A5100426159- Liver Disease Diagnosis and Treatment
- Lipid metabolism and disorders
- Ferroptosis and cancer prognosis
- Acute Myocardial Infarction Research
- Neonatal Respiratory Health Research
- Medical Research and Treatments
- RNA modifications and cancer
- Lung Cancer Treatments and Mutations
- Coronary Artery Anomalies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lung Cancer Research Studies
- Brain Metastases and Treatment
- Coronary Interventions and Diagnostics
- Respiratory Support and Mechanisms
- Cancer Risks and Factors
- Cancer Mechanisms and Therapy
- Hepatocellular Carcinoma Treatment and Prognosis
- Diet, Metabolism, and Disease
- Neuroscience of respiration and sleep
- Pancreatitis Pathology and Treatment
- Healthcare and Venom Research
- Lung Cancer Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Dialysis and Renal Disease Management
- Cancer Cells and Metastasis
Capital Medical University
2000-2024
Shanghai University of Traditional Chinese Medicine
2009-2024
China Resources (China)
2024
Jinan University
2024
First Affiliated Hospital of Jinan University
2024
First Affiliated Hospital of Xiamen University
2013-2023
Qingdao Municipal Hospital
2020-2023
Qingdao University
2019-2023
Chinese Academy of Sciences
2023
Institute of Biophysics
2023
The present study aimed to identify the recurrence‑associated genes in colon cancer, which may provide theoretical evidence for development of novel methods prevent tumor recurrence. Colon cancer and matched normal samples microarray data (E‑GEOD‑39582) were downloaded from ArrayExpress. Genes with significant variation identified, followed by screening differentially expressed (DEGs). Subsequently, co‑expression network DEGs was constructed using weighted correlation analysis (WGCNA)...
This study aimed to evaluate the clinical performance of low serum calcium and phosphorus in discriminative diagnosis severity patients with coronavirus disease 2019 (COVID-19). We conducted a single-center hospital-based consecutively recruited 122 suspected 104 confirmed COVID-19 during January 24 April 25, 2020. Clinical risk factors were identified. The power regarding was evaluated. Low are more prevalent severe or critical than moderate (odds ratio [OR], 15.07; 95% confidence interval...
Abstract Background Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and irreversible lung disease characterized by dysfunction, ultimately leading to respiratory failure. Many preclinical studies have investigated the therapeutic potential of stem cell-derived exosomes in this disease, particularly mesenchymal exosomes. However, effects embryonic IPF remain unclear. Methods We established bleomycin (BLM)-induced mice model administered human cell (hESC-exo) from first day...
Background Biomarkers in breast neoplasms provide invaluable information regarding prognosis and help determining the optimal treatment. We have examined possible correlation between cancer stem cell (CSC)-like markers (CD133, paired box gene 2 protein (PAX2), epithelial specific antigen (ESA)), a new membrane estrogen receptor (G-protein coupled 30 (GPR30)) invasive ductal carcinomas with known clinicopathological parameters, tumor recurrence, expression of some biomarkers. Methods In 74...
Objective Although many studies have documented the tumor-promoting role of hepsin in several types malignancies, little is known about its clinical and biological significance breast cancer. Materials Methods Hepsin expression was examined 4 pairs fresh tumor samples corresponding nontumor tissues by Western blotting. Immunohistochemistry for performed on an additional cohort 215 archival cancer samples. The analyzed. Knockdown 2 cell lines, MDA-MB-231 HER18, with a high abundance...
Purpose To investigate the dietary nutrient intake of Maintenance hemodialysis (MHD) patients, identify influencing factors, and explore correlation between nutritional disease control indicators.
Fascin, an actin‐cross‐linking protein, is up‐regulated in breast cancer and correlates with a more aggressive disease. This study was conducted to elucidate the effects of manipulating fascin cells on metastasis‐associated events, including proliferation, adhesion, invasion, epithelial–mesenchymal transition (EMT) enrichment CD44 + /CD24 − subpopulation that show some stem/progenitor cell properties. Western blot analysis panel lines revealed high expression MDA‐MB‐435 MDA‐MB‐231 but no or...
Dysregulation of C‑Type Lectin Domain Family 3 Member B (CLEC3B) in serum or tumor tissues has been reported patients with various cancer types. However, the expression and function CLEC3B clear cell renal carcinoma (ccRCC) remain unknown. To examine ccRCC, The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases were examined to determine at transcriptional level it was demonstrated that mRNA significantly downregulated ccRCC compared normal (P<0.0001 P=0.0392 TCGA GEO...
The aim of this study is to examine the safety and efficacy Cinobufacini injection in transarterial chemoembolization (TACE) for treatment huge hepatocellular carcinoma (HCC). Clinical data 56 consecutive patients with HCC larger than 10 cm who had been treated TACE between December 2010 August 2014 were retrospectively analyzed. Among these patients, 31 belonged group 25 epirubicin group. clinical efficacy, survival time, adverse events two groups compared. objective response rate was...
