A5103047930- Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Immune Cell Function and Interaction
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Immune cells in cancer
- Cancer-related molecular mechanisms research
- Glioma Diagnosis and Treatment
- Colorectal Cancer Treatments and Studies
- Acute Myeloid Leukemia Research
- Chronic Lymphocytic Leukemia Research
- Chemokine receptors and signaling
- Syphilis Diagnosis and Treatment
- Brain Metastases and Treatment
- Mosquito-borne diseases and control
- Multiple Myeloma Research and Treatments
- Chromatography in Natural Products
- Tryptophan and brain disorders
- Family Support in Illness
- Pediatric Hepatobiliary Diseases and Treatments
- Medicinal Plant Pharmacodynamics Research
- Radiopharmaceutical Chemistry and Applications
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Immunotherapy and Immune Responses
- Parvovirus B19 Infection Studies
Sun Yat-sen University
2007-2024
Sun Yat-sen University Cancer Center
2014-2024
State Key Laboratory of Oncology in South China
2013-2023
University of Nebraska Medical Center
2018
Key Laboratory of Guangdong Province
2013
Epstein-Barr virus (EBV) infection has been observed in tumor-infiltrated macrophages, but its effects on macrophage immune functions are poorly understood. Here, we showed that some macrophages the tumor stroma of nasopharyngeal carcinoma (NPC) tissue expressed immunosuppressive protein indoleamine 2,3-dioxygenase (IDO) more strongly than did cells. EBV induced mRNA, protein, and enzymatic activity IDO human monocyte-derived (MDMs). Infection increased production necrosis factor alpha...
Abstract Purpose: Prediction models for acute myeloid leukemia (AML) are useful, but have considerable inaccuracy and imprecision. No current model includes covariates related to immune cells in the AML microenvironment. Here, an risk score was explored predict survival of patients with AML. Experimental Design: We evaluated predictive accuracy several silico algorithms composition based on a reference multi-parameter flow cytometry. CIBERSORTx chosen enumerate from public datasets develop...
Studies have found that lymphoma patients often exhibit abnormal lipid metabolism, and a decrease in serum high-density lipoprotein cholesterol (HDL-C) may occur during lymphomagenesis tumor growth. However, no literatures investigated the role of HDL-C with extranodal natural killer/T cell (ENKTL). In this study, we retrospectively reviewed level 107 newly diagnosed ENKTL received either l-asparaginase-based regimen or EPOCH as induction chemotherapy, evaluated its prognostic value. The...
γδT cells are non-conventional T and serve as the bridge for connecting innate adaptive immune systems. form a substantial population at barrier sites play an important role in development of physiology, inflammation, autoimmune diseases tumors. not only distribute maternal-fetal interface during pregnancy but also non-pregnant uterus. However, phenotypes functions uterus were clear. In current study, we found that percentages significantly higher than peripheral blood most distributed...
The widespread reverse syphilis screening algorithm involves 1 more treponemal test than the traditional algorithm, resulting in increased medical costs. In first step of a chemiluminescence microparticle immunoassay is used to detect Treponema pallidum (TP) antibody on basis signal-to-cutoff (S/CO) ratios. We hypothesized that by analyzing S/CO ratios, we could determine strategy reduce unnecessary confirmatory testing.The ARCHITECT Syphilis TP assay using was as test, and all reactive...
To investigate the predictive value of chemokine CCL27 for identifying early stage nasopharyngeal carcinoma (NPC) patients within a population seropositive Epstein-Barr virus (EBV) capsid antigen-specific IgA (VCA-IgA). in plasma samples from 104 NPC patients, 112 VCA-IgA–positive healthy donors, and 140 VCA-IgA–negative normal subjects was measured by ELISA. Expression tissue 20 donors examined immunohistochemical staining. Levels (607.33 ± 218.81 pg/ml) were significantly higher than...
