Abstract Atherosclerosis is a leading cause of cardiovascular diseases (CVDs), often resulting in major adverse events (MACEs), such as myocardial infarction and stroke due to the rupture or erosion vulnerable plaques. Ferroptosis, an iron‐dependent form cell death, has been implicated development atherosclerosis. Despite its involvement CVDs, specific role ferroptosis atherosclerotic plaque stability remains unclear. In this study, we confirmed presence unstable plaques demonstrated that...

The global phenomenon of cyanobacterial bloom pollution is spreading globally due to climate change and eutrophication. It well established that harmful cyanobacteria produce a wide range toxins including microcystin-LR (MC-LR), cyclic heptapeptide toxin known damage various organs. intestinal tract the main site MC-LR absorption one targets susceptible toxicity. Currently, studies on enterotoxic effects predominantly focused colorectum, with limited investigations addressing impact...

Thymosin β4 (Tβ4) is closely associated with the cytoskeleton, inflammation, wound healing, angiogenesis, apoptosis, and myocardial regeneration, but effects of Tβ4 treatment on chronic renal tubular interstitial fibrosis (CRTIF) are poorly known. This study aimed to examine apoptosis expression transforming growth factor (TGF-β), E-cadherin, α-smooth muscle actin (α-SMA) in CRTIF rat models.

Cardiovascular disease is the world’s leading cause of death, and there a substantial clinical need for transplantable blood vessels. Through tissue vascular engineering technology, large vessel grafts with significant effects have been synthesized. However, synthesizing valves, small vessels up to 6 mm in diameter, capillary networks 500 μm diameter remains challenging due lack precise manufacturing techniques. In particular, constructing microvascular network thick...

Introduction: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease, which mainly characterized by joint swelling, pressure pain and destruction. Some patients may suffer from variety of serious complications, require prompt diagnosis treatment. Otherwise, the patient condition deteriorate rapidly, leading to premature death. Objective: We reported case RA combined with hyperferritinemic syndrome capillary leak (CLS) that was successfully treated tocilizumab (TCZ), aim improving...

Objective Systemic sclerosis (SSc) is a chronic systemic disease characterized by immune dysregulation and fibrosis for which there no effective treatment. Animal models are crucial advancing SSc research. Tree shrews genetically, anatomically, immunologically closer to humans than rodents. Thus, the tree shrew model provides unique opportunity translational research in SSc. Methods In this study, was constructed subcutaneous injection of different doses bleomycin (BLM) 21 days. We assessed...

Objective Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by fibrosis. The challenge of early diagnosis, along with the lack effective treatments for fibrosis, contribute to poor therapeutic outcomes and high mortality SSc. Therefore, there an urgent need identify suitable biomarkers diagnosis Methods Three skin gene expression datasets SSc patients healthy controls were downloaded from Gene Expression Omnibus (GEO) database (GSE130955, GSE58095, GSE181549). GSE130955...

Aim. This study investigated the effect of tumor size and other factors on survival prognosis hepatocellular carcinoma (HCC). Methods. All HCC populations based National Cancer Institute’s SEER database to receive from 2010 2016 were employed in study. Results. enrolled a total 14,634 HCC. Among them, 1,686 patients had tumors ≤ 2 cm, 6,169 2–5 6,779 > 5 cm. The results using univariate analysis showed that all significant prognostic for overall specific survival. Patients with cm more...

NADPH oxidase 4 (NOX4), a member of the Nicotinamide Adenine Dinucleotide Phosphate (NADPH) family, its biological functions are closely associated with tumor progression. Gastric cancer (GC) is one most common malignancies in worldwide, poor prognosis for late-stage patients. However, relevance NOX4 GC remains unclear. We obtained pan-cancer data from The Cancer Genome Atlas (TCGA) database, and analyzed expression STAD. Further validation differential adjacent tissues were performed...

Microcystin-LR (MC-LR), a class of cyclic heptapeptide compounds synthesized by cyanobacterial species, presents significant risk to ecological systems and public health. Exposure MC-LR was found induce damage various organs. One the target organ affected is gastrointestinal tract (GIT). However, majority studies regarding GIT focused on colorectal toxicity, with little attention paid small intestinal toxic injuries, in particular jejunum. Thus, aim this study investigate effects attributed...

