A5100639492- Meningioma and schwannoma management
- Neurofibromatosis and Schwannoma Cases
- Retinal Diseases and Treatments
- Vascular Malformations Diagnosis and Treatment
- Retinal Imaging and Analysis
- Liver Disease Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Glaucoma and retinal disorders
- Obstructive Sleep Apnea Research
- Gout, Hyperuricemia, Uric Acid
- Adrenal and Paraganglionic Tumors
- Retinal and Macular Surgery
- Pituitary Gland Disorders and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Neuroscience of respiration and sleep
- Adipose Tissue and Metabolism
- Sleep and Wakefulness Research
- Inflammatory Biomarkers in Disease Prognosis
- Lung Cancer Research Studies
- HER2/EGFR in Cancer Research
- Neuroblastoma Research and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Diet and metabolism studies
- Brain Metastases and Treatment
- Growth Hormone and Insulin-like Growth Factors
Beijing Tian Tan Hospital
2018-2024
First Affiliated Hospital of Guangzhou Medical University
2021-2024
State Key Laboratory of Respiratory Disease
2021-2024
Guangzhou Medical University
2021-2024
Capital Medical University
2019-2024
Zhejiang University
2024
Tianjin Medical University General Hospital
2022-2024
Heilongjiang University
2024
Memorial
2023
Ningbo Medical Center Lihuili Hospital
2016-2023
Polycystic ovary syndrome is one of the most common endocrine disorders among women childbearing age. The relationship between polycystic and chronic kidney disease remains unclear controversial. In this study, we investigated causal role in development using two-sample Mendelian randomization method.
Obstructive sleep apnea (OSA) is a common chronic disease with various comorbidities. The cardiometabolic index (CMI) reflects visceral fat tissue distribution and function, assessing the risk of obesity-related conditions such as metabolic syndrome (MetS) stroke, which are strongly connected to OSA. relationship between CMI OSA combined MetS (OMS) remains unclear. This study aims evaluate screening value for OMS, compared lipid accumulation product (LAP). A total 280 participants who...
Abstract Background Observational studies have shown that nonalcoholic fatty liver disease (NAFLD) is highly correlated with serum uric acid (SUA). However, these an inherent risk of bias due to reverse causality. Here, we perform a Mendelian randomization (MR) study investigate causality between SUA and NAFLD. Methods We performed 2-sample bidirectional MR analysis using summary-level data from genome-wide association (with up 110 347 individuals) NAFLD (1483 cases 17781 controls) in...
This study aims to provide evidence for an association between the consumption of prebiotics and probiotics hyperuricemia in U.S. adults. A total 7,176 adults who participated National Health Nutrition Examination Survey (NHANES) during 2011-2018 were included study. First, baseline characteristics data described weighted data, using presence or absence as classification criterion. Second, binary logistic regression analyses performed establish crude models adjusted relevant covariates, odds...
Abstract Normal human mammary epithelial cells (HMECs) proliferate in a serum‐free defined growth medium the absence of epidermal factor (Li and Shipley, 1991). Amphiregulin (AR) is heparin‐regulated, EGF‐like factor. Our observation that one strain HMECs produce AR mRNA (Cook et al., 1991a) stimulated us to determine whether expression was common phenomenon could act as an autocrin support EGF‐independent these cells. In this study, we detected high levels four separate HMEC strains while...
The hemoglobin glycation index (HGI) represent the disparity between actual glycated measurements and predicted HbA1c. It serves as a proxy for degree of non-enzymatic hemoglobin, which has been found to be positively correlated with diabetic comorbidities. In this study, we investigated relationship HGI non-alcoholic fatty liver disease (NAFLD), along other relevant biological markers in patients diabetes.This cross-sectional study consisted 3,191 adults diagnosed type 2 diabetes mellitus....
Adult intracranial ependymomas (EPNs) are extremely rare brain tumors. Currently, clinical and molecular factors that could inform individualized treatment strategies still lacking for EPNs in this age group. The aim of study was to investigate potential prognostic indicators rational therapeutic management a large cohort adult EPNs. patients who underwent resection World Health Organization (WHO) grade II or III were included. demographic features, clinicopathologic manifestations,...