We developed a simple and effective rinsing technique (RT) of needle biopsies to produce cell suspensions for flow cytometry (FCM) evaluated whether the RT is comparable conventional tissue suspension (TCS) technique.We retrieved 93 core biopsy cases employing FCM 25 using TCS FCM.The diagnostic concordance between results morphologic diagnoses both groups was compared. The in group (92.6%) (71.4%). Furthermore, associated with number isolated cells. accuracy increased significantly when...
Previous studies had explored the diagnostic or prognostic value of NRP-1/CD304 in blastic plasmacytoid dendritic cell neoplasm (BPDCN), acute myeloid leukemia (AML), and B-cell lymphoblastic (B-ALL), whereas expression application other common hematological diseases have not been reported. Bone marrow samples from 297 newly diagnosed patients with various were collected to detect by flow cytometry (FCM). The efficacy NRP-1/ CD304-positive was analyzed receiver operating characteristic (ROC)...
The investigation of enhancer zeste homolog 1 (Ezh1) in the context dengue infection immunity has been limited, necessitating further exploration to elucidate its precise role and underlying mechanisms during infections. To address this gap, we generated Ezh1 knockout mice obtained bone marrow spleen samples from both wild‐type (WT) counterparts. Leveraging RNA sequencing (RNA‐seq) analysis, identified enrichment genes associated with interleukin‐17 (IL‐17) signaling pathway among...
Abstract Background Conventional protocols utilize core needle biopsy (CNB) or fine aspiration (FNA) to produce cell suspension for flow cytometry (FCM) is a diagnostic challenge lymphoid malignancies. We aim develop an alternative CNB rinsing technique (RT) FCM during this mini‐invasive procedure of lymphoma diagnosis. Methods FNA and specimens from the same lesion 93 patients with suspected were collected under guidance B‐ultrasound simultaneously. The fresh samples prepared by RT...
Introduction Immune checkpoint blockade inhibitor (ICI) therapy offers significant survival benefits for malignant melanoma. However, some patients were observed to be in disease progression after the first few treatment cycles. As such, it is urgent find convenient and accessible indicators that assess whether can benefit from ICI therapy. Methods In training cohort, flow cytometry was used determine absolute values of 66 immune cell subsets peripheral blood melanoma (n=29) before with...
Abstract Introduction: It is common to evaluate lymphocytes subsets in virus infection, immunodeficiency diseases and cancer. This study retrospectively analyzed serum lymphocyte survival outcomes intracranial germ cell tumors (iGCTs) patients. Methods Serum from145 iGCTs patients were collected by flow cytometry. Clinical information was extracted from the database Sun Yat-sen University Cancer Center confirmed through outpatient visits telephone follow-up. Results 76 germinoma, 29 mixed...
Introduction Immune status was evaluated by means of lymphocyte subset counts and immune factors in cancer. This study analyzed the peripheral blood index survival outcomes intracranial germ cell tumor (iGCT) patients. Methods Peripheral levels interleukin (IL)-2, IL-4, IL-6, IL-10, necrosis factor (TNF), interferon-γ (IFN) from 133 iGCT patients were collected retrospectively analyzed. Their clinical information extracted hospital database, prognosis confirmed telephone visit. Patients...
Abstract BACKGROUND: Previous studies had explored the diagnostic or prognostic value of NRP-1/CD304 in blastic plasmacytoid dendritic cell neoplasm (BPDCN), acute myeloid leukemia (AML) and B-cell lymphoblastic (B-ALL), whereas expression application other common hematological diseases have not been reported. METHODS: Bone marrow samples from 297 newly diagnosed patients with various were collected to detect by flow cytometry (FCM). The efficacy NRP-1/ CD304-positive was analyzed receiver...
Accurate assessment of the nature enlarged retropharyngeal lymph nodes (RLN) nasopharyngeal carcinoma (NPC) patients after radiotherapy is related to selecting appropriate treatments and avoiding unnecessary therapy. This study aimed develop a non-invasive effective model for predicting recurrence RLN (RRLN) in NPC. The data post-radiotherapy NPC (N = 76) with abnormal enlargement who underwent endonasopharyngeal ultrasound-guided fine-needle aspirations (EPUS-FNA) were examined. They...