A5040434633- Health Sciences Research and Education
- Drug Transport and Resistance Mechanisms
- Innovations in Medical Education
- Cytokine Signaling Pathways and Interactions
- PI3K/AKT/mTOR signaling in cancer
- Pharmacogenetics and Drug Metabolism
- Library Science and Information Literacy
- Pharmacological Effects and Toxicity Studies
- Cerebrovascular and Carotid Artery Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Cancer, Hypoxia, and Metabolism
- Oral and Maxillofacial Pathology
- Monoclonal and Polyclonal Antibodies Research
- Medical Imaging Techniques and Applications
- Radiology practices and education
- Metabolism and Genetic Disorders
- Research Data Management Practices
- Platelet Disorders and Treatments
- Big Data Technologies and Applications
- Machine Learning in Bioinformatics
- interferon and immune responses
- Data Quality and Management
- Mass Spectrometry Techniques and Applications
- Hedgehog Signaling Pathway Studies
- Pharmacovigilance and Adverse Drug Reactions
Jiangsu University
2023
First People's Hospital of Kunshan
2023
Hainan Normal University
2021-2022
Hainan University
2021-2022
Neijiang Normal University
2021
University of Electronic Science and Technology of China
2021
Bristol-Myers Squibb (United States)
2015-2020
Yangzhou University
2020
University of Iowa
2012-2017
State Library of Iowa
2016-2017
Perturbation of organic anion transporter (OAT) 1- and OAT3-mediated transport can alter the exposure, efficacy, safety drugs. Although there have been reports endogenous biomarkers for OAT1/3, none these all characteristics required a clinical useful biomarker. Cynomolgus monkeys were treated with intravenous probenecid (PROB) at dose 40 mg/kg in this study. As expected, PROB increased area under plasma concentration-time curve (AUC) coadministered furosemide, known substrate OAT1 OAT3, by...
The covalent conjugation of polyethylene glycol (PEG, typical MW > 10k) to therapeutic peptides and proteins is a well-established approach improve their pharmacokinetic properties diminish the potential for immunogenicity. Even though PEG generally considered biologically inert safe in animals humans, slow clearance large PEGs raises concerns about adverse effects resulting from accumulation tissues following chronic administration, particularly central nervous system. key information...
JAK2 kinase inhibitors are a promising new class of agents for the treatment myeloproliferative neoplasms and have potential other diseases possessing deregulated JAK2-STAT pathway. X-ray structure ADME guided refinement C-4 heterocycles to address metabolic liability present in dialkylthiazole 1 led discovery clinical candidate, BMS-911543 (11), with excellent kinome selectivity, vivo PD activity, safety profile.
FcγRIIB functions to suppress the activation of immune cells. A single-nucleotide polymorphism in transmembrane (TM) domain FcγRIIB, FcγRIIB-T232, is associated with lupus. In this study, we investigated pathogenic mechanism FcγRIIB-T232 at both functional and structural levels. Our results showed that exhibited significantly reduced lateral mobility compared FcγRIIB-I232 was less enriched into microclusters complexes (ICs) after stimulation. However, if sufficient responding time given for...
As the central hub of metabolism machinery, mammalian target rapamycin complex 2 (mTORC2) has been well studied in lymphocytes. an obligatory component mTORC2, role Rictor T cells is established. However, B still remains elusive. involved cell development, especially peripheral development. on receptor (BCR) signaling as underlying cellular and molecular mechanism unknown. This study used cell–specfic knockout (KO) mice to investigate how regulates BCR signaling. We found that key positive...
Hepatocellular carcinoma (HCC) is a malignancy with high incidence and fatality rate worldwide. Hepatitis B virus (HBV) infection one of the most important risk factors for its occurrence development. Early detection HBV-associated HCC (HBV-HCC) can improve clinical decision-making patient outcomes. Biomarkers are extremely helpful, not only early diagnosis, but also development therapeutics. MicroRNAs (miRNAs), subset non-coding RNAs approximately 22 nucleotides in length, have increasingly...
Unbound plasma concentrations may not reflect those in target tissues, and there is a need for methods to predict tissue partitioning. Here, we investigate the unbound liver partitioning (<i>Kp</i><sub>u,u</sub>) of rosuvastatin, substrate hepatic organic anion transporting peptides, cynomolgus monkeys compare it with that determined using hepatocytes vitro. Rosuvastatin (3 mg/kg) was administered orally (by ultrasound-guided biopsy) collected over time. Uptake into monkey evaluated up...
<p>This data management report was commissioned by the University of Iowa Libraries with intention performing a survey campus landscape and identifying gaps in services. The first stage collection consisted conducted during summer 2012 to which 784 responses were received. second phase approximately 40 in-depth interviews individuals from completed 2013. Findings are presented as challenges opportunities within five broad areas management: planning, storage, organization analysis,...
Despite a recent expansion in the recognition of potential utility coproporphyrin (CP) as an endogenous biomarker organic anion-transporting polypeptide (OATP) 1B activity, there have been few detailed studies CP's pharmacokinetic behavior and overall poor understanding its fate from tissues excretion. Here, we describe pharmacokinetics octadeuterium-labeled I (CPI-d8) cynomolgus monkeys following oral intravenous administration. CPI-d8 has half-life bioavailability 7.6 hours 3.2%,...
To investigate the influence of hypertension on large artery elasticity and microstructure ascending aortic media in patients with coronary disease (CAD), association between arterial compliance composition aorta.60 CAD who underwent bypass graft surgery were divided into two groups: 30 a group non-hypertension group. Carotid-femoral pulse wave velocity (cfPWV) was measured by an automatic device (Complior, Artech, France). The severity atherosclerosis assessed after selective angiography...
In the present study, total membrane proteins from tumor cell lines including HepG2, Hep3B2, H226, Ovcar3 and N87 were extracted digested with γLysC trypsin. The resulting peptide lysate pre-fractionated subjected to untargeted quantitative proteomics analysis using a high resolution mass spectrometer. spectra processed by MaxQuant protein abundances estimated peak area (TPA) method. A of 6037 identified, resulted in identification 2647 proteins. Of those, antigens absorption, metabolism,...