A5068268460- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Reproductive System and Pregnancy
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- IL-33, ST2, and ILC Pathways
- Helicobacter pylori-related gastroenterology studies
- Plant-derived Lignans Synthesis and Bioactivity
- Intraperitoneal and Appendiceal Malignancies
- Immune Response and Inflammation
- Plant biochemistry and biosynthesis
- Sphingolipid Metabolism and Signaling
- Dermatology and Skin Diseases
- Immunodeficiency and Autoimmune Disorders
Changsha Medical University
2022-2024
Sun Yat-sen University
2021
Purpose Most malignant effusion is secondary to metastases the pleura or peritoneum and portend poor oncological outcomes.Malignant has different tumor microenvironment from primary tumor, containing a variety of cytokines immune cells directly contacting with cells.However, characteristic CD4 + T CD8 in remains unclear.Methods Malignant including peritoneal ascites pleural fluid thirty-five patients were collected compared matched blood.A detailed characterization conducted using flow...
Unlike T cells in other tissues, uterine must balance strong immune defense against pathogens with tolerance to semiallogeneic fetus. Our previous study fully elucidated the characteristics of γδT nonpregnant uterus and mechanism modulated by estrogen. However, comprehensive knowledge immunological properties αβT (including CD4+T CD8+T) nonpregnancy has not been acquired. In this study, we compared between blood using mouse human sample. It showed that most CD8+T murine endometrium were...
γδT cells are non-conventional T and serve as the bridge for connecting innate adaptive immune systems. form a substantial population at barrier sites play an important role in development of physiology, inflammation, autoimmune diseases tumors. not only distribute maternal-fetal interface during pregnancy but also non-pregnant uterus. However, phenotypes functions uterus were clear. In current study, we found that percentages significantly higher than peripheral blood most distributed...
Tissue-resident memory γδT cells at mucosal and epithelial sites play an important role for pathogen clearance, immunosurveillance, participating in physiological processes. Different from other barrier sites, the immune uterus face protection against infections tolerate allogeneic fetus during a successful pregnancy. In previous study, we found that tissue-resident were enriched both human murine highly expressed IL-17 promoted invasion of trophocytes vitro. current but not blood or spleens...
B cells play a key role in humoral immune responses by producing antibodies. Although there are numerous research on memory definition markers and cytokines cell development, different studies have yielded contradictory conclusions due to species studied, the stimulating agents used. In current study, we conducted detailed characterization of human CBMCs, PBMCs tonsil, including expression Igs, activation markers. Furthermore, found that considerable amounts IgA IgG were expressed CD27
Abstract The field of tissue‐resident B cells has received increasing attention, yet the feature tissue in respiratory system is unclear. Here, we first show that non‐circulating obtained from nasal, trachea and lung tissues are numerically phenotypically distinct their circulating counterparts. Analysis single cell transcriptome sequence identified multiple differentially expressed genes between cells, which illustrated heterogeneity. Furthermore, found high expression CXCR3 on chemokine...
Tissue-resident memory T cells (TRM) are different from effector (TEM) and central (TCM) contribute to the protective immunity against local challenges. Currently, we found that CD4+ CD8+ TRM in nasal mucosa, trachea, lungs, lavage fluids were heterogeneous on expression of CD69 CD103 as well production cytokines including IFN-γ, IL-2, TNF-α. After intranasal vaccination mice with BCG, respiratory tissues expressed higher levels chemokine CXCL16 CXCR6 CXCL16. In addition, antigen-specific...
25-hydroxycholesterol (25-HC) and its enzymes influenced the function of immune cells, such as macrophages T played a role in various immune-related diseases. 25-HC has been pointed out to regulate system variety ways, antiviral, pro-tumorigenic, apoptosis-inducing previous years, however, response inflammation is still insufficiently clear. This paper dedicated study inflammatory bowel disease (IBD) mice mechanism with intention further elucidating relationship between metabolism immunity....
Abstract Purpose Most malignant effusion are secondary to metastases the pleura or peritoneum and portend poor oncological outcomes. Malignant have different tumor microenvironment from primary tumor, containing a variety of cytokines immune cells directly contacting with cells. However, characteristic CD4 + T CD8 in remains unclear. Methods including peritoneal ascites pleural fluid thirty-five patients were collected compared matched blood. A detailed characterization conducted using flow...
<p indent="0mm">Most effector T cells are known to die as only a few of them became memory following immune responses. According their distribution, function, and transcription factors, can be divided into cells, central tissue resident (T<sub>RM</sub>). The do not circulate in the blood lymph nodes but found non-lymphoid tissues, which includes skin mucous membranes, urogenital system, brain, respiratory lung, liver tissues. form play defense response directly quickly when pathogens invade...
Spodoptera litura ( S. ) is a polyphagous, explosive, and world-distributed agricultural pest. Because of the resistance, resurgence, residue problems chemical pesticides, new environment-friendly methods are needed to control spreading litura. The present study was conducted investigate effects mechanisms botanical pesticide, Pieris Japonica extracts (PJE), on Methods: PJE prepared by ethyl acetate identified LC-MS/MS. were cultivated in our lab. survival rate, growth development tested...