A5087388592- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Cancer therapeutics and mechanisms
- RNA modifications and cancer
- Renal and related cancers
- Engineering Education and Curriculum Development
- Educational Reforms and Innovations
- Hedgehog Signaling Pathway Studies
- Cancer Mechanisms and Therapy
- Cancer Cells and Metastasis
- Angiogenesis and VEGF in Cancer
- Genetic Syndromes and Imprinting
- MicroRNA in disease regulation
- Natural Compounds in Disease Treatment
- Reproductive System and Pregnancy
- Melanoma and MAPK Pathways
- Cytokine Signaling Pathways and Interactions
- Nonmelanoma Skin Cancer Studies
- Virus-based gene therapy research
- Biomarkers in Disease Mechanisms
- Metabolomics and Mass Spectrometry Studies
- Cancer and Skin Lesions
- Pharmacogenetics and Drug Metabolism
China Medical University
2012-2025
First Hospital of China Medical University
2004-2021
Jiangsu University of Science and Technology
2021
LOXL1-AS1, a recently characterized long non-coding RNA (lncRNA), has been reported to modulate tumor progression in several types of cancer. However, the expression and role LOXL1-AS1 breast cancer remain unclear. In this study, we sought identify novel lncRNA regulators engaged metastasis. To end, examined 42 cancer-related lncRNAs between MCF7 (with low metastatic potential) MDA-MB-231 high cells. These have found affect invasiveness types, but they are still undefined Among candidates,...
Fascin, an actin‐cross‐linking protein, is up‐regulated in breast cancer and correlates with a more aggressive disease. This study was conducted to elucidate the effects of manipulating fascin cells on metastasis‐associated events, including proliferation, adhesion, invasion, epithelial–mesenchymal transition (EMT) enrichment CD44 + /CD24 − subpopulation that show some stem/progenitor cell properties. Western blot analysis panel lines revealed high expression MDA‐MB‐435 MDA‐MB‐231 but no or...
Abstract Background Our previous studies have shown that the E3 ubiquitin ligase of HMG-CoA reductase degradation 1 (HRD1) functions as a tumor suppressor, overexpression HRD1 suppressed breast cancer proliferation and invasion. However, its role in cell glucose metabolism was unclear. Here, our aim to uncover molecular mechanisms regulating aerobic glycolysis cancer. Methods The effect on robic cells were assessed. Then proliferation, colony formation ability, invasion migration evaluated....
Inadequate trophoblast invasion and increased apoptosis cause serious pregnancy complications. Pleckstrin homology-like domain, family Α, member 2 (PHLDA2) has been linked to fetal size at birth growth restriction in a number of studies. However, the impact PHLDA2 on function had not studied previously, best our knowledge. In present study, immunofluorescence staining demonstrated that primary trophoblasts isolated from placental villous tissues were positive for cytokeratin 18 (CK18),...
Preeclampsia (PE) is one of the most common hypertensive disorders and a leading cause morbidity mortality for pregnant women perinatal babies. Additionally, pleckstrin homology-like domain family A member 2 (PHLDA2) associated with placental dysfunction. However, effect PHLDA2 on trophoblast cell proliferation, migration invasion has not been investigated. In this study, 15 PE patients normal were recruited clinical characteristics summarized. Pleckstrin levels in tissues examined using...
To investigate the correlation between mitogen-activated protein kinase (MAPK) signal transduction pathway and multidrug resistance (MDR) in MGC803 cells.Western blot was used to analyze expression of MDR associated gene transient vincristine (VCR) induced cells, which were treated with or without specific inhibitor MAPK, PD098059. Morphologic analysis cells by VCR PD098059 determined Wright-Giemsa staining. The cell cycle performed using flow cytometric assay drug sensitivity exposed tested...
General Secretary Xi stressed that the fundamental task of colleges and universities is personnel training, The Ministry education pointed out higher should adhere to principle "Based on Undergraduate Education" promote "Four Regressions".As basic work talent cultivation in Colleges universities, quality effectiveness teaching determines level undergraduate cultivation.Maintaining central position work, strengthening teachers' sense responsibility quality, using performance evaluation...
The androgen receptor (AR) is uncommon among Nuclear (NR) because of its intramolecular interaction(termed the N/C interaction) and thus coactivators can alternatively bind to surfaces in AR amino terminal. Mediator complex plays a key coregulatory role steroid hormone dependent transcription chiefly targeted NRs via LxxLL‐containing MED1 subunit. However, mechanisms by which recruits have remained unclear. Here we show that binds distinct amino‐terminal region termed transactivation unit‐1...
This study aims to identify the expression of lipoma preferred partner (LPP) in Paget disease (PD) and further understand pathogenesis PD.Tissue microarray was used evaluate LPP by immunohistochemistry 40 PD patients. The results were combined with clinical histopathological characteristics. Patient files analyzed retrospectively.Twenty-one cases mammary (MPD) 19 extramammary (EMPD) involving vulva, scrotum, penis. expressed this significantly greater MPD versus EMPD (P = .031). related age...
Objective To investigate the role of hypoxia inducible factor(HIF)-prolyl hydroxylase 1 (HPHl)and factor inhibiting HIF-1(FIH-1)in placentas in pathogenesis and development severe pre-eclampsia.Methods RT-PCR western blot analyses were used to detect HPH1 FIH-1expression levels 34 patients with pre-eclampsia 24 cases term pregnancy (normal group)and their correlations symptoms analyzed.Results (1)The HPHI mRNA protein expression group 0.40±0.04 59.5±3.4 separately,significantly lower than...
P21-activated kinase 5 (PAK5) plays an important role in tumors. Yet, the potential functional of PAK5 during mammary tumorigenesis vivo is unknown. Here, we showed that deficiency repressed MMTV-PyVT-driven breast tumorigenesis. DEAD-box RNA helicase (DDX5) was a new substrate PAK5, which phosphorylated on threonine 69. PAK5-mediated DDX5 phosphorylation promoted cancer cell proliferation and metastasis vitro vivo. The increased expression levels were associated with poor outcomes patients....