To perform a quantitative analysis of retinal microvasculature in patients with early-stage diabetic retinopathy (DR) using wide-field swept-source optical coherence tomography angiography (SS-OCTA). METHODS: One hundred nineteen eyes 119 patents (67 no DR and 52 mild-moderate nonproliferative (NPDR)) were enrolled this observational cross-sectional cohort study, an age-matched group consisting 39 non-diabetic subjects set as the control. Each participant underwent full ophthalmic...
Background Studies on the prognostic factors for patients with brain oligo-metastasis treated fractionated stereotactic radiotherapy (FSRT) usually focus size of metastatic tumor and radiation dose. Some inflammatory indicators have predictive value in non-small cell lung cancer (NSCLC) metastasis receiving radiotherapy. However, NSCLC FSRT, their effect dose is unknown. Methods A total 95 advanced who had undergone FSRT treatment at Ningbo Medical Center Lihuili Hospital between January...
// Ling-Cui Ding 1 , Qian-Qian Gong Shi-Wei Li Xiao-Long Fu Ye-Cheng Jin Jian Zhang Jian-Gang Gao and Xiao-Yang Sun Institute of Developmental Biology, School Life Science, Shandong University, Jinan, China Correspondence to: Sun, email: sunxy70@sdu.edu.cn Keywords: Rcan2, 17β-estradiol, ovariectomy, body weight regulation, obesity Received: January 05, 2017 Accepted: May Published: 29, ABSTRACT Rcan2 increases food intake plays an important role in the development age- diet- induced male...
Hypoparathyroidism, sensorineural deafness, and renal dysplasia (HDR) syndrome (Barakat syndrome) is a rare autosomal dominant disorder caused by mutations in the gene encoding GATA3 on chromosome 10p14. Informed consent was obtained from 38-year-old female patient. 5 mL of venous blood collected sent for whole-exome sequencing. constructs both wild-type mutant were transfected into HEK-293 T cells. Three-dimensional modeling, luciferase-reporter test, western blotting cellular...
Purpose: People with hyperuricemia (HUA) are often related to metabolic disorders such as diabetes, syndrome (MetS), and obesity.However, the correlation between excretion of uric acid these diseases is unclear.Our study aimed explore relationship type 2 diabetes (T2D).Methods: A total 228 HUA patients from Tianjin Medical University General Hospital 2022 2023 were included in this study.We collected demographic, biochemical, anthropometric data on each subject.Urine (UUAE) was calculated...
Intracerebral haemorrhage (ICH) is a devastating disease that leads to severe neurological deficits. Microglia are the first line of defence in brain and play crucial role recovery after ICH, whose activities primarily driven by glucose metabolism. However, little known regarding status metabolism microglia its interactions with inflammatory responses ICH.
There are few published data concerning pituitary adenomas (PAs) derived from multiple lineages. In this study the authors aimed to determine clinicopathological characteristics and prognostic profiles of PAs with cell lineage combinations (PAwMCs).The reviewed on 723 patients who had undergone surgery between 2018 2021 identified 93 cases (12.9%) PAwMC. They collected detailed these cases, including clinical information, pathological features, prognosis. From among 589 only one (PAwOCs),...
Abstract Medulloblastoma (MB) is the most common malignant pediatric brain tumor arising in cerebellum or 4 th ventricle. Cerebellopontine angle (CPA) MBs are extremely rare tumors, with few cases previously described. In this study, we sought to describe clinical characteristics, molecular features and outcomes of CPA MB. We retrospectively reviewed a total 968 patients who had histopathological diagnosis MB at Beijing Neurosurgical Institute between 2002 2016. The demographic...
Treatment of schwannomas in patients with neurofibromatosis type 2 (NF2) is extremely unsatisfactory, and innovative therapeutic approaches are urgently needed. However, the lack clinically relevant NF2-associated schwannoma models has severely hampered drug discovery this rare disease. Here we report first establishment characterization patient-derived xenograft (PDX) cell line schwannoma, which recapitulates morphological histopathological features patient tumors, retain NF2 mutations,...