A5083968172- Ion channel regulation and function
- Neuroscience and Neuropharmacology Research
- Cancer-related molecular mechanisms research
- Neuroscience and Neural Engineering
- Photoreceptor and optogenetics research
- MicroRNA in disease regulation
- Heat shock proteins research
- Galectins and Cancer Biology
- Endoplasmic Reticulum Stress and Disease
- Cancer, Lipids, and Metabolism
- Ion Channels and Receptors
- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- Protein Structure and Dynamics
- Connexins and lens biology
University of South China
2022-2024
Tsinghua University
2012-2016
Abstract Atherosclerosis is a leading cause of cardiovascular diseases (CVDs), often resulting in major adverse events (MACEs), such as myocardial infarction and stroke due to the rupture or erosion vulnerable plaques. Ferroptosis, an iron‐dependent form cell death, has been implicated development atherosclerosis. Despite its involvement CVDs, specific role ferroptosis atherosclerotic plaque stability remains unclear. In this study, we confirmed presence unstable plaques demonstrated that...
FcγRIIB functions to suppress the activation of immune cells. A single-nucleotide polymorphism in transmembrane (TM) domain FcγRIIB, FcγRIIB-T232, is associated with lupus. In this study, we investigated pathogenic mechanism FcγRIIB-T232 at both functional and structural levels. Our results showed that exhibited significantly reduced lateral mobility compared FcγRIIB-I232 was less enriched into microclusters complexes (ICs) after stimulation. However, if sufficient responding time given for...
Voltage-gated sodium (Nav) channels are critical in the generation and transmission of neuronal signals mammals. The crystal structures several prokaryotic Nav determined recent years inspire mechanistic studies on their selection upon permeable cations (especially between Na+ K+ ions), a property that is proposed to be mainly by residues selectivity filter. However, mechanism cation mammalian lacks direct explanation at atomic level due difference amino acid sequences homologues, especially...