A5046992890- Microfluidic and Capillary Electrophoresis Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Microfluidic and Bio-sensing Technologies
- Anesthesia and Sedative Agents
- Intensive Care Unit Cognitive Disorders
- Multiple Myeloma Research and Treatments
- Plant Molecular Biology Research
- Biosensors and Analytical Detection
- Mass Spectrometry Techniques and Applications
- Chronic Myeloid Leukemia Treatments
- Multicomponent Synthesis of Heterocycles
- Plant Reproductive Biology
- Analytical Chemistry and Chromatography
- Oxidative Organic Chemistry Reactions
- Peptidase Inhibition and Analysis
- Electric Vehicles and Infrastructure
- Orthopedic Infections and Treatments
- Smart Grid Energy Management
- Advanced biosensing and bioanalysis techniques
- Heparin-Induced Thrombocytopenia and Thrombosis
- Venous Thromboembolism Diagnosis and Management
- Intramuscular injections and effects
- Cardiac, Anesthesia and Surgical Outcomes
- AI and Big Data Applications
- Adenosine and Purinergic Signaling
Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine
2025
Third Affiliated Hospital of Sun Yat-sen University
2016-2024
Sun Yat-sen University
2016-2024
Institute of Botany
2024
Nanjing University of Chinese Medicine
2024
Chinese Academy of Sciences
2024
Shanghai Electric (China)
2024
China University of Mining and Technology - Beijing
2023
China University of Mining and Technology
2023
Southern Medical University
2020-2022
Non-invasive assessment of pulmonary nodule malignancy remains a critical challenge in lung cancer diagnosis. Traditional methods often lack precision differentiating benign from malignant nodules, particularly the early stages. This study introduces an approach using multifractal spectrum analysis to quantitatively evaluate characteristics. A fractal-based protocol was developed process computed tomography (CT)-digital imaging and communications medicine (DICOM) data, enabling...
Postoperative delirium is a common complication following major surgeries, leading to variety of adverse effects. However, there paucity literatures studying the incidence and risk factors associated with after primary elective total hip arthroplasty (THA) using large-scale national database.A retrospective database analysis was performed based on Nationwide Inpatient Sample (NIS) from 2009 2014. Patients who underwent THA were included. Patient demographics, preoperative comorbidities,...
Autologous bone grafts are the gold standard for treating defects. However, limited supply and morbidity at donor site restrict its extensive use. Therefore, developing graft materials as an alternative to autologous has gained considerable attention. Injectable hydrogels endowed with osteogenic potential have ability fill irregular defects using minimally invasive procedures thus been attracting researchers' from a clinical perspective, most fabrication methods employed current injectable...
In this manuscript, we discuss the use of photoactivated polycarbonate (PC) for purification dye-labeled terminator sequencing fragments using solid-phase reversible immobilization (SPRI) prior to gel electrophoretic sorting these DNAs. An bed DNA was produced by exposing a posted microchannel UV radiation, which induced surface photooxidation reaction, resulting in production carboxylate groups. The contained microposts increase loading level DNAs improve signal intensity without need...
Acute myeloid leukemia (AML) is a malignant hematological disease, originating from hematopoiesis stem cell differentiation obstruction and clonal proliferation. New reagents or biologicals for the treatment of AML are urgently needed, exosomes have been identified as candidate biomarkers disease diagnosis prognosis. This study aimed to investigate effects bone marrow mesenchymal cells (BMSCs) on well underlying microRNA (miRNA)-mediated mechanisms.Exosomes were isolated using precipitation...
We report a method to elucidate the structure of triacyl-glycerols (TAGs) containing monoene or diene fatty acyl groups by atmospheric pressure covalent adduct chemical ionization (APCACI) tandem mass spectrometry using acetonitrile as an formation reagent. TAGs were synthesized with structures ABB and BAB, where A is palmitate (C16:0) B isomeric C18 unsaturated at position 9, 11, 13 positions 9 10 12, 12. In addition species m/z 54 observed in previous CI studies acid methyl esters, we also...