Abstract Background CHD is reported to be the primary cause of death in patients with NAFLD. Genetic susceptibility genes contribute developmental risk NAFLD or CHD. Whether genetic factors could affect not clear. The aim this study was investigate association PNPLA3 I148M and TM6SF2 E167K variants Chinese Han population. Patients methods were genotyped a cohort 189 CHD, as well 242 healthy controls by gene sequencing. Additionally, serum lipids profiles determined standard clinical...
Abstract Non‐small cell lung cancer (NSCLC) is a malignant tumor with low overall cure and survival rates. Uncovering abnormally expressed genes significantly important for developing novel targeted therapies in NSCLC. This study aimed to discover new differentially (DEGs) of The DEGs NSCLC were identified eight data sets from Gene Expression Omnibus (GEO) database. expression profiles the prognostic significance SCN4B LUAD LUSC analyzed using GEPIA LinkedOmics was used identify co‐expressed...
Acute exacerbations show a significant impact on disease morbidity and mortality in chronic obstructive pulmonary (COPD). In contrast to stable COPD, the association of smoking status with clinical laboratory characteristics patients acute COPD (AECOPD) has not been well studied. this retrospective study, we compared never smokers ever their demographic, clinical, Chinese cohort AECOPD. comprising 1,034 consecutive AECOPD, were older (75 vs 70.5 years, padjusted < 0.001) had higher body mass...
Chronic obstructive pulmonary disease (COPD) coexisting with lung cancer is associated severe mortality and a worse prognosis. Inflammation plays an important role in common pathogenic pathways progression. However, few studies have identified the clinical value of neutrophil-to-lymphocyte ratio (NLR) platelet-to-lymphocyte (PLR) COPD cancer, which are systemic inflammatory response markers blood. This study aimed to determine association NLR or PLR characteristics whether can be diagnostic...
Brain metastasis is an unsolved clinical problem in breast cancer patients due to its poor prognosis and high fatality rate. Although accumulating evidence has shown that some pan-histone deacetylase (HDAC) inhibitors can relieve brain metastasis, the specific HDAC protein involved this process unclear. Thus, identifying a closely correlated with will not only improve our understanding of functions family but also help develop novel target for precision therapy.Immunohistochemical staining...
Background Brain metastases (BM) are a common consequence of lung cancer and surgery is effective; however, the factors affecting survival after unclear. The aim this study was to identify outcomes prognoses post‐metastasectomy patients with BM from non‐small cell (NSCLC) at single institution over 15‐year period. Methods NSCLC who had undergone were retrospectively identified. Survival analyzed using Kaplan–Meier curve, univariate multivariate associated identified Cox proportional hazards...
α-fetoprotein (AFP)-producing gastric carcinoma is a rare type of cancer, and the characteristics have not yet been fully elucidated. The present study reports case patient with this cancer. A 66-year-old male was referred to Department Gastrointestinal Surgery, Qianfoshan Hospital, Shandong University (Jinan, China) 20-day history retrosternal pain. computed tomography (CT) scan revealed thickening wall cardia massive lymph node swelling in region lesser curvature stomach. laboratory...
Introduction Trilaciclib is a transient cyclin-dependent kinase 4/6 inhibitor that decreases the incidence of chemotherapy-induced myelosuppression in extensive-stage small cell lung cancer (ES-SCLC). TRACES study was designed to assess safety, efficacy and pharmacokinetics (PK) trilaciclib before chemotherapy Chinese patients with ES-SCLC. Methods The included an open-label safety run-in part (Part 1) double-blinded, placebo-controlled 2) where received or placebo chemotherapy....
Obesity has been recognized as a significant risk factor for postmenopausal breast cancer. The aim of this study is to investigate the prognostic significance body mass index (BMI) in hormone receptor-positive, operable cancer.In retrospective cohort study, 1,192 consecutive patients with curative resection primary cancer were enrolled. Patients assigned two groups according BMI: normal or underweight (BMI < 23.0 kg/m²) and overweight obese ≥ kg/m²). Associations among BMI...
Hypertrophic cardiomyopathy is a heterogeneous myocardial disorder with broad spectrum of clinical presentation and morphologic features. Previous reports indicated that protein kinase C pathway as major determinant cardiac hypertrophy heart failure. Population-based analyses the association between PRKCH gene (encoded PKCη) HCM has not been performed yet. The purpose this study to investigate nonsynonymous SNP (1425G/A) in hypertrophic Chinese population. 323 patients 326 controls were...
PNPLA3 I148M variant and TM6SF2 E167K are recognized as the major genetic modifiers of nonalcoholic fatty liver disease (NAFLD). The present study sought to evaluate potential additive effect two variants on risk NAFLD in Qingdao Han Population, China. We genotyped a cohort 512 unrelated patients 451 healthy controls by sequencing polymerase chain reaction analysis. In addition, serum lipid profiles enzymes were determined standard clinical laboratory methods. minor allele frequencies 45.48%...