A5100735835- Dialysis and Renal Disease Management
- Acute Kidney Injury Research
- Chronic Kidney Disease and Diabetes
- Connective Tissue Growth Factor Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Sepsis Diagnosis and Treatment
- Domain Adaptation and Few-Shot Learning
- Traditional Chinese Medicine Analysis
- Central Venous Catheters and Hemodialysis
- 3D Printing in Biomedical Research
- Tissue Engineering and Regenerative Medicine
- Inflammasome and immune disorders
- Wnt/β-catenin signaling in development and cancer
- Endoplasmic Reticulum Stress and Disease
- Chromatography in Natural Products
- Lipid metabolism and disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Kidney Stones and Urolithiasis Treatments
- Systemic Sclerosis and Related Diseases
- Sentiment Analysis and Opinion Mining
- Phytochemical and Pharmacological Studies
- Blood properties and coagulation
- Cellular Mechanics and Interactions
- Phytochemistry and Bioactive Compounds
- Sirtuins and Resveratrol in Medicine
Guizhou Provincial People's Hospital
2012-2022
First Affiliated Hospital of Wannan Medical College
2020
Southern Medical University
2015
Nanfang Hospital
2015
Large language models (LLMs) demonstrate impressive performance on downstream tasks through in-context learning(ICL). However, there is a significant gap between their in Named Entity Recognition (NER) and fine-tuning methods. We believe this discrepancy due to inconsistencies labeling definitions NER. In addition, recent research indicates that LLMs do not learn the specific input-label mappings from demonstrations. Therefore, we argue using examples implicitly capture mapping inputs labels...
Renal fibrosis is the final common pathway of all progressive renal disease. Excessive and chronic activation Wnt/β-catenin signaling results in kidney disease (CKD) progression. To mimic CKD, present study used 5/6-nephrectomized rats, alterations histology, expression β‑catenin cell apoptosis were assessed. In addition, mesangial cells cultured vitro transfected with siRNA to evaluate effect blocking Wnt/β‑catenin on markers fibrosis. The demonstrated that CKD rat tissues exhibited...
Diabetic nephropathy (DN) is the second most common complication of diabetes mellitus after cardiovascular complications. Endoplasmic reticulum (ER) stress known to be associated with DN. Resveratrol (RSV) exhibits anti‑oxidative, anti‑inflammatory and cytoprotective effects. Therefore, aims present study were investigate role RSV in inhibition high concentration glucose (HG)‑induced apoptosis renal tubular cells, as well examine protective effects against diabetes‑mediated damage via ER was...
Thymosin β4 (Tβ4) is closely associated with the cytoskeleton, inflammation, wound healing, angiogenesis, apoptosis, and myocardial regeneration, but effects of Tβ4 treatment on chronic renal tubular interstitial fibrosis (CRTIF) are poorly known. This study aimed to examine apoptosis expression transforming growth factor (TGF-β), E-cadherin, α-smooth muscle actin (α-SMA) in CRTIF rat models.
<b><i>Background/Aim:</i></b> The relationship between body mass index (BMI) and intradialytic hypotension (IDH) has been inconsistently reported, but no further research investigated the correlation composition IDH so far. This study aimed to determine whether lean tissue (LTI), fat (FTI), or both derived from monitoring (BCM) is associated with defined as a nadir systolic blood pressure of &#x3c;90 mm Hg ≥3 episodes per 10 hemodialysis (HD) treatments in...
Obesity is a well-established risk factor for atherosclerosis. However, it unknown which measure of adiposity best relates to atherosclerosis in relatively lean maintenance hemodialysis (MHD) patients. We aimed explore and compare the associations between different indices reflecting general, abdominal, visceral arteriosclerosis with atherogenic index plasma(AIP) MHD conducted multicenter, cross-sectional study Guizhou Province, Southwest China. General/abdominal like body mass (BMI), waist...
Text is ubiquitous in our visual world, conveying crucial information, such as documents, websites, and everyday photographs. In this work, we propose UReader, a first exploration of universal OCR-free visually-situated language understanding based on the Multimodal Large Language Model (MLLM). By leveraging shallow text recognition ability MLLM, only finetuned 1.2% parameters training cost much lower than previous work following domain-specific pretraining finetuning paradigms. Concretely,...
Objective: To analyze the influencing factors of protein energy wasting (PEW) in maintenance hemodialysis (MHD) patients. Methods: A multicenter cross-sectional study was conducted eleven centers Guizhou province between June and August 2018. Clinical data, physical parameters, body composition data laboratory values MHD patients were collected. Analysis variance used to assess impact indicators on prevalence PEW. Factor analysis carried out after further classifing into several common...
Objective: Immune inflammatory cells and cytokines play an important role in the occurrence development of diabetic nephropathy (DN). Acteoside has been reported to regulate inflammation immune response. The study aims investigate effects acteoside on expressions MCP-1 TGF-β 1 mice. Methods: C57BL/6J mice model group were given a single intraperitoneal injection STZ (150 mg/kg). Model divided randomly into two groups: 5 without treatment, treated with acteoside. After continuous...
Acute renal ischemia may cause acute dysfunction due to lack of blood supply; the manifestations are tubular cell apoptosis, infiltration macrophages, and microvascular destruction. Many studies have shown that erythropoietin (EPO) vitamin D3 (VD3) can be used prevent or treat ischemia-reperfusion (I/R) injury, VD3 interact with EPO. In present study, effects combination EPO in I/R kidney injury were studied. Rats divided into 5 groups: sham-operated (SHAM), AKI without treatment...
Objective: Acteoside (ACT) has been reported to regulate the inflammation and immune response. The study aims explore effect of ACT on renal fibrosis in unilateral ureteral obstruction (UUO) rats. Methods: Eighteen Sprague-Dawley rats were randomly divided into 3 groups: sham group, opened abdominal cavity sutured abdominal; UUO performed surgery; + (40 mg/kg) was given by gavage every day after surgery. After 2 weeks rat model construction, urine blood samples collected for biochemical...
本研究旨在比较不同内脏肥胖指标及人体测量学指标对非肥胖维持性血液透析（MHD）患者代谢综合征（MS）的诊断效能。纳入多中心1302例非肥胖MHD患者，收集身高、腰围（WC）、血生化等指标。计算中国人内脏脂肪指数（CVAI）、内脏脂肪指数（VAI）、脂肪堆积产物指数（LAP）、身体圆度指数（BRI）及体重指数（BMI）、腰高比（WHtR），采用受试者工作特征曲线（ROC）评估非肥胖MHD患者发生MS的最佳诊断指标。结果发现，各指标的ROC曲线下面积（AUC）大小在男性中排序为：LAP（AUC=0.84）>VAI（AUC=0.82）>CVAI（AUC=0.77）>WC（AUC=0.76）>WHtR（AUC=0.75）/BRI（AUC=0.75）>BMI（AUC=0.69）；在女性中排序为：LAP（AUC=0.85）>VAI（AUC=0.84）>WC（AUC=0.77）>WHtR（AUC=0.75）/BRI（AUC=0.75）>CVAI（AUC=0.73）/BMI（AUC=0.73）。作者认为，LAP及VAI诊断非肥胖MHD患者MS的效能强于CVAI、BRI、WC、WHtR及BMI；L...