We report on the fabrication and performance of a gel microfluidic chip interfaced to laser desorption/ionization (LDI) mass spectrometry with time-of-flight analyzer. The was fabricated from poly(methylmethacrylate) poly(dimethyl siloxane) cover. Sodium dodecyl sulfate-polyacrylamide electrophoresis performed in channel chip. After electrophoresis, cover removed either PDMS or PMMA mounted modified MALDI ion source for analysis. Ions were formed by irradiating 2.95 microm radiation pulsed...
The development of targeted tyrosine kinase inhibitors (TKIs) has succeeded in altering the course chronic myeloid leukemia (CML). However, a number patients have failed to respond or experienced disease relapse following TKI treatment. Proviral integration site for moloney murine virus‑1 (PIM‑1) is serine/threonine that participates regulating apoptosis, cell cycle, signal transduction and transcriptional pathways, which are associated with tumor progression, poor prognosis. SMI‑4a...
Multiple myeloma (MM) is the second most common haematological malignancy. Despite development of new drugs and treatments in recent years, therapeutic outcomes patients are not satisfactory. It necessary to further investigate molecular mechanism underlying MM progression. Herein, we found that high E2F2 expression was correlated with poor overall survival advanced clinical stages patients. Gain- loss-of-function studies showed inhibited cell adhesion consequently activated...
A miniaturized, solid-phase nanoreactor was developed to prepare Sanger DNA-sequencing ladders which directly interfaced a capillary gel electrophoresis system. biotinylated fragment of the rat brain actin gene (1 kbp) amplified by PCR and attached interior wall an (aminoalkyl)silane-derivatized fused-silica tube via biotin/streptavidin/biotin linkage. Coverage with DNA averaged 77 ± 10%. Stability anchored template under pressure (33 nL/s) electroosmotic flows (11.3 were favorable,...
The direct combination of gel electrophoresis and infrared laser desorption/ionization time-of-flight mass spectrometry has been demonstrated. We present results for desorption ionization peptides proteins directly from a polyacrylamide without the addition matrix. Analyte molecules up to 6 kDa were ionized vacuum-dried sodium dodecyl sulfate−polyacrylamide after electrophoretic separation. Mass spectra obtained at wavelength 2.94 μm, which is consistent with IR absorption by N−H O−H stretch...
RAD52 (Radiation sensitive 52) is a key factor in DNA damage repair (DDR) bypass, which participates single‑strand annealing (SSA) after end excision, while breast cancer type 1 susceptibility protein (BRCA1)/breast 2 (BRCA2) play critical roles homologous recombination (HR) repair. The present study aimed to determine whether RAD52‑induced regulation of bypass occurs acute myeloid leukemia (AML) cells and explore the underlying mechanism. Herein, we applied an aptamer AML with downregulated...
Backgrounds: Heparin-induced thrombocytopenia (HIT) is a severe immune-mediated complication of heparin exposure, leading to negative consequences after total hip (THA) and knee arthroplasty (TKA). Materials Methods: A retrospective study was conducted using the National Inpatient Sample (NIS) database from 2005 2014. The incidence outcomes HIT THA or TKA were documented. Logistic regression analysis performed identify postoperative risk factors. Results: 59 3045 patients who underwent 1228...
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The electricity consumption of the textile industry accounts for 2.12% total in society, making it one high-energy-consuming industries China. requires use a large amount industrial steam at various temperatures during production processes, its dispatch and operation more complex compared to conventional electricity–heat integrated energy systems. As an important demand-side management platform connecting grid with distributed resources, virtual power plant can aggregate users through...
Abstract Mitochondrial quality regulation plays an important role in affecting the treatment sensitivity of multiple myeloma (MM). We aimed to develop a mitochondrial genes (MQRGs)‐related prognostic model for MM patients. The Genomic Data Commons‐MM bulk RNA‐seq, mutation, and single‐cell RNA‐seq (scRNA‐seq) dataset were downloaded, MQRGs gene set was collected previous study. “maftools” CIBERSORT used mutation immune‐infiltration analysis. Subsequently, “ConsensusClusterPlus” perform...