A5101702813- MicroRNA in disease regulation
- Diabetic Foot Ulcer Assessment and Management
- Orthopedic Infections and Treatments
- Rheumatoid Arthritis Research and Therapies
- Wound Healing and Treatments
- RNA Interference and Gene Delivery
- Total Knee Arthroplasty Outcomes
- Autoimmune and Inflammatory Disorders Research
- Cardiac, Anesthesia and Surgical Outcomes
- Spondyloarthritis Studies and Treatments
- Circular RNAs in diseases
- Bone Tissue Engineering Materials
- Cancer Mechanisms and Therapy
- Bone fractures and treatments
- Bacterial biofilms and quorum sensing
- Frailty in Older Adults
- Biopolymer Synthesis and Applications
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Neurofibromatosis and Schwannoma Cases
- Extracellular vesicles in disease
- Angiogenesis and VEGF in Cancer
- Natural product bioactivities and synthesis
- Anesthesia and Sedative Agents
- Telemedicine and Telehealth Implementation
- Macrophage Migration Inhibitory Factor
Southern Medical University
2011-2024
Nanfang Hospital
2011-2024
Bone implant outcome and bone regeneration properties can be improved by the immunomodulation of exosomes (Exos) derived from marrow mesenchymal stem cells (BMSCs), which contain cytokines, signaling lipids, regulatory miRNAs. Analysis miRNAs in BMSCs-derived showed that miR-21a-5p exhibited highest expression was associated with NF-κB pathway. Hence, we developed an functionality to promote incorporation immunoregulation. Mediated potent interaction between tannic acid (TA)...
The proficient handling of diabetic wounds, a rising issue coinciding with the global escalation diabetes cases, poses significant clinical difficulties. A range biofunctional dressings have been engineered and produced to expedite healing process wounds. This study proposes multifunctional hydrogel dressing for wound healing, which is composed Polyvinyl Alcohol (PVA) N1-(4-boronobenzyl)-N3-(4-boronophenyl)-N1, N1, N3, N3-teramethylpropane-1, 3-diaminium (TSPBA), dual-drug loaded Gelatin...
[This retracts the article DOI: 10.2147/IJN.S270681.].
Evidence of efficacy a traditional herbal formula Xianlinggubao (XLGB) for treatment osteoarthritis (OA) is limited. The present study was designed to evaluate the XLGB in management patients with knee and hand OA. This multicenter, stratified, open‐label, randomized controlled trial conducted at six centers China. People aged 40 or above, diagnosed OA hand, were randomly assigned group watchful waiting control group. Main outcome measures changes numeric pain rating scales (NPRS) Western...
The aim of the current study was to explore effects dexamethasone (DXM) on autophagy and senescence in chondrocytes. Collagen II aggrecan were examined normal chondrocytes isolated from Sprague‑Dawley rats. Following stimulation with DXM, LysoTracker Red staining, monodansylcadaverine (MDC) green fluorescent protein‑red protein‑light chain 3 (LC3) western blotting used detect levels Mechanistic target rapamycin (mTOR) pathway‑associated molecules investigated by blotting. Cell analyzed...
Circular RNAs (circRNAs) have emerged as important roles in various inflammatory processes of rheumatic diseases. However, their expression profiles and influences the pathogenesis ankylosing spondylitis (AS) remain unclear. In this study, we revealed differential circRNAs peripheral blood mononuclear cells (PBMCs) AS by circRNA sequencing. We screened differentially expressed verified that hsa_circ_0000652 was upregulated had potential to be a biomarker progression. Functionally, promoted...
Macrophages activation is crucial in pathogenesis of rheumatic diseases like ankylosing spondylitis (AS). Circular RNAs (circRNAs)-induced macrophage-associated inflammation participates many autoimmune but remains elusive AS. Here, we verified increased expression circIFNGR2 peripheral blood mononuclear cells from patients with AS and its levels were correlated the severity. In vitro assays revealed that enhances macrophage proliferation, regulates M1/M2 polarization NF-κB/Akt pathways. We...
A retrospective study was performed in patients with ankylosing spondylitis (AS) from south China, to investigate the efficacy and safety of infliximab after total hip arthroplasty (THA). Thirty-two AS were divided into two groups. The treatmen group recieved at four weeks unilateral THA (11 patients) compare a control (21 patients). Patients treated traditional medications. Clinical assessment, laboratory examinations, x-rays pre- postoperatively. BASDAI score decreased more six 12 months...
Neurothekeomas are unusual benign soft tissue tumors of the peripheral nervous system, which commonly occur on head, neck and upper extremities young females in second third decades life. This is first case report neurothekeoma developing simultaneously thoracic lumbar area a 51-year-old male. The two were completely excised along capsule under local anaesthesia incisions closed layers following adequate hemostasis. Histopathologically, examination microscopic slides from masses revealed...
Patients with frailty get more and attention in clinical practice. Yet, no large-scale studies have explored the impact of on perioperative acute medical surgical complications following TJA. what is more, comorbid diseases may lead, at least additively, to development frailty. There also find possible interaction between comorbidity postoperative after TJA.Discharge data 2,029,843 patients who underwent TJA from 2005 2014 National Inpatient Sample (NIS) database, which was analyzed using...
Objective To observe the inhibitory effect of tumstatin related peptide T3 mediated by short to osteosarcoma vascular. Methods Through MTS assay, wound healing targeting-T3 and on human umbilical veil endothelial cell was studied in vitro. After preparation 50 nude mice model bearing osteosarcoma, too large or small tumors were eliminated left ones divided into 4 groups (6 animals for each group: peptide, CTX, PBS) randomly. weight tumor, histopathologicol slice immunohistochemical methods....
Abstract Background The occurrence of hospital-acquired pressure ulcers (HAPUs) is disturbing and costly, leading to a variety adverse effects. objective this study was examine the incidence risk factors HAPUs following total hip arthroplasty (THA) using large-scale national database. Methods A retrospective database analysis performed based on Nationwide Inpatient Sample (NIS) from 2005-2014. Patients who underwent THA were included. Patient demographics, hospital characteristics, length...