A5048967934- Asthma and respiratory diseases
- Inhalation and Respiratory Drug Delivery
- Respiratory viral infections research
- Pediatric health and respiratory diseases
- T-cell and B-cell Immunology
- Cancer Cells and Metastasis
- Congenital Heart Disease Studies
- Chromatin Remodeling and Cancer
- Neonatal Respiratory Health Research
- IL-33, ST2, and ILC Pathways
- PI3K/AKT/mTOR signaling in cancer
- Pneumonia and Respiratory Infections
- Pulmonary Hypertension Research and Treatments
- Congenital Diaphragmatic Hernia Studies
- Viral gastroenteritis research and epidemiology
- Virus-based gene therapy research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Platelet Disorders and Treatments
- Mechanisms of cancer metastasis
Chongqing Medical University
2013-2022
Children's Hospital of Chongqing Medical University
2013-2022
China International Science and Technology Cooperation
2018-2021
As the central hub of metabolism machinery, mammalian target rapamycin complex 2 (mTORC2) has been well studied in lymphocytes. an obligatory component mTORC2, role Rictor T cells is established. However, B still remains elusive. involved cell development, especially peripheral development. on receptor (BCR) signaling as underlying cellular and molecular mechanism unknown. This study used cell–specfic knockout (KO) mice to investigate how regulates BCR signaling. We found that key positive...
Background/Aims: Previous studies have shown that lipopolysaccharide (LPS) exposure may a protective effect on asthma by reducing airway hyper-responsiveness, inflammation and serum IgE levels. However, there are few investigating the of LPS mucous secretion in asthma. In this study, we evaluate relationship between pre-treatment infant mice mucus hypersecretion an OVA (ovalbumin)-induced model, further explore mechanisms behind effect. Methods: Mice were pre-treated with intranasal...
Pulmonary hypertension (PH) associated with congenital heart disease (CHD) is the most common type of PH in pediatric patients. The airway microbiome profile CHD-PH patients remains rarely studied. A total 158 children were recruited for collection oropharyngeal swabs to sequence 16S ribosomal RNA (16S rRNA) V3-V4 region respiratory microbiome, establish a correlation between these bacterial groups and echocardiography indicators Bacterial α- β-diversity indicated significantly lower...
What is the central question of this study? The aim was to investigate function brahma-related gene-1 (BRG1) in airway remodelling epithelial-to-mesenchymal transition (EMT) asthma and identify transcription factor BRG1 that binds protomer E-cadherin. main finding its importance? This study highlighted an important molecular mechanism involving chromatin played a crucial role EMT demonstrated ZEB1 key recruiting BRG1. might offer new insights into gene-based therapy for...
To study the consistency between nasopharyngeal aspirates (NPA) and bronchoalveolar lavage fluid (BALF) in pathogen detection children with pneumonia.A retrospective analysis was performed on data of pathogens detected 533 pneumonia from February 2017 to March 2020. The paired McNemar's test used compare difference NPA BALF groups. Kappa coefficient analyze two groups.NPA had a sensitivity 28%, specificity 74%, positive predictive value 14%, negative 91% detecting bacteria, 0.013 suggested...