A5079975137- Liver Disease Diagnosis and Treatment
- Pancreatic function and diabetes
- Gout, Hyperuricemia, Uric Acid
- Endoplasmic Reticulum Stress and Disease
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pancreatitis Pathology and Treatment
- Alcohol Consumption and Health Effects
- Diabetes Management and Research
- Diabetes and associated disorders
- Diabetes Management and Education
- Electrolyte and hormonal disorders
- Ion Transport and Channel Regulation
- COVID-19 Clinical Research Studies
- Bariatric Surgery and Outcomes
- Lipid metabolism and disorders
- Pharmacology and Obesity Treatment
- Hormonal Regulation and Hypertension
- Neuroendocrine Tumor Research Advances
- Metabolism, Diabetes, and Cancer
- Diet and metabolism studies
- Nosocomial Infections in ICU
- Gut microbiota and health
- Peroxisome Proliferator-Activated Receptors
- Neurological Disease Mechanisms and Treatments
- Liver Disease and Transplantation
Tianjin Medical University General Hospital
2015-2025
Guiyang Medical University
2025
Affiliated Hospital of Guizhou Medical University
2025
Weifang People's Hospital
2018
University of Michigan
2015
Tianjin Medical University
2009-2014
Abstract Background Observational studies have shown that nonalcoholic fatty liver disease (NAFLD) is highly correlated with serum uric acid (SUA). However, these an inherent risk of bias due to reverse causality. Here, we perform a Mendelian randomization (MR) study investigate causality between SUA and NAFLD. Methods We performed 2-sample bidirectional MR analysis using summary-level data from genome-wide association (with up 110 347 individuals) NAFLD (1483 cases 17781 controls) in...
Increasing evidence indicates that many small secretory preproteins can undergo post-translational translocation across the membrane of endoplasmic reticulum. Although cellular machinery involved in has begun to be elucidated, intrinsic signals contained within these contribute their efficient remain unknown. Here, we analyzed eukaryotic proteome and discovered tend have a higher probability harbor positive charge n-region signal peptide (SP). Eliminating blocked newly synthesized...
The 2023 American Heart Association/American Stroke Association guideline and Wessels et al's 2024 randomized controlled trial highlight the potential benefits of intracranial nicardipine for aneurysmal subarachnoid hemorrhage (aSAH). This study aims to systematically identify publication trends research hotspots in this field through bibliometric analysis. Relevant publications were sourced from Web Science Core Collection (WoSCC). Bibliometric visualization analyses conducted using online...
This study aims to provide evidence for an association between the consumption of prebiotics and probiotics hyperuricemia in U.S. adults. A total 7,176 adults who participated National Health Nutrition Examination Survey (NHANES) during 2011-2018 were included study. First, baseline characteristics data described weighted data, using presence or absence as classification criterion. Second, binary logistic regression analyses performed establish crude models adjusted relevant covariates, odds...
Background: The pathogenesis of diabetes and diabetic kidney disease (DKD) is closely related to the imbalance gut microbiota. We aimed explore whether exogenous Akkermansia muciniphila (A. muciniphila) supplementation affected progression DKD. Methods: feces from normal subjects, patients without diseases, with DKD were collected, changes in microbial communities analyzed. A rodent db/db model was also constructed investigate abundance A. would be altered response renal function decline....
Aims: Diabetes mellitus (DM) has reached epidemic proportions among adults worldwide, with China having the world's largest population of individuals disease. Although consequences low rates awareness, treatment, and control DM are understood, sex-related differences in these remain unknown. We assessed prevalence, a low-income, rural China. Materials Methods: Individuals ≥45 years old without cardiovascular disease were recruited into this study. The both men women after accounting for age,...
Objectives: China has already entered the aging society, and its population is largest worldwide. Accordingly, several aging-related conditions including hyperuricemia are becoming a public health concern owing to their increasing prevalence in rural areas. However, sex-specific differences risk factors for among middle-aged elderly North unclear. Thus, this study aimed evaluate of low-income adults China. Methods: This population-based cross-sectional recruited participants aged ≥50 years...
The hemoglobin glycation index (HGI) represent the disparity between actual glycated measurements and predicted HbA1c. It serves as a proxy for degree of non-enzymatic hemoglobin, which has been found to be positively correlated with diabetic comorbidities. In this study, we investigated relationship HGI non-alcoholic fatty liver disease (NAFLD), along other relevant biological markers in patients diabetes.This cross-sectional study consisted 3,191 adults diagnosed type 2 diabetes mellitus....
