A5101115209- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Atherosclerosis and Cardiovascular Diseases
- Circular RNAs in diseases
- Lipoproteins and Cardiovascular Health
- Ferroptosis and cancer prognosis
- Cancer, Lipids, and Metabolism
- Cholesterol and Lipid Metabolism
- T-cell and B-cell Immunology
- Medical Imaging and Pathology Studies
- Protease and Inhibitor Mechanisms
- Cancer Mechanisms and Therapy
- Trace Elements in Health
- Medical Imaging Techniques and Applications
- Alzheimer's disease research and treatments
- Peroxisome Proliferator-Activated Receptors
- Nuclear Receptors and Signaling
- Kruppel-like factors research
- Drug Transport and Resistance Mechanisms
- Radiopharmaceutical Chemistry and Applications
- Hippo pathway signaling and YAP/TAZ
- Computational Drug Discovery Methods
University of South China
2015-2024
Abstract Atherosclerosis is a leading cause of cardiovascular diseases (CVDs), often resulting in major adverse events (MACEs), such as myocardial infarction and stroke due to the rupture or erosion vulnerable plaques. Ferroptosis, an iron‐dependent form cell death, has been implicated development atherosclerosis. Despite its involvement CVDs, specific role ferroptosis atherosclerotic plaque stability remains unclear. In this study, we confirmed presence unstable plaques demonstrated that...
Recent studies have shown that a class of small, functional RNAs, named microRNAs, may regulate multidrug resistance-associated protein 1 (ABCC1). Since ABCC1 is an important efflux transporter responsible for cellular drug disposition, the discovery microRNAs (miRNA) brings idea there be some other unknown resistance (MDR) mechanisms exist. Using computational programs, we predicted 3′untranslated region (3′UTR) contains potential miRNA binding site miR-133a and also two miR-326. These...
Atherosclerosis (AS) is a major contributor to morbidity and mortality worldwide. However, the molecular mechanisms mediator molecules involved remain largely unknown. Copper, which plays an essential role in cardiovascular disease, has been suggested as potential risk factor. Copper homeostasis closely related occurrence development of AS. Recently, new cell death pathway called cuproptosis discovered, driven by intracellular copper excess. no previous studies have reported relationship...
Hydrogen sulfide (H2S) is an endogenous gaseous signaling molecule that plays important roles in the cardiovascular system. In our previous studies, we demonstrated H2S regulates lipid metabolism. present study, aimed to explore mechanisms through which metabolism HepG2 cells vitro. Treatment of with inhibited expression proprotein convertase subtilisin/kexin type 9 (PCSK9) and increased level low‑density lipoprotein receptor (LDLR) a time‑ dose‑dependent manner. The knockdown PCSK9 by siRNA...
Chemotherapy is one of the most common treatments used for hepatocellular carcinoma (HCC), which effectively improves outcome and reduces tumor recurrence. However, drug resistance mechanisms involved in chemotherapy, predominant challenge HCC treatment, remain to be fully elucidated. Therefore, there an urgent requirement identification novel therapeutic strategies or drugs. MicroRNAs (miRs) have become area interest, present study, effects miR‑133a miR‑326 on HepG2 cells, their function...
Abstract: The proprotein convertase subtilisin/kexin type 9 (PCSK9) belongs to a member of the (PC) family, which is mainly secreted by liver and plays central role in lipid metabolism. Furthermore, PCSK9 multifunctional promoting inflammatory response, inducing cell apoptosis pyroptosis affecting tumor homeostasis. brain organ with richest content. Incidentally, increased many diseases, including injury Alzheimer’s disease (AD). Consequently, relationship between diseases has attracted...
To investigate effects of miR-503 on cisplatin sensitivity in BEL-7402 cells by targeting bcl-2. Methods: MiR-503 and bcl-2 mRNA expression levels hepatocellular carcinoma were measured real-time quantitative (qRT)-PCR; Bcl-protein level was detected Western blot; mimics transiently transfected to the liposome transfection; potential target genes predicted Bioinformatics software; targets validated dual luciferase activity; cell viability MTT assay. Results: down-regulated Bcl-2 protein...