RNA-seq</p>
<p>NGS data statistics</p>
<p>Cluster marker genes of Single cell RNA-seq</p>
<p>Supplementary info</p>
<p>Differentially expressed genes</p>
<p>Supplementary info</p>
<p>Differentially accessible regions</p>
<p>Differentially accessible regions</p>
Abstract High-grade serous ovarian cancer (HGSOC) is deadliest of gynecological malignancies. Ovarian tumor cells can directly spread throughout the peritoneal space as single that grow into tumorspheres concomitant with generation malignant ascites contains growth factors and extracellular matrix (ECM) proteins. Greater than 70% advanced stage HGSOC patients exhibit gains or amplifications for Focal Adhesion Kinase (FAK) gene, a tyrosine kinase activated by ECM In other solid tumors,...
ABSTRACT Placental dysfunction is implicated in many pregnancy complications, including preeclampsia and preterm birth (PTB). While both these syndromes are influenced by environmental risk factors, they also have a substantial genetic component that not well understood. Precisely controlled gene expression during development crucial to proper placental function often mediated through regulatory enhancers. However, we lack accurate maps of enhancer activity due the challenges assaying...
Abstract Binary expression systems like the LexA-LexAop system provide a powerful experimental tool kit to study gene and tissue function in developmental biology, neurobiology physiology. However, number of well-defined LexA enhancer trap insertions remains limited. In this study, we present molecular characterization initial analysis nearly 100 novel StanEx traps, derived from StonEx 1 index line. This includes 76 into novel, distinct loci not previously associated with traps or targeted...
Abstract Inactivation of tumor infiltrating lymphocytes (TILs) is one the mechanisms mitigating anti-tumor immunity during onset and progression. Epigenetic abnormalities are regarded as a major culprit contributing to dysfunction TILs within microenvironments. In this study, we used murine model melanoma discover that Tet2 inactivation significantly enhances activity TILs, with efficacy comparable immune checkpoint inhibition imposed by anti-PD-L1 treatment. Single-cell RNA-seq analysis...