In recent years, the outbreak of cyanobacterial blooms has become increasingly frequent. Microcystin-LR (MC-LR), a metabolite cyanobacteria, poses significant threat to ecosystem and human health. Several studies have demonstrated that MC-LR might induce renal cell apoptosis, as consequence tissue damage. However, molecular mechanisms underlying MC-LR-initiated injury remain be determined. This investigation aimed determine role apoptosis in MC-LR-induced kidney damage its potential using...

Objective To explore the correlation and clinical application of turbidimetric inhibition immunoassay (TINIA) ion-exchange high-performance liquid chromatography (HPLC) for detecting glycosylated hemoglobin (HbAlC).Methods According to criteria on NCCLS,experiments precision,linearity,method comparison,and bias were conducted.The results analyzed by regression equation t test.Results The concentration HbAlc at a range 3.9％-15.2％ had good repeatability linearity TINIA or HPLC.Bias analysis...

Objective To study the clinical significance of glycosylated hemoglobin(HbA1c)in preventing,diagnosing,and monitoring gestational diabetes mellitus(GDM).Methods 200 women,21-30weeks pregnant and aged 19-40,were selected then were divided into a normal group GDM according to new standard IADPSG,100 for each group.FPG,OGTT,and HbA1c determined in both groups,and their results statistically analyzed compared.Results FPG,OGTT,and obviously higher than control group,with statistical...

Four-dimensional flow MRI (4D MRI) plays a significant role in cardiovascular imaging, which provides new insights into the pathophysiology of disease. In this study, 4D with echo-planar imaging was introduced to evaluate hemodynamic parameters patients abdominal aortic aneurysm, including velocity, and wall shear stress. We propose that EPI can find differences above between aneurysm normal aorta has potential be used for hemodynamics assessment AAA patients.

Abstract Background: Stricture in patients with Crohn’s disease (CD) carries a high risk of CD-related surgery the course disease. The aim this study was to assess rate occurrence and determine baseline factors predicting subsequent patient group. Methods: Patients registered stricturing CD were included. All follow-up data collected retrospectively. attended clinic for at week 14 their response infliximab (IFX). observational endpoint. Univariate multivariate Cox regression analyses used....

Abstract Objective: Identify risk factors associated with maternal and fetal outcomes in pregnant patients systemic lupus erythematosus (SLE). Methods: Retrospective analysis of the characteristics pregnancy 283 women SLE. Results: The mean age at delivery was 29.3±4.7 years, SLE duration 6.1±4.6 151 (53.3%) had adverse (APOs). APO group lower levels C3 C4, greater level anti dsDNA antibodies, higher albumin-to-creatinine ratio (ACR), frequent history nephritis (LN), use cyclosporine A...

Abstract Background To investigate whether patient-specific instrumentation (PSI) improves the femoral component positioning of implants during unicompartmental knee arthroplasty (UKA) using cadaver bone models. Methods Fifty adult cadaveric specimens collected from February 2016–2018, were randomized to receive medial UKA with a PSI guide (n = 25) or conventional (CI) 25). Standard anteroposterior and lateral view radiographs obtained postoperatively assess coronal sagittal prostheses,...

In patients, Type 2 Diabetes Mellitus (T2DM) and Diabetic Nephropathy (DN) have unknown initiation time points, likely well before their respective clinically‐defined features of elevated fasting glucose/HbA1c reduced eGFR/microalbuminuria respectively, preceding and/or causal mechanisms or events (genetic otherwise). part, this is due to animal models that do not fully reflect the human condition, show same progressive processes overt onset symptoms, similar associations contributing...

Abstract Purpose Coronavirus disease (COVID-19) pandemic is now a global health concern. However, there no detailed analysis of the factors related to patients’ improvement. Patients and methods We compared clinical characteristics, laboratory findings, CT images, treatment COVID-19 patients from two different cities in China. One hundred sixty-nine were recruited January 27 March 17, 2020 at five hospitals Hubei Guangxi. They divided into four groups according age presence comorbidities....