Upon translocation across the endoplasmic reticulum (ER) membrane, secretory proteins are proteolytically processed to remove their signal peptide by peptidase (SPase). This process is critical for subsequent folding, intracellular trafficking, and maturation of proteins. Prokaryotic SPase has been shown be a promising antibiotic target. In contrast, date, no eukaryotic inhibitors have reported. Here we report that introducing proline immediately following natural cleavage site not only...
Aims This cross-sectional study compared the value of molecular imaging (Exendin-4 positron emission tomography/computed tomography [PET/CT], 68 Ga-DOTATATE PET/CT, 18 F- fluorodeoxyglucose [FDG] PET/CT) in insulinoma localization by stratified tumor size and grading, explored correlation related maximum standardized uptake (SUVmax) with Ki-67, diameter, glucose metabolism. Methods In 28 patients, sensitivity three types PET/CT for localizing was calculated according to grade. We SUVmax...
The translocon-associated protein-δ (TRAPδ) plays a role in insulin biosynthesis within pancreatic β-cells. However, its pathophysiological significance maintaining islet β-cell function and glucose homeostasis remains unclear. In this study, we generated mouse model featuring β-cell–specific deletion of TRAPδ (TRAPδ βKO). Our findings revealed that βKO resulted decreased circulating levels mice fed either normal chow diet or high-fat diet. Multiple independent experiments established...
To assess the association between vitamin D status and all-cause mortality among type 2 diabetes patients.We prospectively followed 1,291 participants with aged 20-80 years during 2013-2018. Cox proportional hazard regression models were used to estimate different risk hospitalized patients diabetes.During a median follow-up of 4.15 (5,365 person-years in total), 61 cases death identified. Multivariable-adjusted ratios (HRs) for across quartiles baseline circulating 25-hydroxy (25-OH D) 2.70...
Sex hormones play an important role in the pathogenesis of cardiovascular disease (CVD). This cross-sectional study aimed to explore associations dehydroepiandrosterone (DHEA) and sulfate (DHEAS) with coronary heart (CHD) stroke middle-aged elderly patients type 2 diabetes mellitus (T2DM). A total 995 T2DM were included analysis. Serum levels DHEA DHEAS quantified using liquid chromatography-tandem mass spectrometry. Binary logistic regression analyses performed assess CHD stroke. Receiver...
Insulin resistance in classic insulin-responsive tissues is a hallmark of type 2 diabetes (T2D). However, the pathologic significance β-cell insulin and underlying mechanisms contributing to defective signaling β cells remain largely unknown. Emerging evidence indicates that proinsulin misfolding not only molecular basis mutant INS-gene-induced youth (MIDY) but also an important contributor development progression T2D. failure caused by misfolded still incompletely understood. Herein, using...
Objective This study aimed to evaluate the effect of adiposity and fat distribution on odds elevated cardiovascular risk factors among adults with type 2 diabetes mellitus. Methods The present cross‐sectional included 2,427 Body was assessed by dual‐energy x‐ray absorptiometry. Multivariate‐adjusted logistic regression used estimate effects parameters hemoglobin A 1c (HbA , ≥7.0%), hypertension (blood pressure ≥140/90 mmHg), low‐density lipoprotein (LDL) cholesterol (≥2.6 mmol/L). Results...
Hypoparathyroidism, sensorineural deafness, and renal dysplasia (HDR) syndrome (Barakat syndrome) is a rare autosomal dominant disorder caused by mutations in the gene encoding GATA3 on chromosome 10p14. Informed consent was obtained from 38-year-old female patient. 5 mL of venous blood collected sent for whole-exome sequencing. constructs both wild-type mutant were transfected into HEK-293 T cells. Three-dimensional modeling, luciferase-reporter test, western blotting cellular...
Purpose: People with hyperuricemia (HUA) are often related to metabolic disorders such as diabetes, syndrome (MetS), and obesity.However, the correlation between excretion of uric acid these diseases is unclear.Our study aimed explore relationship type 2 diabetes (T2D).Methods: A total 228 HUA patients from Tianjin Medical University General Hospital 2022 2023 were included in this study.We collected demographic, biochemical, anthropometric data on each subject.Urine (UUAE) was calculated...