A5068110727- Lymphoma Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Eosinophilic Disorders and Syndromes
- CNS Lymphoma Diagnosis and Treatment
- Innovations in Medical Education
- Chronic Myeloid Leukemia Treatments
- Blood disorders and treatments
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- AI in cancer detection
- Radiomics and Machine Learning in Medical Imaging
- Hematological disorders and diagnostics
- Acute Myeloid Leukemia Research
- Radiology practices and education
- Oral Health Pathology and Treatment
- Lymphatic System and Diseases
- Diabetes and associated disorders
- Clusterin in disease pathology
- Biomarkers in Disease Mechanisms
- Lung Cancer Diagnosis and Treatment
- Animal and Plant Science Education
- Lymphadenopathy Diagnosis and Analysis
- Viral Infections and Immunology Research
- Genetic and rare skin diseases.
- Liver Diseases and Immunity
University of Maryland, Baltimore
2025
U-M Rogel Cancer Center
2025
Johns Hopkins Medicine
2019-2024
Johns Hopkins University
2018-2024
Johns Hopkins Hospital
2020-2024
National Institutes of Health Clinical Center
2017-2021
Weinberg Medical Physics (United States)
2019
National Institutes of Health
2017-2019
University of Nebraska Medical Center
2012-2018
National Cancer Institute
2017
Introduction. Clusterin (CLU) has been noted to mark synovium adjacent tenosynovial tumors, and studies suggest that podoplanin (PP) is upregulated in inflammatory arthritis. Characterization of synovial staining with CLU PP various nonneoplastic disease states not described. Methods. A microarray was created from paraffin-embedded human synovium, including 19 normal/noninflammatory (10 weight-bearing joints, 8 non-weight-bearing joints), 9 rheumatoid arthritis, 10 cysts, 3 osteoarthritis...
We developed a simple and effective rinsing technique (RT) of needle biopsies to produce cell suspensions for flow cytometry (FCM) evaluated whether the RT is comparable conventional tissue suspension (TCS) technique.We retrieved 93 core biopsy cases employing FCM 25 using TCS FCM.The diagnostic concordance between results morphologic diagnoses both groups was compared. The in group (92.6%) (71.4%). Furthermore, associated with number isolated cells. accuracy increased significantly when...
Langerhans Cell Histiocytosis (LCH) and the non-LCH, Erdheim Chester Disease, are rare histiocytic neoplasms with distinctive clinical immunophenotypic features, but several overlapping molecular features. LCH is a neoplasm of Langerin-positive, CD1a-positive, S100-positive dendritic cells (DCs), once thought to arise from epidermal or mucosal-derived (LC) due morphologic, immunophenotypic, ultrastructural similarities between neoplastic cell physiologic LC [5,6]. However, gene expression...
Pathologists who enter the workforce must have a diverse skill set beyond that of clinical diagnostics alone. Anticipating this need, Johns Hopkins Pathology Residency Program developed Special Expertise Tracks to enhance training in relevant subspecialty domains. Using combination discussions and surveys, we assessed: (1) our current resident curriculum; (2) perceived curricular strengths needs; (3) career preferences ultimate paths; (4) barriers implementing an advanced elective (5)...
Abstract Objectives This study compares the effectiveness of an interactive e-learning module with a traditional text-based method for teaching peripheral blood smear analysis. Methods Pathology trainees at Accreditation Council Graduate Medical Education residency programs were asked to participate. Participants completed multiple-choice test on findings. Trainees randomized into completing or PDF reading exercise same educational content. Respondents rated their experience and...
Microscopic review of tissue sections is foundational importance in pathology, yet the traditional chemistry-based histology laboratory methods are labour intensive, destructive, poorly scalable to evolving needs precision medicine and cause delays patient diagnosis treatment. Recent AI-based techniques offer promise upending workflow; one such method developed by PictorLabs can generate near-instantaneous diagnostic images via a machine learning algorithm. Here, we demonstrate utility...
Abstract Objectives Recent studies have shown that the pathology workforce is at risk of decreased workplace well-being, which may lead to job satisfaction, increased attrition, burnout, depression, anxiety, and suicidality, but there has been relatively little research on well-being initiatives designed for pathologists, trainees, laboratory professionals. Some suggested decrease burnout increase satisfaction engagement. Methods Here we describe creation a Pathology Wellness Committee in...
Chronic myeloid leukemia (CML) is a clonal hematopoietic stem cell disorder characterized by reciprocal translocation, t(9;22) (q34.1;q11.2). This leads to fusion of the BCR and ABL1 genes, encoding an active tyrosine kinase that causes unregulated proliferation lineage. The BCR/ABL1 protein found not only in CML, but also subset de novo B-lymphoblastic (B-LL). However, CML characteristically slightly longer p210 variant, whereas p190 variant more frequently B-LL. Without treatment, will...
Large granular lymphocytosis (LGL)—or LGL leukemia—is a T- or NK-cell lymphoproliferative disorder that often results in cytopenias and autoimmune phenomena. Several studies have described subset of patients after allogeneic blood marrow transplantation (alloBMT), almost exclusively the setting asymptomatic lymphocytosis. Some suggested an association with improved transplant-related outcomes. In contrast, clinically significant alloBMT is only small case reports. This study sought to assess...
High-risk cytogenetics and minimal residual disease (MRD) after chemoimmunotherapy (CIT) predict unfavorable outcome in chronic lymphocytic leukemia (CLL). This phase 2 study investigated risk-adapted CIT treatment-naïve CLL (NCT01145209). Patients with high-risk received induction fludarabine, cyclophosphamide, ofatumumab. Those without fludarabine After induction, MRD positive (MRD+) patients 4 doses of ofatumumab consolidation. negative (MRD-) had no intervention. Of 28 evaluable for...
The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), set of national standards teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology, Diagnostic Medicine Therapeutic Pathology. For additional information, full list objectives all competencies, see http://journals.sagepub.com/doi/10.1177/2374289517715040. 1.
Abstract Background Current clinical practices are shifting towards utilizing less invasive biopsy techniques, including fine needle aspiration (FNA) and core biopsies. If a patient has suspected hematologic malignancy, portion of the FNA sample is typically submitted for flow cytometry (FC) analysis, providing valuable immunophenotypic data. Methods specimens were identified via pathology database search. All cases morphologic evaluated subset analyzed by FC. Results 245 identified; 84%...
7544 Background: LGL - often called leukemia is a clonal disorder of T or NK cells associated with cytopenias, autoimmunity, splenomegaly, and B symptoms. There are limited number studies benign expansion after alloBMT, some suggesting an association improved transplant-related outcomes. In contrast, clinically significant alloBMT only described in case reports. Methods: We cross referenced all patients receiving at Johns Hopkins since 2010 who were evaluated for by peripheral blood (PB)...