A5038292641- Viral-associated cancers and disorders
- Lymphoma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- T-cell and Retrovirus Studies
- MicroRNA in disease regulation
- RNA modifications and cancer
- Immune Cell Function and Interaction
- Cancer-related gene regulation
- Wnt/β-catenin signaling in development and cancer
- Cytomegalovirus and herpesvirus research
- Hepatitis C virus research
- Circular RNAs in diseases
- Animal Disease Management and Epidemiology
- Eosinophilic Disorders and Syndromes
- Helicobacter pylori-related gastroenterology studies
- Cancer Mechanisms and Therapy
- Herpesvirus Infections and Treatments
- Hepatitis B Virus Studies
- TGF-β signaling in diseases
- Invertebrate Immune Response Mechanisms
- Immune cells in cancer
- Ubiquitin and proteasome pathways
- Genomics, phytochemicals, and oxidative stress
- Insect Utilization and Effects
- Cell death mechanisms and regulation
University of South China
2013-2024
Wenzhou Medical University
2023
Colorado State University
2019
Hunan Cancer Hospital
2019
First Affiliated Hospital of University of South China
2005
Nanhua University
2005
Stockholm University
1987-1991
Academia Sinica
1984
Cecropins A, B, and D are antibacterial peptides of 35-37 amino acids that synthesized in pupae the Cecropia moth (Hyalophora cecropia) as a response to bacterial infection. cDNA cloning has shown cecropins made preproproteins processed four steps mature peptides. We have now cloned genes for preprocecropins A D, data together with earlier work on B gene it possible deduce arrangement cecropin locus. The three organized large cluster spanning 20 kilobases DNA each there is one copy/haploid...
Levels of the Wnt pathway components are abnormally altered in gastric cancer cells, leading to malignant cell proliferation, invasion and metastasis, poor prognosis chemoresistance. Therefore, it is important understand mechanism signaling cancer. We systematically reviewed molecular mechanisms development; summarize progression challenges research on agents pathway.
Epstain-Barr virus (EBV) can transform human B lymphocytes making them immortalized and inducing tumorigenic ability in vitro, but the molecular mechanisms remain unclear. The aim of present study is to detect analyze differentially expressed genes two types host cells, normal coupled EBV-transformed lymphoblasts vitro using gene chips, screen key regulatory lymphocyte transformation induced by EB virus.Fresh peripheral blood samples from seven healthy donors were collected. EBV was used...
MicroRNAs (miRNAs) are internal, non-coding, and ∼22 nt small RNAs that display cell- tissue-specific expression. They play important regulatory roles in cell proliferation chemo-sensitivity. This study focused on tumor-suppressive miR-33b-5p expression as well its role gastric cancer. MiR-33b-5p was found low cancer lines. Functionally, western blots the luciferase reporter assay were used to confirm HMGA2 potential target of miR-33b-5p. Next, we CCK-8 kits analyze effect combined...
Aging is regarded as a dominant risk factor for cancer. Additionally, inflammation and asthenic immune surveillance with aging may facilitate tumor formation development. However, few studies have comprehensively analyzed the relationship between aging-related genes (AGs) prognosis, immunity of head neck squamous cell carcinoma (HNSCC). Here, we initially screened 41 differentially expressed AGs from The Cancer Genome Atlas (TCGA) database. In training set, prognosis model seven (APP,...
Primary effusion lymphoma (PEL) is a common cancer in AIDS patients closely associated with Kaposi's sarcoma-associated herpesvirus (KSHV). Previously, we showed that KSHV latency nuclear antigen (LANA) stabilizes intracellular activated Notch1 (ICN) involved maintenance of the malignant phenotype infected PEL cells vitro. The γ-secretase inhibitor (GSI) which specifically blocks production ICN slows down proliferation cell lines BCBL1, BC3 as well JSC1 In this study, extended these studies...
To analyze the association of several types malignant lymphomas in different anatomical sites with Epstein-Barr virus (EBV) infection status, 127 cases formalin-fixed paraffin-embedded samples were investigated situ hybridization detecting EBV-encoded small RNA (EBER) tumor cells. Forty-six out 108 non-Hodgkin lymphoma (NHL) positive for EBER (42.6%). The EBER-positivity rate NHL nasal cavity and nasopharynx (35/60 cases, 58.3%) was higher than that stomach (9/30 30%) superficial lymph nodes...
Infection with Epstein-Barr virus (EBV) induces activation and proliferation of B lymphocytes. Detection latent membrane protein (LMP)-1 is used to identify the proliferative ability cells. However, changes in expression levels three LMPs during EBV-induced lymphocyte transformation, have not yet been reported. In present study, LMP-1, LMP-2A LMP-2B were compared between EBV-transformed lymphocytes paired normal Seven lymphoblast cell lines established by EBV infection human vitro. The LMP...
We previously constructed human peripheral blood lymphocyte (hu‐PBL)/severe combined immunodeficiency mouse (SCID) chimeras and induced B‐cell lymphomas associated with Epstein‐Barr virus (EBV) in SCID mice. However, a number of mice died graft‐versus‐host disease (GVHD) during the early experimental course. The aim this study was to test efficacy cyclosporine A (CSA) for prevention GVHD define how CSA inhibits occurrence production soluble interleukin (IL) 2 receptor (sIL‐2R) hu‐PBL/SCID No...
Aims and background The mechanisms of Epstein-Barr virus (EBV)-associated tumor development are incompletely understood. aim this study was to investigate the gene expression EBV-associated lymphomas in hu-PBL/SCID mice. Methods Human peripheral blood lymphocytes (hu-PBL) from EBV-seropositive donors were transplanted into severe combined immunodeficiency (SCID) In situ hybridization used detect EBV-encoded small RNA-1 (EBER1) tissues. Mutation TP53 exons 5–8 EBV-induced analyzed by...
Abstract Background Epstein-Barr virus (EBV) has a close association with various types of human lymphomas. Animal models are essential to elucidate the pathogenesis EBV-associated The aim present study is evaluate between IgG concentration and lymphoma development in huPBL/SCID mice. Methods Human peripheral blood lymphocytes (hu-PBL) from EBV-seropositive donors were inoculated intraperitoneally into SCID mouse. Immunohistochemical staining was used examine differentiated antigens tumor...
Epstein-Barr virus (EBV) is a human oncogenic herpesvirus associated with lymphoma and nasopharyngeal carcinoma. Because the susceptible hosts of EB are limited to cotton-top tamarins (Saguinus oedipus), there have been no appropriate animal models until model induced by EBV in peripheral blood lymphocyte (hu-PBL)/SCID chimeric mice was reported. However, it still controversial whether EBV-associated hu-PBL/SCID monoclonal tumor. In this study, we transplanted normal lymphocytes (hu-PBL)...
Although the Epstein-Barr virus (EBV) is a well-known human oncogenic virus, its molecular mechanisms involved in transformation of healthy cells remain poorly understood. In this study, lymphocytes were isolated from peripheral blood adults, and transformed vitro by EBV. Agilent whole genome microarrays used to detect differential gene expression profiles EBV-transformed lymphoblasts (PBLs). By constructing functional network EBV-induced lymphocyte transformation, we screened out candidate...