A5100635234- Immune Response and Inflammation
- Lipid Membrane Structure and Behavior
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Glycosylation and Glycoproteins Research
- Cell Adhesion Molecules Research
- Mine drainage and remediation techniques
- Radiopharmaceutical Chemistry and Applications
- Nanoparticle-Based Drug Delivery
- Cellular Mechanics and Interactions
- Digestive system and related health
- Monoclonal and Polyclonal Antibodies Research
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Prostate Cancer Treatment and Research
- Congenital gastrointestinal and neural anomalies
- Metal Extraction and Bioleaching
- Nuclear Receptors and Signaling
- Anesthesia and Neurotoxicity Research
- Galectins and Cancer Biology
- Gastrointestinal motility and disorders
- Neurogenesis and neuroplasticity mechanisms
- Coal and Its By-products
- Inflammatory mediators and NSAID effects
- Nerve injury and regeneration
University of Chinese Academy of Sciences
2018-2024
Beijing Hospital
2024
Institute of Biophysics
2024
Center for Excellence in Molecular Cell Science
2012-2023
Nanjing University of Chinese Medicine
2020
Chinese Academy of Sciences
1995-2016
Shanghai Institutes for Biological Sciences
2012-2016
Ningxia Medical University
2012
Chinese Academy of Agricultural Sciences
2007
Biotechnology Research Institute
2007
FcγRIIB functions to suppress the activation of immune cells. A single-nucleotide polymorphism in transmembrane (TM) domain FcγRIIB, FcγRIIB-T232, is associated with lupus. In this study, we investigated pathogenic mechanism FcγRIIB-T232 at both functional and structural levels. Our results showed that exhibited significantly reduced lateral mobility compared FcγRIIB-I232 was less enriched into microclusters complexes (ICs) after stimulation. However, if sufficient responding time given for...
Leptospirillum ferriphilum strain UBK03 isolated from a mine in Jiangxi, China, is resistant to Ni(2+) (30 40 mM). A four-gene nickel resistance cluster was identified and, when transformed into Escherichia coli, enabled growth 6 mM nickel. Mutation experiments revealed that the genes ncrA, ncrB, and ncrC could confer whereas gene ncrY have negative effect on resistance.
Protein transmembrane domains (TMDs) are generally hydrophobic, but our bioinformatics analysis shows that many TMDs contain basic residues at terminal regions. Physiological functions of these membrane-snorkeling largely unclear. Here, we show a Lys residue in integrin αLβ2 (also known as lymphocyte function-associated antigen 1 [LFA-1]) regulates heterodimer formation and adhesion through ionic interplay with acidic phospholipids calcium ions (Ca2+) T cells. The amino group the conserved...
The integrin receptor protein talin plays vital roles in intracellular chemical and mechanical activities, it is implicated the high invasion poor prognosis of non-small cell lung cancer (NSCLC). To better understand mechanism underlying function NSCLC metastasis, a few newly designed tension probe based on Förster resonance energy transfer was used for real-time observation changes A549 cells. High aggressiveness found to be accompanied with inward outward glial fibrillary acidic (GFAP)...
Specific molecular probes are essential for the early diagnosis of prostate cancer. In addition, peptides have been shown to numerous uses as diagnostic and therapeutic probes. The K237 peptide binds vascular endothelial growth factor receptor with high affinity specificity, was predicted potential use a probe in tumor angiogenesis. overall aim present study assess 131I‑K237 radiolabeled 131I using an Iodogen method. radiolabeling efficiency radiochemical purity were found be 73.7±3.2...